African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2284

Full Length Research Paper

Immunomodulatory effect of Artemisia annua and Moringa oleifera on viral load among PLWH on antiretroviral therapy in Uganda

Silvano Twinomujuni
  • Silvano Twinomujuni
  • Department of Pharmacy, Mbarara University of Science and Technology, P. O. Box 1410 Mbarara, Uganda.
  • Google Scholar
Patrick E. Ogwang
  • Patrick E. Ogwang
  • Department of Pharmacy, Mbarara University of Science and Technology, P. O. Box 1410 Mbarara, Uganda.
  • Google Scholar
Esther C. Atukunda
  • Esther C. Atukunda
  • Department of Pharmacy, Mbarara University of Science and Technology, P. O. Box 1410 Mbarara, Uganda.
  • Google Scholar
Amanya Martin
  • Amanya Martin
  • Department of Pharmacy, Mbarara University of Science and Technology, P. O. Box 1410 Mbarara, Uganda.
  • Google Scholar
Mary Nantongo
  • Mary Nantongo
  • Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, P. O. Box 7062 Kampala, Uganda.
  • Google Scholar
Richard Otim
  • Richard Otim
  • Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, P. O. Box 7062 Kampala, Uganda.
  • Google Scholar
Rose Nabatanzi
  • Rose Nabatanzi
  • Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, P. O. Box 7062 Kampala, Uganda.
  • Google Scholar
Felicitas Roelofsen
  • Felicitas Roelofsen
  • Action for Natural Medicine in the Tropics (ANAMED INTERNATIONAL), Germany.
  • Google Scholar
Bernard Bagaya
  • Bernard Bagaya
  • Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, P. O. Box 7062 Kampala, Uganda.
  • Google Scholar
Joel Bazira
  • Joel Bazira
  • Department of Microbiology, Mbarara University of Science and Technology, P. O. Box 1410 Mbarara, Uganda.
  • Google Scholar


  •  Received: 30 September 2023
  •  Accepted: 08 November 2023
  •  Published: 30 November 2023

References

Amlogu A, Mainaji T, Sundus W, Charles T, Ihab (2016). 'A comparative study: long and short term effect of a nutrition-sensitive approach to delay the progression of HIV to AIDS among people living with HIV (PLWH) in Nigeria', Functional Foods in Health Disease 6(2):79-90. 
Crossref

 

Anywar GK, Esezah B, Robert M, Jackson SA, Oryem-Origa H (2020). 'Medicinal plants used by traditional medicine practitioners to boost the immune system in people living with HIV/AIDS in Uganda'. European Journal of Integrative Medicine 35:101011. 
Crossref

 

Aprioku J, Sydney R, Ohanado O, Atuboyedia W, Tamuno I (2022). 'Moringa supplementation improves immunological indices and hematological abnormalities in seropositive patients receiving HAARTs'. African Health Sciences 22(2):1-11. 
Crossref

 

Bauer G (2021). 'The potential significance of high avidity immunoglobulin G (IgG) for protective immunity towards SARS-CoV-2'. International Journal of infectious diseases 106:61-64.
Crossref

 

Dang L, Vu Phuong P, Viet Hung N, Duc Minh D, Thanh Thi N, Thu Hoai Le, Thanh Hai N, Van Lam Vu, Thi P (2018). 'Elevation of immunoglobulin levels is associated with treatment failure in HIV-infected children in Vietnam'. HIV/AIDS-Research Care, Palliative pp. 1-7. 
Crossref

 

Dimitrov JD, Lacroix-Desmazes, SK, Srinivas V (2011) 'Important parameters for evaluation of antibody avidity by immunosorbent assay'. Analytical Biochemistry 418(1):149-151. 
Crossref

 

Ekiert H?, Joanna K, Pawe? R, Agnieszka S, Agnieszka (2021). 'Artemisia annua-importance in traditional medicine and current state of knowledge on the chemistry, biological activity and possible applications'. Planta Medica 87(8):584-599. 
Crossref

 

