African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Neuropharmacological profile of ethanolic dried seed extract of Persea americana in mice

Idris Ajayi Oyemitan
  • Idris Ajayi Oyemitan
  • Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, 220005, Nigeria.
  • Google Scholar
Emmanuel Ojo
  • Emmanuel Ojo
  • Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, 220005, Nigeria.
  • Google Scholar
Adebola Omowumi Oyedeji
  • Adebola Omowumi Oyedeji
  • Department of Chemistry, Walter Sisulu University, Nelson Mandela Drive Campus, Mthatha, 5117, South Africa.
  • Google Scholar


  •  Received: 19 April 2016
  •  Accepted: 09 June 2016
  •  Published: 15 June 2016

References

Adeyemi OO, Akindele AJ, Yemitan OK, Aigbe FR, Fagbo FI (2010). Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen. J. Ethnopharmacol. 130(2):191-195.
Crossref

 

Adeyemi OO, Yemitan OK, Taiwo AE (2006). Neurosedative and muscle-relaxant activities of ethyl acetate extract of Baphia nitida AFZEL. J. Ethnopharmacol. 106(3):312-316.
Crossref

 
 

Adeyemi OO, Okpo SO, Ogunti OO (2002). Analgesic and anti-inflammatory effects of the aqueous extract of leaves of Persea americana Mill (Lauraceae). Fitoterapia, 73(5):375-380.
Crossref

 
 

Al-Naggar TB, Gomez-Serranillos MP, Carretero ME, Villar AM (2003). Neuropharmacological activity of Nigella sativa L. extracts. J. Ethnopharmacol. 88(1):63-68.
Crossref

 
 

Olatokunboh AO, Kayode YO, Adeola OK (2009). Anticonvulsant activity of Rauvolfia vomitoria (Afzel). Afr. J. Pharm Pharmacol. 3(6):319-322.

 
 

Antia BS, Okokon JE, Okon PA (2005). Hypoglycemic activity of aqueous leaf extract of Persea americana Mill. Indian J. Pharmacol. 37(5):325.
Crossref

 
 

Arukwe U, Amadi BA, Duru MKC, Agomuo EN, Adindu EA, Odika PC, Anudike J(2012). Chemical composition of Persea americana leaf, fruit and seed. IJRRAS.11(2):346-349.

 
 

Asaolu MF, Asaolu SS, Fakunle JB, Emman-Okon BO, Ajayi EO, Togun RA (2010). Evaluation of in-vitro antioxidant activities of methanol extracts of Persea americana and Cnidosculus aconitifolius. Pak. J. Nutr. 9(11):1074-1077.
Crossref

 
 

Balunas MJ, Kinghorn AD (2005). Drug discovery from medicinal plants. Life Sci. 78(5):431-441.
Crossref

 
 

Bhattacharya PK, Bhattacharya L, Jain RK, Agarwal RC (2003). Post anaesthesia shivering (PAS): A review. Indian J. Anaesth. 47(2):88-93.

 
 

Castel-Branco MM, Alves GL, Figueiredo IV, Falcão A, Caramona MM (2009). The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic drugs. Methods Find. Exp. Clin. Pharmacol. 31(2):101-106.
Crossref

 
 

Chen H, Morrell PL, Ashworth VE, de la Cruz M, Clegg MT (2009). Tracing the geographic origins of major avocado cultivars. J. Heredity 100(1):56-65.
Crossref

 
 

de Carvalho RSM, Duarte FS, de Lima TCM (2011). Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice. Behav. Brain Res. 221(1):75-82.
Crossref

 
 

De Sarro A, Cecchetti V, Fravolini V, Naccari F, Tabarrini O, De Sarro G (1999). Effects of novel 6-desfluoroquinolones and classic quinolones on pentylenetetrazole-induced seizures in mice. Antimicrob. Agents Chemother. 43(7):1729-1736.

