December 2013
A preliminary attempt to address indomethacin’s poor water solubility using solid self emulsifying drug delivery system as a carrier
The non-steroidal anti-inflammatory drug (NSAID), indomethacin, is disadvantaged by its poor water solubility and gastrointestinal adverse effects. The aim of this work therefore was to formulate this drug into solid self emulsifying drug delivery system (SSEDDS) as an attempt to improve its aqueous solubility and anti-inflammatory property using shea butter or its blend with Bos indicus lipid. Proximate analysis was...
December 2013
Traditional resources evaluation of district Shangla, Pakistan
Study on traditional resources evaluation was carried out during summer 2008 in various parts of district Shangla. The potential for sustainable livelihood development in the region was assessed by analysing the forest dwellers' livelihood assets and perceptions of the forest livelihood. The study also explores the uses of forest resources and the methodology is largely based on the sustainable livelihood framework....
December 2013
A novel gastroretentive floating system for zidovudine, based on calcium-silicate beads
The aim of the research effort entertained herein was to develop, evaluate and fully characterize a multiparticulate floating gastroretentive system for the modified release of zidovudine (AZT), an antiretroviral drug. AZT was used as a water-soluble model drug at therapeutic doses. The floating gastroretentive system was obtained via polymer coating of calcium silicate-adsorbed AZT. The proposed system was evaluated in...
December 2013
Effect of lutein in development of experimental diabetic nephropathy in rats
The present study has been designed to investigate the effect of lutein in streptzotocin induced diabetic nephropathy in Wistar rats. Diabetic nephropathy (DN) was induced by administering single dose of streptozotocin in Wistar rats. DN was clinically assessed by the estimation of various biochemical parameters and histopathological studies of renal tissue. Diabetic nephropathy was assessed biochemically by blood urea...
December 2013
Role of serotonergic and dopaminergic neurotransmission in the antidepressant effects of malt extract
The benefit of malt extract in clonidine-induced depression was previously reported. The present study aimed to explore its mechanism of action. Animals were classified into normal and depressed rats. Induction of depression was done by i.p. injection of clonidine (0.8 mg/kg) daily for 7 days. Depressed rats were sub-classified into 6 groups treated for one week as follows: Group I received 1% tween 80 p.o. (control...
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