Alzheimer's disease is one of the most common neurodegenerative diseases. Beta-amyloid plaques and neurofibrillary tangles are two important factors in Alzheimer's disease. Many cellular changes, such as oxidative stress, neuronal inflammation, and mitochondrial disorders are also seen in Alzheimer's disease, which lead to neuronal death. The flavonol in the chamomile plant (Matricaria recutita) have great effects on disorders caused by brain diseases such as Alzheimer's disease due to the production of antioxidants. In this study, the flavonoids of methanolic extract from chamomile (Matricaria recutita) were separated and purified by column chromatography and TLC methods. Flavonol from flavonoid compounds were extracted, separated and detected by spectroscopy methods (1HNMR, 13C-NMR, Mass and IR. In this study, 56 adult male rats were divided into 7 groups including control - vehicle 1 (solvent of flavonol) and vehicle 2 (solvent of streptozotocin drug) - Alzheimer's - flavonoid 120mg/kg - flavonol 250mg/kg - flavonol 400mg/kg - used. Diabetes was induced by injecting a single dose of 60 mg/kg streptozotocin intraperitoneally. Flavonol were administered for 15 days. The shuttle box device was used to measure memory and learning and the delay time in the shuttle box was recorded. The results were analyzed SPSS 22 software, ANOVA and Tukey tests. The significance of the data difference was considered at the p ? 0.05 levels. The results of the data analysis showed that doses of 50 and 100 mg/kg flavonol extracts of chamomile plant caused significant changes in the duration of the delay in entering the dark section compared to the control group. And finally, it improves the avoidance memory in rats, which does this effect probably due to the presence of compounds such as quercetin and phytoestrogens. Also, oxidative stress parameters were significantly reduced in Alzheimer's groups treated with chamomile flavonol. Plant flavonol are able to restore spatial memory function and oxidative stress parameters in groups treated with streptozotocin to normal levels.

Keywords: Alzheimer, Flavonoid, Flavonol, learning, rat