African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2250

Full Length Research Paper

Imbalance of the oxidant - antioxidant status by aspartame in the organs of immune system of Wistar albino rats

Arbind Kumar Choudhary
  • Arbind Kumar Choudhary
  • Department of Physiology, Dr. ALM.PG. Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamilnadu, India.
  • Google Scholar
Rathinasamy Sheela Devi*
  • Rathinasamy Sheela Devi*
  • Department of Physiology, Dr. ALM.PG. Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamilnadu, India.
  • Google Scholar


  •  Published: 28 February 2014

References

Walzem RL, Clifford AJ (1988). Folate defiency in rats fed diets containing free amino acid or intact proteins. J. Nutr. 118:1089-1096. Pubmed
 
Bains JS, Shaw CA (1997). Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Brain Res. Rev. 25:335.
Crossref
 
Bancroft JD, Gamble M (2002). Theory and Practice of Histological techniques. 5th edn Churchill Livingstone London. pp: 621-636.
 
Bergendi L, Benes L, Durackova Z, Ferencik M (1999). Chemistry, physiology and pathology of free radicals. Life Sci. 65:1865–1874.
Crossref
 
Bhattacharjee R, Sil PC (2006). The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother. Res 20:595–601.
Crossref
 
Blough NV, Zafiriou N (1995). Reaction of superoxide with nitrix oxide to form peroxynitrite in alkaline aqueous solution. Inorg. Chem. 24:3502-5.
Crossref
 
Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254
Crossref
 
Britton KT, Segal DS, kuczenski R, Havger R (1992). Dissociation between in vivo hippocampal NE response and behavioral neuro endocrine responses to noise stress in rats. Brain Res. 574:125-30.
Crossref
 
Briviba K, Sies H (1994). Non enzymatic Antioxidant Defense Systems. In: Frei B (ed.), Natural Antioxidants in Human Health and Disease. San Diego: Academic Press 4:107–128.
 
Butchko HH, Stargel WW (2001). Aspartame: scientific evaluation in the post marketing period. Regul. Toxicol. Pharmacol. 34(3): 221- 233.
Crossref
 
Chang JR, Xu DQ (2006). Effects of formaldehyde on the activity of superoxide dismutase and glutathione peroxidase and the concen-tration of malondialdehyde. Wei Sheng Yan Jiu. Sept. 35(5):653- 655. Pubmed
 
Cheese-man KH (1993). Mechanisms and effects of lipid peroxidation. Mol. Aspects Med. 14(3):191-197.
Crossref
 
Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J, Abramson SB (1994). Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary. Proc. Nat. Acad. Sci. USA 91:3680.
Crossref
 
Davoli E, Cappellini L, Airoldi L, Fanelli R(1986). Serum methanol concentrations in rats and in men after a single dose of aspartame. Food Chem. Toxicol. 24:187–189.
Crossref
 
European Food Safety Authority (EFSA) (2006). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to a new long-term carcinogenicity study on aspartame. EFSA J 356:1–44. View
 
Feldman S, Conforti N (1980). Participation of dorsal hippocampus in the glucocorticoids feedback effect on adreno cortical activity. Neuroendocrinology 30:52–55.
Crossref
 
Fridovich I (1975). Superoxide dismutase. Annu Rev. Biochem. 44:147-159.
Crossref
 
Garriga MM, Metcalfe DD (1988). Aspartame intolerance. Ann. Allergy 61:63.
Pubmed
 
Gulec M, Gurel A, Armutcu F (2006). Vitamin E protects against oxidative damage caused by formaldehyde in the liver and plasma of rats. Mol. Cell Biochem. 290(1-2):61-67.
Crossref
 
Hernanz A, Collazos ME, de la Fuente M (1990). Effect of age, culture medium and lymphocyte presence on ascorbate content of peritoneal macrophages from mice and guinea pigs during phagocytosis. Int Arch. Allergy Appl. Immunol. 91(2):166-70.
Crossref
 
Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M (2005). Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol induced kindling in mice. Neuropharmacology 49:456-64.
Crossref
 
Jaeschke H (2003). The role of reactive oxygen species in hepatic ischaemia-reperfusion injury and preconditioning. J. Investig. Surg. 16:127-40.
Crossref
 
Karim A, Burns T (1996). Metabolism and pharmacokinetics of radio labeled aspartame in normal subjects. In: Tschanz C, Butchko HH, Stargel WW, Kotsonis FN (eds.), The clinical evaluation of a food additive. Assessment of aspartame. Boca Raton, New York, London.
 
