African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Reversal of phenytoin induced hepatotoxicity by alpha lipoic acid in rats

Ganesan Rajalakshmi Saraswathy*
  • Ganesan Rajalakshmi Saraswathy*
  • Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.
  • Google Scholar
Eswaran Maheswari
  • Eswaran Maheswari
  • Department of Pharmacy Practice, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.
  • Google Scholar
Thakur Santhrani
  • Thakur Santhrani
  • Division of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam (Women?s University), Tirupati, Andhra Pradesh, India.
  • Google Scholar
Jayaraman Anbu
  • Jayaraman Anbu
  • Department of Pharmacology, Faculty of Pharmacy, M.S. Ramaiah University of Applied Sciences, Bangalore, Karnataka, India.
  • Google Scholar


  •  Received: 20 January 2014
  •  Accepted: 26 January 2015
  •  Published: 22 February 2015

References

Al-Attar AM (2010). Physiological and histopathological investigations on the effects of ALA in rats exposed to malathion. J. Biomed. Biotechnol. 1-8.
crossref
 
Aldenhovel HG (1988). The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma glutamyl transferase, aspartate aminotransferase, alanine aminotransferase and ALP. Eur. Arch. Psychiatry Neurol. Sci. 237(5):312-316.
crossref
 
Bajpai M, Roskos LK, Shen DD, Levy RH (1996). Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of Phenytoin to its major metabolite. Drug Metab. Dispos. 24(12):1401-1403.
Pubmed
 
Bavdekar SB, Muranjan MN, Gogtay NJ, Kantharia V, Kshirsagar NA (2004). Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. Ann. Pharmacother. 38(10):1648-1650.
crossref
 
Beer RF, Sizer IW (1952). A spectrophotometric method for measuring the breakdown hydrogen peroxide by catalase. J. Biol. Chem. 195(1):133-140.
 
Björnsson E (2008). Hepatotoxicity associated with antiepileptic drugs. Acta Neurol. Scand. 118(5):281-290.
crossref
 
Chatterjee M, Sil PC (2006). Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide induced oxidative stress in vivo. Indian J. Biochem. Biophys. 43(5):299-305.
Pubmed
 
Doumasa BT, Watson WA, Biggs HG (1971). Albumin standards and the measurement of serum albumin with bromocresol green. Clin. Chim. Acta 31(1):87-96.
crossref
 
Dreifuss FE, Langer DH (1987). Hepatic considerations in the use of antiepileptic drugs. Epilepsia 28(2):S23-S29.
crossref
 
Eraslan G, Kanbur M, Silici S (2009). Effect of carbaryl on some biochemical changes in rats: the ameliorative effect of bee pollen. Food Chem. Toxicol. 47(1):86-91.
crossref
 
Foo NP, Lin SH, Lee YH, Wu MJ, Wang YJ (2011). α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β. Toxicology 282(1-2):39-46.
crossref
 
Gella FJ, Olivella T, Cruz Pastor M, Arenas J, Moreno R, Dueban R, Gomez JA (1985). A simple procedure for routine determination of aspartate aminotrasferase and alanine aminotransferase with pyridoxal phosphate. Clin. Chim. Acta 153(3):241-247.
crossref
 
George J, Farrell GC (1994). Anticonvulsivant hepatotoxicity. In: Farrell GC (ed.), Drug-induced Liver Disease. Churchill Livingstone, Edinburgh, London. pp. 143-144.
 
Gokcimen A, Gulle K, Demirin H, Bayram D, Kocak A, Altuntas I (2007). Effects of diazinon at different doses on rat liver and pancreas tissues. Pestic. Biochem. Physiol. 87(2):103-108.
crossref
 
Gomall AG, Bardawill CJ, David MM (1949). Determination of serum proteins by means of biuret reaction. J. Biol. Chem. 177(2):751-766.
 
Harden CL (2000). Therapeutic safety monitoring: what to look for and when to look for it. Epilepsia 41(8):S37-S44.
crossref
 
Hesham AEB (2007). Lipoic acid attenuates DNA fragmentation, oxidative stress and liver injury induced by tamoxifen in rats. Asian J. Tradit. Med. 2:175-188.
 
