African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2286

Full Length Research Paper

Ginkgo bilobaL.: Phytochemical components and antioxidant activity

Bárbara Luisa Fermino
  • Bárbara Luisa Fermino
  • Pharmacy Department, Central West State University, UNICENTRO, Guarapuava, PR, Brazil.
  • Google Scholar
Michele Caroline Milanez
  • Michele Caroline Milanez
  • Pharmacy Department, Central West State University, UNICENTRO, Guarapuava, PR, Brazil.
  • Google Scholar
Guilherme Barroso Langoni de Freitas
  • Guilherme Barroso Langoni de Freitas
  • Pharmacy Department, Central West State University, UNICENTRO, Guarapuava, PR, Brazil.
  • Google Scholar
Weber Cláudio Francisco Nunes da Silva
  • Weber Cláudio Francisco Nunes da Silva
  • Pharmacy Department, Central West State University, UNICENTRO, Guarapuava, PR, Brazil.
  • Google Scholar
Romaiana Picada Pereira
  • Romaiana Picada Pereira
  • Chemistry Department, Ponta Grossa State University , UEPG, Ponta Grossa, PR, Brazil.
  • Google Scholar
João Batista Teixeira da Rocha
  • João Batista Teixeira da Rocha
  • Chemistry Department, Federal University of Santa Maria, UFSM, Santa Maria, RS, Brazil.
  • Google Scholar
Juliana Sartori Bonini*
  • Juliana Sartori Bonini*
  • Pharmacy Department, Central West State University, UNICENTRO, Guarapuava, PR, Brazil.
  • Google Scholar


  •  Received: 28 May 2015
  •  Accepted: 13 August 2015
  •  Published: 15 October 2015

References

Ahlemeyer B, Kriegelsteins J (1998). Neuroprotective effects of Ginkgo biloba extract. In: Lawson L, Bauer R. (Ed). Phytomedicines of Eurose chemistry and biological activity.Washington. Am. Chem. Soc. 210-220.
Crossref
 
Albuquerque UP, Hanazaki N (2006). As pesquisas etnodirigidas na descoberta de novos fármacos de interesse médico e farmacêutico: fragilidades e perspectivas. Revista Bras. Farmacogn. (16):678-689
 
Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M (2014). Herbal antioxidant in clinical practice: A review. Asian Pac. J. Trop. Biomed. 4(1):78-84.
Crossref
 
Almeida ER (2009). Plantas adaptógenas e com ação no sistema nervoso central. São Paulo: Biblioteca 24 horas.
 
Amri H, Ogwuegbu SO, Boujrad N, Drieu K, Papadopoulos V (1996). In vivo regulation of peripheral-type benzodiazepine receptor and glucocorticoid synthesis by Ginkgo biloba extract EGb 761 and isolated ginkgolides. Endocrinology 137(12):5707-5718.
 
Apetz N, Munch G, Govindaraghavan S, Gyengesi E (2014). Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease—a translational perspective. CNS Neurol. Disord. Drug Targets 13(7):1175-91.
Crossref
 
Banov D, Baby AR, Del Bosco LM, Kaneko TM, Velasco MVR (2006). Caracterização do Extrato Seco de GinkgobilobaL. em Formulações de uso tópico. Acta Farmacêutica Bonaerense 25(2):219-224.
 
Barbosa LF, Medeiros MHG, Augusto O (2006). Danos oxidativos e Neurodegeneração: o que aprendemos com animais transgênicos e nocautes? Química Nova 29(6):1352-1360.
Crossref
 
Beek TAV (2000). Ginkgo biloba: medicinal and aromatic plants. Amsterdam: Taylor & Francis e-Library pp. 475-490.
 
Berigan TR, Page BW (2000). A ginkgo biloba – Associated Paranoid reaction. Prim. Care Companion J. Clin. Psychiatry 2(50):183.
Crossref
 
Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (1998). The Complete German Commission e Monographs: therapeutic guide to herbal medicines.Austin: American Botanical Council p 684.
 
