African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Full Length Research Paper

Anti-depressive activity of Gardeniae fructus and geniposide in mouse models of depression

Shu-Ling Liu1†, Ying-Chih Lin2†, Tai-Hung Huang3, Shu-Wen Huang4 and Wen-Huang Peng1*
1School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, 91, Hsieh Shih Road, Taichung, Taiwan, Republic of China. 2Department of Optometry, Jen-Teh Junior College of Medicine, Nursing and Management No. 79-9, Sha-Luen-Hu, Xi Zhou Li, Hou-Loung Town, Miaoli County 35664, Taiwan, Republic of China. 3School of Pharmacy, College of Pharmacy, China Medical University, 91, Hsieh Shih Road, Taichung, Taiwan, Republic of China. 4Department of Pharmacy, Chiayi Christian Hospital, 539 Jhongsiao Road Chia-Yi City, Taiwan, Republic of China.
Email: [email protected]

  •  Accepted: 08 September 2011
  •  Published: 08 October 2011

Abstract

We evaluated the anti-depressive activity of ethanolic extracts of Gardenia jasminoides Ellis. (GJ EtOH), Gardenia jasminoides Ellis. var. grandiflora Nakai. (GJG EtOH) and geniposide with mouse forced swimming test (FST) and tail suspension test (TST). In addition, we investigated the possible mechanisms of action of anti-depressive effect of geniposide (GPO). The results showed that GJEtOH (0.1, 1.0 g/kg, p.o.) and GJG EtOH (0.1, 1.0 g/kg, p.o.) significantly reduced the immobility time of mice in both FST and TST, but they did not affect the locomotor activity of mice. Geniposide (10 mg/kg, i.p.) augmented the anti-depressive effect of desipramine (5 mg/kg, i.p.) and fluoxetine (5 mg/kg, i.p.) in the FST, but it did not affect the anti-depressive effect of clorgyline and maprotiline. Geniposide (10 mg/kg, i.p.) increased the levels of serotonin and 5-HIAA in striatum and serotonin in hippocampus. These results suggested that anti-depressive mechanism of GPO may be related to the increasing serotonin level in striatum and hippocampus in mice.

 

Key words: Gardenia jasminoides Ellis., Gardenia jasminoides Ellis. var. grandiflora Nakai., geniposide, forced swimming test, anti-depressive effect, monoamines.

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