African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2205

Table of Content: 15 August, 2016; 10(30)

August 2016

Peptide hydroxamate derivatives as regulators for insulin receptor signaling and its degradation by zinc metalloprotease in diabetic rats

Insulin-degrading enzyme (IDE) is the major zinc-metalloprotease involved in the cleavage of insulin, β-amyloid protein and mainly contributes to the pathophysiology of type 2 diabetes and Alzheimer’s disease. Therefore, this enzyme is expressed as candidate target for drugs used in the management of diabetes and peptide hydroxamates have been reported recently as inhibitors for IDE. Novel synthesized peptide...

Author(s): Mohamed Mahmoud Elseweidy, Rawia Sarhan Amin, Hebatallah Husseini Atteia, Maha Abdo Ali, Nader E. Abo-Dya and Khaled A. Agha

August 2016

GC-MS analysis of esterified fatty acids obtained from leaves and seeds of Triplaris gardneriana Wedd.

Triplaris gardneriana Wedd. belongs to the family Polygonaceae. In Brazil, the plant is known as "Pajéu". The plant has a traditional use in folk medicine for the treatment of some human diseases. In this study, it was realized for first time, the extraction and characterization by gas chromatography–mass spectrometry (GC-MS) of the fixed oils from the leaves and seeds of T. gardneriana collected...

Author(s): Sandra Kelle Souza Macêdo, Anderson Lucas de Lavor, Naiane Darklei dos Santos Silva, Tamires dos Santos Almeida, Iza Miranda Melo Paulo, Georgia Sueley Bezerra, Flávia Keile Souza Macedo, Victor Hugo Almeida dos Anjos, José Alves de Siqueira Filho, Jackson Roberto Guedes da Silva Almeida and Xirley Pereira Nunes

August 2016

Phytochemical and pharmacological screenings of organic crude fractions of Maesa acuminata

The present study is aimed to investigate phytochemical and pharmacological activities of crude organic fractional extracts of Maesa acuminata (MA). Preliminary test for phytoconstituents shows the presence of alkaloid, glycoside, steroids, tannins, saponins and reducing sugars. Fractionation was done by ethanol (leaf: ELMA), chloroform (bark: CBMA) and n-hexane (leaf: HLMA). The crude fractions were then subjected for...

Author(s): Thoufiqul Alam Riaz, Mohammed Ibrahim, Jannatul Ferdous, Md. Torequl Islam,, Atiqur Rahaman, Effat Ara Naznin, Nasreen Sultana, Márcia Fernanda Correia Jardim Paz, Marcus Vinicius Oliveira Barros de Alencar, João Marcelo de Castro e Sousa, Sandra Maria Mendes de Moura Dantas, and Ana Amélia de Carvalho Melo-Cavalcante,