Blumenthal M (2000). Herbal medicine: expanded commission e monographs.Newton: Integrative Medicine Communication/American Botanical Council p 519.
 
Boligon AA, Freitas RB, Brum TF, Piana M, Belke BV, Rocha JBT, Athayde ML (2013). Phytochemical constituents and in vitro antioxidant capacity of Tabernaemontanacatharinensis. Free Radic. Antioxid. 3(2):77-80.
Crossref
 
Bridi R, Steffen VM, Henriques AT (2001). Investigação da atividade antioxidade do extrato padronizado de Ginkgobiloba (EGb 761) em ratos. Revista Brasileira de Ciências Farmacêuticas 37(2):159-164.
 
Castro AP, Mello FB, Mello JRB (2005). Avaliação toxicológica do Ginkgobiloba sobre a fertilidade e reprodução de ratos Wistar. Acta Sci. Vet. 33(3):265-269.
 
Chen CC, Chiang AN, Liu HN, Chang YT (2014). EGb-761 prevents ultraviolet B-induced photoaging via inactivation of mitogen-activated protein kinases and proinflammatory cytokine expression. J. Dermatol. Sci. 75(1):55-62.
Crossref
 
Chen X, Hong Y, Zheng P (2015). Efficacy and safety of extract of Ginkgo biloba as an adjunct therapy in chronic schizophrenia: A systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. Psychiatry Res. 228(1):121-127.
Crossref
 
Czelusniak KE, Brocco A, Pereira DF, Freitas GBL (2012). Farmacobotânica, fitoquímica e farmacologia do Guaco: revisão considerando MikaniaglomerataSprengel e Mikanialaevigata Schulyz Bip. ex Baker. Rev. Bras. Plantas Med. 14(2):400-409.
Crossref
 
D'ippolito JAC, Rocha LM, Silva RF (2005). Fitoterapia magistral: um guia prático para a manipulação de fitoterápicos. São Paulo: AnfarmagElbergráfica.
 
Defeudis FV (1991). Ginkgo Biloba Extract (EGb 761): Pharmacological Activities and Clinical Applications.Paris: Elsevir.
 
Diamond BJ, Shiflett SC, Feiwel N, Matheis RJ, Noskin O, Richards JÁ, Schoenberger NE (2000). Ginkgo biloba extract: mechanisms and clinical indications. Arch. Phys. Med. Rehabil. 81(5):668-678.
Crossref
 
Ekor M (2014). The growing use of herbal medicines: Issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Neurology, 4 JAN, art. no. Article 177.
Crossref
 
Forlenza OV (2003). Ginkgobiloba e memória: mito ou realidade? Revista de Psiquiatria Clínica 30(6):218-220.
Crossref
 
Gauthier S, Schlaefke S (2014). Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: A systematic review and meta-analysis of randomized placebo-controlled trials. Clin. Interv. Aging 9:2065-2077.
Crossref
 
Colombo (2011). Responsável técnico Anny M. Trentini. Colombo: Botânico Ltda. Bula de medicamento. Disponível em: http://www.herbarium.net/geral/bulas/GinkgoBula_17984_0111_00005.pdf .
 
He J, Lin J, Li J, Zhang JH, Sun XM, Zeng CM (2008). Dual effects of Ginkgo biloba leaf extract on human red blood cells. Nordic Pharmacol. Soc. 104:138-144.
 
He YT, Xing SS, Gao L, Wang J, Xing QC, Zhang W (2014). Ginkgo biloba attenuates oxidative DNA damage of human umbilical vein endothelial cells induced by intermittent high glucose. Pharmazie 69(3):203-207.
 