French MA, Tjiam M, Christian A, Laila NF, Sonia J (2017). Frontiers in immunology 'Antiviral functions of human immunodeficiency virus type 1 (HIV-1)-specific IgG antibodies: effects of antiretroviral therapy and implications for therapeutic HIV-1 vaccine design'. Frontiers in immunology 8:780.
Crossref

 

Gambo AM, Indres B, Musa B, Tesleem K, Gqaleni N (2021). 'A double-blind, randomized controlled trial to examine the effect of Moringa oleifera leaf powder supplementation on the immune status and anthropometric parameters of adult HIV patients on antiretroviral therapy in a resource-limited setting'. PloS one 16(12):e0261935. 
Crossref

 

Gambo A, Gqaleni N, Babalola, T (2022). 'Does Moringa oleifera Lam. leaves supplementation have an impact on the weight and bone mass index of people living with HIV that are on antiretroviral therapy? A double-blind randomized control trial'. PloS one 13(3). 
Crossref

 

Ghraichy M, Galson JD, Kovaltsuk A, Von Niederhäusern V, Pachlopnik S, Jana R, Mike J, Annaïse JM, Enkelejda K, Dominic FD, Charlotte M (2020). 'Maturation of the human immunoglobulin heavy chain repertoire with age'. Frontiers in immunology 11:1734. 
Crossref

 

Gouda NK (2023). 'Living with Reduced HIV/AIDS Stigma and Discrimination: A Migrants-Theoretical Scheme BT - Sustainable Health Through Food, Nutrition, and Lifestyle', in A. Grover, A. Singh, and R.B. Singh (eds). Singapore: Springer Nature Singapore pp. 289-306.
Crossref

 

Gunda D, Kilonzo W, Semvua B, Kamugisha E, Rauya E, Mpondo Z, Bonaventura C (2017). 'Prevalence and risk factors of poor immune recovery among adult HIV patients attending care and treatment center in northwestern Tanzania following the use of highly active antiretroviral therapy: a retrospective study'. BMC Research Notes 10(1):1-6. 
Crossref

 

Hou L, Huang H (2016). 'Immune suppressive properties of artemisinin family drugs'. Pharmacology & therapeutics 166:123-127. 
Crossref

 

Kamphorst AO, Ahmed R (2013). 'CD4 T-cell immunotherapy for chronic viral infections and cancer'. Immunotherapy 5(9):975-987. 
Crossref

 

Kankara S, Sani N, Abubakar I, Bindawa KA, Haruna M, Rabi'u B, Abubakar A, Ibrahim B (2022). 'Indigenous traditional knowledge of medicinal plants used for the management of HIV/AIDS opportunistic infections in Katsina State, Nigeria'. Ethnobotany Research Applications 23:1-17. 
Crossref

 

Kardava L, Moir S (2019). 'B-cell abnormalities in HIV-1 infection: roles for IgG3 and T-bet'. Current Opinion in HIV AIDS 14(4):240. 
Crossref

 

Kimuda S, Biraro G, Irene AB, Bernard SR, John G, Cose S (2018). 'Characterising antibody avidity in individuals of varied Mycobacterium tuberculosis infection status using surface plasmon resonance', PLoS One, 13(10):e0205102. 
Crossref

 

Liu H, Tian X, Zhang Y, Wang C, Jiang H (2013). 'The discovery of Artemisia annua L. in the Shengjindian cemetery, Xinjiang, China and its implications for early uses of traditional Chinese herbal medicine qinghao.'. Journal of ethnopharmacology 146(1):278-286. 
Crossref

 

Liu J, Wang L, Hou Y, Zhao Y, Dou Z, Ma Y, Zhang D, Wu Y, Zhao D, Liu Z (2020). 'Immune restoration in HIV-1-infected patients after 12 years of antiretroviral therapy: a real-world observational study'. Emerging Microbes Infections 9(1):2550-2561. 
Crossref

 

Lubbe A, Seibert I, Klimkait T, van der K, Frank (2012). 'Ethnopharmacology in overdrive: The remarkable anti-HIV activity of Artemisia annua'. Journal of Ethnopharmacology 141(3):854-859. 
Crossref

 

