African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2288

Full Length Research Paper

Gender-related differences in pharmacokinetic parameters of tramadol following intravenous and subcutaneous administration in dogs

Buhari Salisu
  • Buhari Salisu
  • Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Nigeria.
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Kalthum Hashim
  • Kalthum Hashim
  • Faculty of Veterinary Medicine, Universiti Malaysia Kelantan, 16100 Kota Bharu Kelantan, Malaysia.
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Goh Yong Meng
  • Goh Yong Meng
  • Department of Veterinary Preclinical Studies, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
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Gan Siew Hua
  • Gan Siew Hua
  • Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan, Malaysia.
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  •  Received: 12 July 2015
  •  Accepted: 21 October 2015
  •  Published: 15 November 2015

References

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Gan SH, Ismail R (2001). Validation of a high-performance liquid chromatography method for tramadol and o-desmethyltramadol in human plasma using solid-phase extraction. J. Chromatogr. B Biomed. Sci. Appl. 759(2):325-335.
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Gan SH, Ismail R, Wan Adnan WA, Wan Z (2002). Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid- liquid extraction. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 772(1):123-129.
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Hui-Chen L, Shu-Min J, Yong-Li W (2003). Gender-related differences in pharmacokinetics of enantiomers of trans-tramadol and its active metabolite, trans-O-demethyltramadol, in rats. Acta Pharmacol. Sin. 24(12):1265-1269.

  
 

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KuKanich B, Papich MG (2004). Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. J. Vet. Pharmacol. Ther.
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Maris AF, Franco JL, Mitozo PA, Paviani G, Borowski C, Trevisan R, Uliano-Silva M, Farina M, Dafre AL (2010). Gender effects of acute malathion or zinc exposure on the antioxidant response of rat hippocampus and cerebral cortex. Basic Clin. Pharmacol. Toxicol. 707(6):965-970.
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Soldin OP, Mattison DR (2009). Sex Differences in Pharmacokinetics and Pharmacodynamics. Clin. Pharmacokinet 48(3):143-157.
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Tanaka E (1999). Gender-related differences in pharmacokinetics and their clinical significance. J. Clin. Pharm. Ther. 24(5):339- 346.
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Yang X, Zhang B, Molony C, Chudin E, Hao K, Zhu J, Gaedigk A, Suver C, Zhong H, Leeder JS, Guengerich FP, Strom SC, Schuetz E, Rushmore TH, Ulrich RG, Slatter JG, Schadt EE, Kasarskis A, Lum PY (2010). Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver. Genome Res. 20(8):1020- 1036.
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