Hirata BK, Banin RM, Dornellas AP, de Andrade IS, Zemdegs JC, Caperuto LC, Oyama LM, Ribeiro EB, Telles MM (2015). Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats. Mediators Inflamm. 2015:419106.
Crossref
 
Ilhan A, Gurel A, Armutcu F, Kamisli A, Iraz M, Akyol O, Ozen A (2004). Ginkgo biloba prevents mobile phone-induced oxidative stress in rat brain.Clin. Chim. Acta (340):153-162.
Crossref
 
Imai H, Nakagawa Y (2006) Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic. Biol. Med. 34:145-169.
Crossref
 
Jager LS, Perfetti GA, Diachenko GW (2006). Analysis of ginkgolides and bilobalide in food products using LC-APCI-MS. J. Pharm. Biomed. Anal. 41:1552-1559.
Crossref
 
Kock E (2005). Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. Phytomedicine 12:10-16.
Crossref
 
Kose K, Dogan P, Ascioglu M, Ascioglu O (1997). In vitro antioxidant effect of Ginkgo biloba extract (EGb 761) on lippoperoxidation induced by hydrogen peroxide in erythrocytes of Behcet's patients. Jap. J. Pharmacol. 75:253-258.
Crossref
 
Kusmic C, Basta G, Lazzerini G, Vesentini N, Barsacchi R (2004). The effect of Ginkgo biloba in isolated ischemic/reperfused rat heart: a link between vitamin E preservation and prostaglandin biosynthesis. J. Cardiovas. Pharmacol. 44:356-362.
Crossref
 
Lima JP, David JM (2006). Plantas medicinais. Fármacos derivados de plantas. Apud: Silva, P. Farmacologia. 7.ed. Rio de Janeiro: Guanabara Koogan 148-159.
 
Lorenzi H, Matos FJA (2000). Plantas Medicinais no Brasil: nativas e exóticas.Nova Odessa: Instituto Plantarum de Estudos da Flora Ltda.
 
Lorenzi H, Souza HM, Torres MAV, Bacher LB (2003). Árvores exóticas no Brasil: madeireiras, ornamentais e aromáticas.Nova Odessa: Instituto Plantarum de Estudos da Flora Ltda.
 
Luo Y (2001). Ginkgo biloba neuroprotection: therapeutic implications in Alzheimer's disease. J. Alzheimers Dis. 3(4):401-407.
 
Macarenco RSS, Takahagi RU, Bardella LC (2001). Estudo da ação do extrato de Ginkgobilobae amido hidroxietílico hipertônico na atenuação de alterações decorrentes de isquemia e reperfusão de órgãos esplâncnicos em ratos. Acta Cirúrgica Brasileira 16(3):139-145.
Crossref
 
Mckenna DJ, Jones K, Hugues K (2001). Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. Altern. Ther. Health Med. 7(5):70-90.
 
Mills S, Bone K (2000). Principals and practice of phytotherapy: modern herbal medicine.Londres: Churchill Livingstone.
 
Montes P, Ruiz-Sánchez E, Rojas C, Rojas P (2015). Ginkgo biloba extract 761: A review of basic studies and potential clinical use in psychiatric disorders CNS Neurol. Disord. Drug Targets 14(1):132-149.
Crossref
 
Pereira RP, Boligon AA, Appel AS, Fachinetto R, Ceron CS, Tanus-Santos JE, Athayde ML, Rocha JBT (2014). Chemical composition, antioxidant and anticholinesterase activity of Melissa officinalis. Ind. Crops Prod. 53:34-45.
Crossref
 
Puppo E, Silva CP (2008). Levantamento do perfil medicamentoso e freqüência de associações entre o Ginkgo (Ginkgobiloba L.) e ácido acetilsalicílico, em usuários atendidos pela Farma USCS de São Caetano do Sul. Revista de Ciências Farmacêuticas Básica e Aplicada 29(1):53-58.
 
Raven PH, Evert RF, Eichhorn SE (2001). Biologia vegetal. Rio de Janeiro: Guanabara Koogan.
 
Rover LJ, Hoehr NF, Vellasco AP (2001). Sistema antioxidante envolvendo o ciclo metabólico da glutationa associado a métodos eletroanalíticos na avaliação do estresse oxidativo. Revista Química Nova 24(1):112-119.
 