 
 

Sousa DPD, Nóbrega FF, de Morais LC, Almeida RND (2009). Evaluation of the anticonvulsant activity of terpinen-4-ol. Z. Naturforsch. C. 64(1-2):1-5.
Crossref

 
 

Dzeufiet PD, Mogueo A, Bilanda DC, Aboubakar BF, Tédong L, Dimo T, Kamtchouing P (2014). Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model. BMC Complement. Altern. Med. 14:507.
Crossref

 
 

Edem D1, Ekanem I, Ebong P (2009). Effect of aqueous extracts of alligator pear seed (Persea americana Mill.) on blood glucose and histopathology of pancreas in alloxan-induced diabetic rats. Pak. J. Pharm. Sci. 22(3):272-6.

 
 

Ezuruike UF, Prieto JM (2014). The use of plants in the traditional management of diabetes in Nigeria:Pharmacological and toxicological considerations. J. Ethnopharmacol. 155(2):857-924.
Crossref

 
 

Fabricant DS, Farnsworth NR (2001). The value of plants used in traditional medicine for drug discovery. Environ. Health Perspect. 1:69-75.
Crossref

 
 

Gavhane YN, Yadav AV (2012). Loss of orally administered drugs in GI tract. Saudi Pharm. J. 20(4):331-44
Crossref

 
 

Gonzalez-Trujano ME, Carrera D, Ventura-Martinez R, Cedillo-Portugal E, Navarrete A (2006). Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice. J. Ethnopharmacol. 106(1):129-135.
Crossref

 
 

Guo L, Wang S, Zhang J, Yang G, Zhao M, Ma W, Huang L (2013). Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism. Sci. China Life Sci. 56(11):1047-1056.
Crossref

 
 

Hegde K, Thakker SP, Joshi AB, Shastry CS, Chandrashekhar KS (2009). Anticonvulsant activity of Carissa carandas Linn. root extract in experimental mice. Trop. J. Pharm. Res. 8:(2).
Crossref

 
 

Helliön-Ibarrola MC, Ibarrola DA, Montalbetti Y, Villalba D, Heinichen O, Ferro EA (1999). Acute toxicity and general pharmacological effect on central nervous system of the crude rhizome extract of Kyllinga brevifolia Rottb. J. Ethnopharmacol. 66(3):271-276.
Crossref

 
 

Herrera-Ruiz M, Gutiérrez C, Jiménez-Ferrer JE, Tortoriello J, Mirón G, León I (2007). Central nervous system depressant activity of an ethyl acetate extract from Ipomoea stans roots. J. Ethnopharmacol. 112(2):243-247.
Crossref

 
 

Imafidon KE, Amaechina FC (2010). Effects of aqueous seed extract of Persea americana Mill.(avocado) on blood pressure and lipid profile in hypertensive rats. Adv. Biol. Res. 4(2):116-121.

 
 

Jiménez-Arellanes A, Luna-Herrera J, Ruiz-Nicolás R, Cornejo-Garrido J, Tapia A, Yépez-Mulia L (2013). Antiprotozoal and antimycobacterial activities of Persea americana seeds. BMC Complement. Altern. Med. 13:109.
Crossref

 
 

Deraedt R, Jouquey S, Delevallée F, Flahaut M (1980). Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J Pharmacol. 11:61(1):17-24.

 
 

Hegde K, Thakker SP, Joshi AB, Shastry CS, Chandrashekhar KS (2009). Anticonvulsant activity of Carissa carandas Linn. root extract in experimental mice. Trop. J. Pharma. Res. 8(2).

 
 

Koffi N, Kouakou EA, Dodiomon S (2009). Effect of aqueous extract of Persea americana seeds on the glycemia of diabetic rabbits. Eur. J. Sci. Res. 26(3):76-385.

 
 

Leite JJG, Brito ÉHS, Cordeiro RA, Brilhante RSN, Sidrim JJC, Bertini L M, Rocha MFG (2009). Chemical composition, toxicity and larvicidal and antifungal activities of Persea americana (avocado) seed extracts. Rev. Soc. Bras. Med. Trop. 42(2):110-113.
Crossref

 
 

Lorke D (1983). A new approach to practical acute toxicity testing. Arch. Toxicol. 54(4):275-287.
Crossref

 
 

Löscher W, Schmidt D (1988). Which animal model should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2(3):145-81.
Crossref

 
 

Macdonald RL, Kelly KM (1995). Antiepileptic drug mechanisms of action. Epilepsia. 36(2):S2-12.
Crossref