Khan SM (2006). Protective effect of black tea extract on the levels of lipid peroxidation and antioxidant enzymes in liver of mice with pesticideinduced liver injury. Cell Biochem. Funct. 24:327–332.
Crossref
 
Koppal T, Drake J, Yatin S, Jordan B, Varadarajan S, Bettenhausen L, Butterfield DA (1999). Peroxynitrite-induced alterations in synaptosomal membrane proteins: insight into oxidative stress in Alzheimer's disease. J. Neurochem. 72:310.
Crossref
 
Liu J, Mori A (1999). Stress, aging and brain oxidative damage. Neurochem. Res. 24:1479-1497.
Crossref
 
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein mea-surement with the Folin phenol reagent. J. Biol. Chem. 193: 263–275. View
 
Marklund S, Marklund G (1974). Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47:469–471.
Crossref
 
Matsumoto K, Yobimoto K, Huong NT, Abdel-Fattah M, Hien TV, Watanabe H (1999). Psychological stress-induced enhancement of lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice. Brain Res. 839:74-84.
Crossref
 
Ming HSY, Craig A, Meadows, Shirley W, Thenen (1989). Methotrexate effects on folate status and the deoxyuridine suppression test in rats. Nutr. Res. 9(4):431–444. View
 
Moron MS, Difieree JW, Mannervik KB (1979). Levels of glutathione, reductase and glutathione-S-transferase activities in rat lung and liver. Biochem. Biophys. Acta 582:67–68.
Crossref
 
Mourad M (2011). Effect of aspartame on some oxidative stress para-meters in liver and kidney of rats. Afr. J. Pharm. Pharmacol. 5(6):678-672.
Crossref
 
Murray RK, Granner DK, Mayes PA, Rodwell VW (2003). Harper's Illustrated Biochemistry, 26th edition. The McGraw-Hill Companies Inc.
 
Nakao H, Umebayashi C, Nakata M, Nishizaki Y, Noda K, Okanao Y, Oyama Y (2003). Formaldehyde induced shrinkage of rat thymocyte. J. Pharmacol. Sci. 91: 83-6.
Crossref
 
Niki E (1991). Vitamin C as an antioxidant. World Rev. Nutr. Diet. 64:1-30.
Pubmed
 
Ohkawa H, Osishi N, and Yagi K (1979). Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction. Anal. Biochem. 251:351–358.
Crossref
 
Omaye ST, Turabull JD, Sanberlib HE (1979). Selected method for the determination of ascorbic acid in animal cells, tissues and fluids. Meth. Enzymol. 62: 1–11.
Crossref
 
Oppermann JA (1984). Aspartame metabolism in animals. In Stegink LD, Filer LJ Jr eds. Aspartame, physiology and biochemistry. Marcel Dekker, Inc. pp. 141-59.
 
Oyama Y, Sakai H, Arata T, OkanoY, Akaike N, Sakai K, Noda K (2002). Cytotoxic effects of methanol, formaldehyde and formate on dissociated rat thymocytes: a possibility of aspartame toxicity. Cell Biol. Toxicol. 18(1):43-50.
Crossref
 
Pankow D, Jagielki S (1993). Effect of methanol on modifications of hepatic glutathione concentration on the metabolism of dichloro-methane to carbon monoxide in rats. Hum. Exp. Toxicol. 12:227-231.
Crossref
 
Parthasarathy JN, Ramasundaram SK, Sundaramahalingam M, Pathinasamy SD (2006). Methanol induced oxidative stress in rat lymphoid organs. J. Occup. Health 48:20-27.
Crossref
 
Pieri C, Recchioni R, Moroni F (1993). Age-dependent modifications of mitochondrial trans-membrane potential and mass in rat splenic lymphocytes during proliferation. Mech. Ageing Dev. 70: 201–212.
Crossref
 
Pigeolet E, Corbisler P, Houbion A, Lambert D, Mitchiels C, Raes M, Zachary JR (1990). Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech. Ageing Dev. 51: 283– 297.
Crossref
 
Rabinowitz JC, Pricer WE (1956). "Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid". J. Am. Chem. Soc. 78(21):5702–5704.
Crossref
 
Rotruck JT, Pope AL, Ganther HE (1973). Selenium, biochemical role as a component of glutathione peroxidase purification and assay. Science 179:588–590.
Crossref
 
Sies H (1991). Oxidative Stress: Oxidants and Antioxidants. Academic Press, San Diego, California regulations, and toxicological and epidemiological studies. Crit. Rev. Toxicol. 37(8):629-727.
 
Sinha AK (1972). Colorimetric assay of catalase. Anal. Biochem. 47:389–394.
Crossref
 
Skrzydlewksa E, Szynaka B (1996). ultrastructral elevation of lysosome and biochemical change in cathepsin D distribution in hepatocytes in methanol intoxication. Roczniki Akademii Medycznej W Bialymstoku 42:47-55.
 
Stegink LD, Brummel MC, McMartin KE, Martin G - Amat, Filer LJ, Jr., Baker GL, Tephly TR (1981). Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame. J. Toxicol. Environ. Health 7:281–290.
Crossref
 
Stegink LD, Filer LJ (1996). Effects of aspartame ingestion on plasma aspartate, phenylalanine and methanol concentrations in normal adults. In: Tschanz C, Butchko HH, Stargel WW, Kotsonis FN (edts).The clinical evaluation of a food additive. Assessment of aspartame. Boca Raton, New York, London, Tokyo: CRC Press. pp. 67-86.
 
Vidyasagar J, Karunakar N, Reddy MS, Rajnarayana K, Surender T, Krishna DR (2004). Rajnarayana K, Surender T, Krishna DR (eds.), Oxidative stress and antioxidant status in acute organophosphorous insecticide poisoning. Indian J. Pharmacol. 36:76–79. View
 
Zararsiz I, Sarsilmaz M, Tas U, Kus I, Meydan S, Ozan E (2007). Protective effect of melatonin against formaldehyde- induced kidney damage in rats. Toxicol. Ind. Health, 23(10):5
Crossref