Sarikcioglu S, Oner G, Tercan E (2004). Antioxidant effect of EGb 761 on hydrogen peroxide-induced lipoperoxidation of G-6-PD deficient erythrocytes. Phytother. Res. 18:837-840.
Crossref
 
Siegel G, Ermilov E, Knes O, Rodríguez M (2014). Combined lowering of low grade systemic inflammation and insulin resistance in metabolic syndrome patients treated with Ginkgo biloba. Atherosclerosis 237(2):584-588.
Crossref
 
Schneider CM, Pereira JMP, Morais LO, Silva AG (2007). O extrato de folhas e sementes do ginkgo, Ginkgobiloba L. (Ginkgoaceae) no tratamento e profilaxia das isquemias. Natureza online 5(2):90-95.
 
Schulz V, Hansel R, Tyler VE (2002). Fitoterapia racional: um guia de fitoterapia para as ciências da saúde.Barueri: Manole.
 
Silva RR, Oliveira TT, Nagem TJ, Leão MA (2002). Efeito de flavonoides no metabolismo do ácido araquidônico. Rev. Med. 35:127-133.
Crossref
 
Silva TFO, Marcelino CE, Gomes AJPS (2010). Utilizações e interações medicamentosas de produtos contendo o Ginkgobiloba.Colloquium Vitae 2(1):54-61.
Crossref
 
Smith JV, Luo Y (2004). Studies on molecular mechanisms of Ginkgo biloba extract. Appl. Microbiol. Biotechnol. 64:465-472.
Crossref
 
Solfrizzi V, Panza F (2015). Plant-based nutraceutical interventions against cognitive impairment and dementia: Meta-analytic evidence of efficacy of a standardized Gingko biloba extract. J. Alzheimers Dis. 43(2):605-611.
 
Spadiene A, Savickiene N, Skesters A, Silova A, Rodovicius H (2012). The effects of Ginkgo biloba L. and Camellia sinensis L. extracts on oxidative stress in patients with type 2 diabetes. Afr. J. Pharm. Pharmacol. 6(44):3080-3085.
Crossref
 
Tisato V, Zauli G, Rimondi E, Gianesini S, Brunelli L, Menegatti E, Zamboni P, Secchiero P (2013). Inhibitory effect of natural anti-inflammatory compounds on cytokines released by chronic venous disease patient-derived endothelial cells. Mediators Inflamm. 2013: 423407.
Crossref
 
Vasconcelos SML, Goulart MOF, Moura JBF, Manfredini V, Benfato MS, Kubota LT (2007). Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação. Química Nova 30:1323-1338.
Crossref
 
Xie H, Wang J-R, Yau L-F, Liu Y, Liu L, Han Q-B, Zhao Z, Jiang Z-H (2014). Catechins and procyanidins of ginkgo biloba show potent activities towards the inhibition of β-amyloid peptide aggregation and destabilization of preformed fibrils. Molecules 19(4):5119-5134.
Crossref
 
Wang S, Wang D, Liu Z (2015). Synergistic, additive and antagonistic effects of Potentilla fruticosa combined with EGb761 on antioxidant capacities and the possible mechanism. Ind. Crops Prod. 67:227-238.
Crossref
 
Wu W, Zhu X (1999). Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extracts against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice. Life Sci. 65:157-164.
Crossref
 
Yang M, Xu DD, Zhang Y, Liu X, Hoeven R, Cho WCS (2014). A systematic review on natural medicines for the prevention and treatment of Alzheimer's disease with meta-analyses of intervention effect of ginkgo. Am. J. Chin. Med. 42(3):505-521.
Crossref
 
Yoshikawa T, Naito T, Kondo M (1999). Ginkgo biloba leaf extract: review of biological actions and clinical applications. Antioxid. Redox Signal. 1(4):469-480.
Crossref
 
Zhao Q, Gao C, Cui Z (2015). Ginkgolide A reduces inflammatory response in high-glucose-stimulated human umbilical vein endothelial cells through STAT3-mediated pathway. Int. Immunopharmacol. 25(2):242-248.
Crossref