 
 

Matsusaka Y, Kawabata J, Kasai T (2003). Antioxidative constituents in avocado (Persea americana Mill.) seeds. J. Jpn. Soc. Food Sci. Technol. 50(11):550-552.
Crossref

 
 

Mimura M, Namiki A, Kishi R, Ikeda T, Miyake H (1990). Antagonistic effect of physostigmine on ketamine-induced anaesthesia. Psychopharmacology (Berl). 102(3):399-403.
Crossref

 
 

Mir AM, Sawhney SS, Jassal MMS (2013). Qualitative and quantitative analysis of phytochemicals of Taraxacum officinale. Wudpecker J. Pharm. Pharmacol. 2(1):001-005.

 
 

Nagashima K (2006). Central Mechanisms for Thermoregulation in a Hot Environment. Ind. Health 44(3):359-67.
Crossref

 
 

Nayak BS, Raju SS, Chalapathi Rao AV. (2008). Wound healing activity of Persea americana (avocado) fruit: A preclinical study on rats. J. Wound Care 17(3):123-6.
Crossref

 
 

Nevins ME, Arnolde, SM (1989). A comparison of the anticonvulsant effects of competitive and non-competitive antagonist of the N-methyl-d-aspartate receptor. Brain Res. 503(1):1-4
Crossref

 
 

Newman DJ, Cragg GM (2012). Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Natural Prod. 75(3)311-335.
Crossref

 
 

Nwaogu LA, Alisi CS, Ojiako OA (2009). Studies on the nutritional and phytochemical properties of Persea americana seed. Bio-Res. 6(1):320-322.
Crossref

 
 

Odo CE, Nwodo OF, Joshua PE, Ugwu OP, Okonkwo CC (2013). Acute toxicity investigation and anti-diarrhoeal effect of the chloroform–methanol extract of the seeds of Persea americana in albino rats. Iran J. Pharm. Res. 13(2):651-658.
Crossref

 
 

Ojewole JA, Amabeoku, GJ (2006). Anticonvulsant effect of Persea americana Mill (Lauraceae) (Avocado) leaf aqueous extract in mice. Phytother Res. 20(8):696-700.
Crossref

 
 

Okonta M, Okonta L, Aguwa CN (2007). Blood glucose lowering activities of seeds of Persea americana on alloxan induced diabetic rats. Nigerian J. Nat. Prod. Med. 11:26-28.

 

Onigbogi O, Ajayi AA, Ukponmwan OE (2000). Mechanisms of chloroquine-induced body scratching behaviour in rats; Evidence of involvement of endogenous opioid peptides. Pharmacol. Biochem. Behav. 65(2):333-337.
Crossref

 

Owolabi MA, Jaja SI, Coker HA (2005). Vasorelaxant action of aqueous extract of the leaves of Persea americana on isolated thoracic rat aorta. Fitoterapia. 76(6):567-573.
Crossref

 
 

Oyemitan IA, Iwalewa EO, Akanmu MA, Olugbade TA (2008). Sedative, Hypothermic and Muscle Relaxant Effects of the Essential Oil of Dennettia tripetala G. Baker (Annonaceae) in Mice. Ife J. Sci. 10(1):1-9.

 
 

Padilla-Camberos E, Martínez-Velázquez M, Flores-Fernández JM, Villanueva-Rodríguez S (2013). Acute toxicity and genotoxic activity of avocado seed extract (Persea americana Mill cv Hass). Available at: http://dx.doi.org/10.1155/2013/245828.
Crossref

 
 

Park JH, Cha HY, Seo JJ, Hong JT, Han K, Oh KW (2005). Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Progress in Neuro-Psychopharmacol. Biol. Psiquiatr. 29(6):895-900.

