African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2138

Full Length Research Paper

Evaluation of anthelmintic activity of ethanolic extracts of Carica papaya leaves using Paramphistomum cervi and Haemonchus contortus

Md. Rabiul Islam
  • Md. Rabiul Islam
  • Department of Pharmacy, Faculty of Pharmacy, Khulna University, Khulna, Bangladesh.
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Syeda Fatema Tuz Zahra
  • Syeda Fatema Tuz Zahra
  • Department of Pharmacy, Faculty of Pharmacy, Manarat International University, Dhaka, Bangladesh.
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S. M. Ibrahim Sumon
  • S. M. Ibrahim Sumon
  • Department of Pharmacy, Faculty of Pharmacy, Khulna University, Khulna, Bangladesh.
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Shahnaj Parvin
  • Shahnaj Parvin
  • Department of Pharmacy, Faculty of Pharmacy, Manarat International University, Dhaka, Bangladesh.
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Kamrul Hasan
  • Kamrul Hasan
  • Department of Pharmacy, Faculty of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
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Moudud Ahmed
  • Moudud Ahmed
  • Department of Pharmacy, Faculty of Pharmacy, Khulna University, Khulna, Bangladesh.
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Md. Abu Talha Siddique
  • Md. Abu Talha Siddique
  • Department of Pharmacy, Faculty of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.
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Tazmel Haque
  • Tazmel Haque
  • Department of Pharmacy, Faculty of Pharmacy State University of Bangladesh, Dhaka Bangladesh.
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  •  Received: 19 February 2019
  •  Accepted: 27 May 2019
  •  Published: 08 July 2019

Abstract

The aim of this present study is to evaluate the anthelmintic activity of leaves extracts of Carica papaya using Paramphistomum cervi and Haemonchus contortus as the test worms. A range of concentrations (100, 50 and 25%) of ethanolic extracts of C. papaya were tested to assay the procedure. This is mainly applied for the determination of time of death (D) and time of paralysis (P) of the tested worms. After the analysis, it was shown that for the H. contortus at 100% concentration, the paralysis occurred within the shortest time (P=24.5 min) and death came at the lowest possible time (D=56 min). The time of death and paralysis increased at 50% (D=64 min and P=28 min) and 25% concentration (D=74 min and P=34 min), respectively compared to the Piperazine citrate (P= 24 min and D= 54) at concentration of 10 mg/ml. Here, distilled water is as a control solution. The results of this study revealed that the ethanolic extracts of the leaves of the C. papaya expressed a demonstrated paralysis significantly, and also responsible for the death of P. cervi and H. contortus especially at the higher concentration (100%) compared to the standard reference of Piperazine citrate. Therefore, from the results it is declared that the ethanolic extracts of the leaves of C. papaya showed a great anthelmintic activity against P. cervi and H. contortus worms. Hence, the present research work signifies that the leaf of C. papaya has a major anthelmintic activity and also can be used as a potent drug for its low cost and availability.

Key words: Paramphistomum cervi and Haemonchus contortus, anthelmintic, Carica papaya leaves, Albendazole.