African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Orthogonal test design for optimizing the extraction of total flavonoids from Flos pueraria

Fei Cai
  • Fei Cai
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar
Chen Xiao
  • Chen Xiao
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar
Qingjie Chen
  • Qingjie Chen
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar
Changhan Ouyang
  • Changhan Ouyang
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar
Ruixue Zhang
  • Ruixue Zhang
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar
Jiliang Wu
  • Jiliang Wu
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar
Chao Liu
  • Chao Liu
  • Hubei Province Key Laboratory on Cardiovascular, Cerebrovascular, and Metabolic Disorders, Hubei University of Science and Technology, Xianning, 437100, China.
  • Google Scholar


  •  Accepted: 16 December 2013
  •  Published: 08 January 2014

References

Bai X, Xie Y, Liu J, Qu J, Kano Y, Yuan D (2010). Isolation and identification of urinary metabolites of kakkalide in rats. Drug Metab. Dispos. 38(2):281-286.
Crossref
 
Choi J, Shin MH, Park KY, Lee KT, Jung HJ, Lee MS, Park HJ (2004). Effect of kaikasaponin III obtained from Pueraria thunbergiana flowers on serum and hepatic lipid peroxides and tissue factor activity in the streptozotocin-induced diabetic rat. J. Med. Food 7(1):31-37.
Crossref
 
Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, Lai CH, Chen BH, Lee Chao PD, Wan L, Tsai FJ (2009). Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem. Biophys. Res. Commun. 378(4):683-688.
Crossref
 
Jung UJ, Lee MK, Park YB, Kang MA, Choi MS (2006). Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. Int. J. Biochem. Cell Biol. 38(7):1134-1145.
Crossref
 
Kim C, Shin S, Ha H, Kim JM (2003). Study of substance changes in flowers of Pueraria thunbergiana Benth. during storage. Arch. Pharm. Res. 26(3):210-213.
Crossref
 
Lee HW, Choo MK, Bae EA, Kim DH (2003). Beta-glucuronidase inhibitor tectorigenin isolated from the flower of Pueraria thunbergiana protects carbon tetrachloride-induced liver injury. Liver Int. 23:221-226.
Crossref
 
Koon CM, Woo KS, Leung PC, Fung KP (2011). Salviae Miltiorrhizae Radix and Puerariae Lobatae Radix herbal formula mediates anti-atherosclerosis by modulating key atherogenic events both in vascular smooth muscle cells and endothelial cells. J. Ethnopharmacol. 138(1):175-183.
Crossref
 
Lee MK, Cho SY, Jang JY, Cho MS, Jeon SM, Jang MK, Kim MJ, Park YB (2001). Effects of Puerariae Flos and Puerariae Radix extracts on antioxidant enzymes in ethanol-treated rats. Am. J. Chin. Med. 29(2):343-354.
Crossref
 
Ramassamy C (2006). Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur. J. Pharm. 545(1):51-64.
Crossref
 
Tsuchihashi R, Kodera M, Sakamoto S, Nakajima Y, Yamazaki T, Niiho Y, Nohara T, Kinjo J (2009). Microbial transformation and bioactivation of isoflavones from Pueraria flowers by human intestinal bacterial strains. J. Nat. Med. 63(3):254-260.
Crossref
 
Xiong Y, Yang Y, Yang J, Chai H, Li Y, Yang J, Jia Z, Wang Z (2010). Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanol-induced liver steatosis in mice. Toxicology 276(1):64-72.
Crossref
 
Yasuda T, Kano Y, Saito K, Ohsawa K (1995). Urinary and biliary metabolites of puerarin in rats. Biol. Pharm. Bull. 18(2):300-303.
Crossref
 
Zhu ZG, Zhang ZY,Cai GM (2009). Extraction process of total flavonoids in Pueraria lobata and anti-oxidant activity. Central South Pharm. 7(3):203-205. Chinese.