African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 15 April, 2013; 7(14)

April 2013

Evaluation of cytotoxic properties of Curcuma longa and Tagetes erecta on cancer cell line (Hep2)

Cancer is the major public difficulty and one of the top causes of death in prosperous countries. Conventional plants are precious source of novel cytotoxic agents and play a critical role in health concern. Due to its wide range of biological and pharmacological effects and lack of toxicity, curcumin and lutein were selected for this study. Curcumin and lutein were isolated from rhizomes of Curcuma...

Author(s): Niraikulam Ayyadurai+, Natarajan Valarmathy+, S. Kannan, D. Jansirani and Abdulrahman Alsenaidy

April 2013

Pentoxifylline inhibits intimal hyperplasia and vascular smooth muscle cell proliferation in a rabbit carotid artery anastomosis model

This study aimed to evaluate the inhibitory effect of pentoxifylline, a phosphodiesterase inhibitor on intimal hyperplasia (IH) and vascular smooth muscle cell proliferation in an anastomosis model of rabbit carotid artery (CA). Right CAs of 18 male New Zealand white rabbits were anastomosed under general anesthesia. After the surgical procedure, 18 rabbits were separated into three study groups, 6 in each. Group 1...

Author(s): Ali Aycan Kavala, Koray Aykut, Emrah Sisli,Yusuf Kuserli, Bekir Ugur Ergur, Eyup Hazan and Gokhan Albayrak

April 2013

Resveratrol inhibits rat pulmonary fibroblast proliferation through modulation of TLR4/NF-κB pathway

Resveratrol shows a powerful therapeutic effect in several cardiovascular diseases and cancer. Recent studies suggest a protective role of resveratrol in pulmonary fibrosis, but the underlying mechanism remains unknown. The aim of the present study is to investigate the anti-inflammatory effect of resveratrol on pulmonary fibrosis and reveal the role of toll like receptor 4 (TLR4) signaling pathway during the...

Author(s): Li Zhen-yu#, Yi Jun#, Wang Qian, Yang Tian-lun, Pu Xiao-qun and Li Chuan-chang

April 2013

Elderly drug utilization in the community assessed through pharmacy dispensing data

People of 65 years and above now comprise a greater share of the world's population than ever before, and this proportion will increase during the 21st century. In Spain, between 55 and 90% of the elderly consume a drug. This study characterizes the use of drugs by elderly through dispensing data at the community pharmacy.  This study was conducted at a community pharmacy in Madrid, Spain in 2011. A...

Author(s): Alina Martinez Sanchez

April 2013

Repaglinide as a safe alternative against hypoglycemia in fasting elderly diabetic patients: A single blinded, placebo-controlled, six period, cross-over study

Elderly are more prone to develop hypoglycemia or miss meals. Repaglinide and nateglinide are suggested to have glucose-dependent insulinotropic effect. The aim of the present work was to test the effect of both drugs on serum glucose and insulin levels in fasting elderly diabetic patients. Eight elderly diabetics underwent a fixed dose single blinded, placebo controlled, six period, cross-over study at the Department...

Author(s): Hussam A.S. Murad, May Hamza and Sarah A. Hamza