April 2013
Evaluation of cytotoxic properties of Curcuma longa and Tagetes erecta on cancer cell line (Hep2)
Cancer is the major public difficulty and one of the top causes of death in prosperous countries. Conventional plants are precious source of novel cytotoxic agents and play a critical role in health concern. Due to its wide range of biological and pharmacological effects and lack of toxicity, curcumin and lutein were selected for this study. Curcumin and lutein were isolated from rhizomes of Curcuma...
April 2013
Pentoxifylline inhibits intimal hyperplasia and vascular smooth muscle cell proliferation in a rabbit carotid artery anastomosis model
This study aimed to evaluate the inhibitory effect of pentoxifylline, a phosphodiesterase inhibitor on intimal hyperplasia (IH) and vascular smooth muscle cell proliferation in an anastomosis model of rabbit carotid artery (CA). Right CAs of 18 male New Zealand white rabbits were anastomosed under general anesthesia. After the surgical procedure, 18 rabbits were separated into three study groups, 6 in each. Group 1...
April 2013
Resveratrol inhibits rat pulmonary fibroblast proliferation through modulation of TLR4/NF-κB pathway
Resveratrol shows a powerful therapeutic effect in several cardiovascular diseases and cancer. Recent studies suggest a protective role of resveratrol in pulmonary fibrosis, but the underlying mechanism remains unknown. The aim of the present study is to investigate the anti-inflammatory effect of resveratrol on pulmonary fibrosis and reveal the role of toll like receptor 4 (TLR4) signaling pathway during the...
April 2013
Elderly drug utilization in the community assessed through pharmacy dispensing data
People of 65 years and above now comprise a greater share of the world's population than ever before, and this proportion will increase during the 21st century. In Spain, between 55 and 90% of the elderly consume a drug. This study characterizes the use of drugs by elderly through dispensing data at the community pharmacy. This study was conducted at a community pharmacy in Madrid, Spain in 2011. A...
April 2013
Repaglinide as a safe alternative against hypoglycemia in fasting elderly diabetic patients: A single blinded, placebo-controlled, six period, cross-over study
Elderly are more prone to develop hypoglycemia or miss meals. Repaglinide and nateglinide are suggested to have glucose-dependent insulinotropic effect. The aim of the present work was to test the effect of both drugs on serum glucose and insulin levels in fasting elderly diabetic patients. Eight elderly diabetics underwent a fixed dose single blinded, placebo controlled, six period, cross-over study at the Department...
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