Lubinga, S J Kintu, A Atuhaire, J Asiimwe S (2012). 'Concomitant herbal medicine and Antiretroviral Therapy (ART) use among HIV patients in Western Uganda: a cross-sectional analysis of magnitude and patterns of use, associated factors and impact on ART adherence'. AIDS care 24(11):1375-1383. 
Crossref

 

Lugada ES, Mermin J, Asjo B, Kaharuza F, Downing R, Langeland N, Ormaasen V, Bruun J, Awor AC, Ulvestad E (2004). 'Immunoglobulin levels amongst persons with and without human immunodeficiency virus type 1 infection in Uganda and Norway'. Scandinavian journal of immunology 59(2):203-208. 
Crossref

 

Mendicino CC, Moodie EE, Guimarães MD, Pádua CA (2021). 'Immune recovery after antiretroviral therapy initiation: a challenge for people living with HIV in Brazil'. Cadernos de Saúde Pública 37:e00143520. 
Crossref

 

Mirbehbahani FS, Hejazi F, Najmoddin N, Asefnejad A (2020). 'Artemisia annua L. as a promising medicinal plant for powerful wound healing applications.'. Progress in biomaterials 9(3):139-151.
Crossref

 

Molari M, Eyer K, Baudry J, Cocco S, Monasson R (2020). 'Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers'. Elife 9:e55678. 
Crossref

 

Monera-Penduka T, Maponga G, Charles C, Wolfe A, Wiesner R, Lubbe M, Gene D, Nhachi CFB (2017). 'Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study'. AIDS research therapy 14:1-7. 
Crossref

 

Mugo C, Shkedy W, Ziv M, Samuel A, Tadesse B, Roel W, Dolphine M, Christina S (2022). 'Modelling trends of CD4 counts for patients on antiretroviral therapy (ART): a comprehensive health care clinic in Nairobi, Kenya'. BMC infectious diseases 22(1):29. 
Crossref

 

Nair N, Moss WJ, Scott S, Mugala N, Ndhlovu ZM, Lilo K, Ryon JJ, Monze M, Quinn TC, Cousens S, Cutts F (2009). 'HIV-1 infection in Zambian children impairs the development and avidity maturation of measles virus-specific immunoglobulin G after vaccination and infection'. The Journal of infectious diseases 200(7):1031-1038. 
Crossref

 

Negin J, Gregson S, Eaton JW, Schur N, Takaruza A, Mason P, Nyamukapa C (2016). 'Rising levels of HIV infection in older adults in Eastern Zimbabwe'. PloS one 11(11):e0162967. 
Crossref

 

Ogwang P, Ogwal E, Jasper O, Kasasa S, Ejobi F, Kabasa D, Obua C (2011). 'Use of Artemisia annua L. infusion for malaria prevention: mode of action and benefits in a Ugandan community'. British Journal of Pharmaceutical Research 1(4):124-132. 
Crossref

 

Onifade AA Ojerinde AO Emeka GJ Oluogun WA (2017). 'The role of IgG, IgA and IgM as immunological markers of HIV/AIDS progression'. Journal of AIDS and HIV Research 9(7):152-158. 
Crossref

 

Song A, Li Z, Luo Z, Lu X, Wang R, Liu L, Xia W, Wan Z, Zhang T, Su B, Jiang W (2020). 'Effects of early and delayed antiretroviral therapy on plasma anti-CD4 autoreactive IgG and its association with CD4+ T-cell recovery in acute HIV-infected individuals'. Frontiers in Pharmacology 11:449. 
Crossref

 

Tomaras G, Yates D, Nicole L, Liu P, Qin L, Fouda G, Chavez G, Leslie L Decamp, Allan C Parks, Robert J Ashley, Vicki C Lucas, Judith T (2008). 'Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia'. Journal of virology 82(24):12449-12463. 
Crossref

 

Voltersvik P, Albrektsen G, Ulvestad E, Dyrhol-Riise A, Sørensen B, Åsjö B (2003). 'Changes in immunoglobulin isotypes and immunoglobulin G (IgG) subclasses during highly active antiretroviral therapy: anti-p24 IgG1 closely parallels the biphasic decline in plasma viremia'. JAIDS Journal of Acquired Immune Deficiency Syndromes 34(4):358-367.
Crossref