 
 

Pellow S, Chopin P, File SE, Briley M (1985). Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. Neurosci. Methods 14(3):149-167.
Crossref

 
 

Pond SM, Tozer TN (1984). First-pass elimination. Basic concepts and clinical consequences. Clin. Pharmacokinet. 9(1):1-25.
Crossref

 
 

Pourgholami MH, Kamalinejad M, Javadi M, Majzoob S, Sayyah M (1999). Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. J. Ethnopharmacol. 64(2):167-171.
Crossref

 
 

Ramanjaneyulu R, Ticku MK (1984). Interactions of pentylenetetrazol and tetrazole analogues with the picrotoxin site of the benzodiazepine-GABA receptor ionophore complex. Eur. J. Pharmacol. 98: 337-345.
Crossref

 
 

Rang HP, Dale MM, Ritter JM, Moore PK (2007). Pharmacology, 6th ed. Churchill Livingstone. Edinburgh. pp. 557-587.
Crossref

 
 

Rodríguez- Carpena JG, Morcuende D, Andrade MJ et al. (2011). Avocado (Persea americana Mill.) Phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties. J. Agric. Food Chem. 59(10):5625-5635.
Crossref

 
 

Rowlands DB, Stallard TJ, Watson RDS et al. (1980). The influence of physical activity on arterial pressure during ambulatory recordings in man. Clin. Sci. 58:116-117.
Crossref

 
 

Shenoy AK, Miyahara JT, Swinyard EA, Kupferberg HJ (1982). Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats. Epilepsia 23(4):399-408.
Crossref

 
 

Silva J, Abebe W, Sousa SM, Duarte VG, Machado MIL, Matos FJA (2003). Analgesic and anti-inflammatory effects of essential oil of Eucalyptus. J. Ethnopharmacol. 89(2):277-283.
Crossref

 
 

Sivam SP, Nabeshima T, Ho IK (2004). Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: A study with muscimol. J. Neurosci. Res. 7(1):37-47.
Crossref

 
 

Söderpalm B, Hjorth S, Engel JA (1989). Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test. Pharmacol. Biochem. Behav. 32(1):259-265.
Crossref

 
 

Sousa DPD, Nóbrega FF, de Morais LC, Almeida RND (2009). Evaluation of the anticonvulsant activity of terpinen-4-ol. Z. Naturforsch. C. 64(1-2):1-5.
Crossref

 
 

Swinyard EA, Woodhead JH, White HS, Franklin MR (1989). Experimental selection, quantification and evaluation of anticonvulsants. In: Levy R, Mattson R, Meldrum BS, Penry JK, Dreifuss FE. (Eds), Antiepileptic Drugs, 3rd ed., Raven Press New York. pp 85-102.

 
 

Takeda H, Tsuji M, Matsumiya T (1998). Changes in head-dipping behaviour in the hole-board test reflect the anxiogenic and/or anxiolytic state in mice. Euro. J. Pharmacol. 350(1):21-29.
Crossref

 
 

Takenaga F, Matsuyama K, Abe S, Torii Y, Itoh S (2008). Lipid and fatty acid composition of mesocarp and seed of avocado fruits harvested at northern range in Japan. J. Oleo. Sci. 57(11):591-597.
Crossref

 
 

Ukwe CV, Nwafor SV (2005). Anti-ulcer activity of aqueous leaf extract of Persea americana (family-Lauraceae). Nig. J. Pharm. Res. 3(1):91-95.
Crossref

 
 

Vale TG, Matos FJA, De Lima TCM, Viana GSB (1999). Behavioural effect of essential oils from Lippia alba (Mill) N.E. Brown Chemotypes. J. Ethnopharmacol. 167(2):127-133.
Crossref

 
 

Viana GS, Bandeira MA, Matos FJ. (2003). Analgesic and anti-inflammatory effects of chalcones isolated from Myracrodruon urundeuva Allem. Phytomed. 10(2-3):189-95.
Crossref

 
 

Wang W, Bostic TR, Gu L (2010). Antioxidant capacities, procyanidins and pigments in avocados of different strains and cultivars. Food Chem. 122(4):1193-1198.
Crossref

 
 

Yadav AV, Kawale LA, Nade VS (2008).Effect of Morus alba L. (mulberry) leaves on anxiety in mice. Indian J. Pharmacol. 40(1):32-6.
Crossref

 
 

Zapata-Sudo G, Mendes TC, Kartnaller MA, Fortes TO, Freitas NF, Kaplan MA, Sudo RT (2010). Sedative and anticonvulsant activities of methanol extract of Dorstenia arifolia in mice. J. Ethnopharmacol. 130(1):9-12.
Crossref