Kalapos MP (2002). Carbamazepine provoked hepatotoxicity and possible etiopathological role of glutathione in the events. Retrospective review of old data and call for new investigation. Adv. Drug React. Toxicol. Rev. 21(3):123-141.
crossref
 
Kass GE (2006). Mitochondrial involvement in drug-induced hepatic injury. Chem. Biol. Interact. 163(1), 145-159.
crossref
 
Kazamatsuri H (1970). Elevated serum ALP levels in epilepsy during diphenylhydantoin therapy. N. Engl. J. Med. 283(25):1411-1412.
crossref
 
Li Y, Powers C, Jiang N, Chopp M (1998). Intact, injured, necrotic and apoptotic cells after focal cerebral ischemia in the rat. J. Neurol. Sci. 156(2):119-132.
crossref
 
Liu CB, Feng YH, Ye GH, Xiao M (2010). Effects of α-lipoic acid and vitamin C on oxidative stress in rat exposed to chronic arsenic toxicity. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28(12):891-894.
Pubmed
 
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193(1):265-75.
Pubmed
 
Madden S, Maggs JL, Park BK, (1996). Bioactivation of carbamazepine in the rat invivo. Evidence for the formation of reactive arene oxide(s). Drug Metab. Dispos. 24(4):469-479.
Pubmed
 
Marklund S, Marklund G (1974). Involvement of the superoxide anion radical in the auto oxidation of pyragallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47(3):469-474.
crossref
 
Ncibi S, Othman MB, Akacha A, Krifi MN, Zourgui L (2008). Opuntia ficus indica extract protects against chlorpyrifos-induced damage on mice liver. Food Chem. Toxicol. 46(2):797-802.
crossref
 
Packer L, Witt EH, Tritschler HJ (1995). Alpha-lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19(2):227-250.
crossref
 
Pari L, Murugavel P (2004). Protective effect of alpha lipoic acid against chloroquine induced hepatotoxicity in rats. J. Appl. Toxicol. 24(1):21-26.
crossref
 
Pearlman FC, Lee RTY (1974). Detection and measurement of total bilirubin in serum with use of surfactants as solubilizing agents. Clin. Chem. 20(4):447-453.
Pubmed
 
Rosalki SB, Foo AY, Burlina A, Prellwitz W, Strieber P, Neumeier D, Klein G, Poppe WA, Bodenmuller H (1993). Multicentre evaluation of iso ALP test kit for measurement of bone alkaline phosphatase ativity in serum and plasma. Clin. Chem. 39(4):648-652.
Pubmed
 
Roy D, Snodgrass WR (1988). Phenytoin metabolic activation: role of cytochrome P450, glutathione, age, and sex in rats and mice. Res. Commun. Chem. Pathol. Pharmacol. 59:173-190.
Pubmed
 
Saad EI, El-Gowilly SM, Sherhaa MO, Bistawroos AE (2010). Role of oxidative stress and nitric oxide in the protective effects of alpha-lipoic acid and aminoguanidine against isoniazid rifampicin induced hepatotoxicity in rats. Food Chem. Toxicol. 48(7):1869-1875.
crossref
 
Sallie R, Tredger JM, Willam R (1991). Drugs and the Liver. Biopharm. Drug Dispos. 12:251-259.
crossref
 
Santos NA, Medina WS, Martins NM, Rodrigues MA, Curti C, Santos AC (2008). Involvement of oxidative stress in the hepatotoxicity induced by aromatic antiepileptic drugs. Toxicol. Vitro 22(8):1820-1824.
crossref
 
Saraswathy GR, Maheswari E, Santhrani T (2010). Effect of Vitamin C supplementation on phenytoin induced hepatotoxicity. Glob. J. Pharmacol. 4(3):127-135.
 
Sedlak J, Lindsay RH (1968). Estimation of total, protein bound & non-protein SH groups in tissue with Ellman's reagent. Anal. Biochem. 25(1):192-205.
crossref
 
Shear NH, Spielberg SP (1988). Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J. Clin. Investig. 82(6):1826-1832.
crossref
 
Smythe MA, Umstead GS (1989). Phenytoin hepatotoxicity: a review of the literature. DICP 23(1):13-18.
Pubmed
 
Kalender S, Gokce Uzun F, Durak D, Demir F, Kalender Y (2010). Malathion-induced hepatotoxicity in rats: The effects of vitamins C and E. Food Chem. Toxicol. 48(2):633-638.
crossref
 
Walia KS, Khan EA, Ko DH, Raza SS, Khan YN (2004). Side effects of antiepileptics - a review. Pain Pract. 4(3):194-203.
crossref
 
Walker M (2005). Status epilepticus: an evidence based guide. BMJ 331(7518):673–677.
crossref
 
Zaccara G, Franciotta D, Perucca E (2007). Idiosyncratic adverse reactions to antiepileptic drugs. Epilepsia 48(7):1223-1244.
crossref