July 2013
Controlled release colon targeted drug delivery systems of non-steroidal anti-inflammatory drug, indomethacin
This study aimed to investigate the efficacy of both xanthan gum (XG) and guar gum (GG) controlling the release rate of the poorly water soluble drug, indomethacin (IDM) from colon target drug delivery systems. Binary mixtures of the drug and the hydrophilic carrier (XG) in the ratios of 1:1 and 1:2 and tertiary mixture in the ratio of 1:1:1 IDM: XG: GG were prepared using three different approaches namely, physical...
July 2013
Comprehensive study of the intestinal absorption of four phenolic compounds after oral administration of Ananas comosus leaf extract in vivo and in vitro
The extract of Ananas comosus leaf (EAL) was proved to be antihyperlipidemia and antihyperglycemia consisting of rich phenolic acids. Pharmacokinetic study showed p-coumaric acid was a rich compound detected in the mouse plasma after EAL oral administration. The aim of this study was to explore the alteration of the absorption of four principle phenolic compounds through the intestines by oral administration....
July 2013
Ciprofloxacin inhibits proliferation and synergistic effect against hepatocellular carcinoma cancer lines with cisplatin
Combination therapy has generated significant interest in the clinical setting since it increases the therapeutic potential of anticancer drugs. The potential therapeutic benefits in combination of cisplatin and ciprofloxacin have not been fully explored in hepatocellular carcinoma cancer therapy. In the results to be presented here, cellular viability of Hep G2 and Bel-7402 was determined by the 3-(4,...
July 2013
Evaluating the anti-fertility activity of Talinum paniculatum (Jacq.) Gaertn in female wistar rats
Talinum paniculatum (Jacq.) Gaertn (T. paniculatum) root and leaf methanolic extracts exhibited significant estrogenic activity in female Wistar rats. Both extracts (100 and 1,000 mg.kg-1 B.W) produced anti-immplantation activity and early abortifacient activity in a dose dependent manner (P<0.001). The phytochemical screening of the plant extracts showed presence of various phytosterols: campesterol,...
July 2013
Antidiabetic activity of seed extracts of Caesalpinia crista Linn. in experimental animals
The present study was designed to evaluate antidiabetic activity of ethanolic and aqueous seed extracts of Caesalpinia crista linn. in streptozotocin (STZ) induced diabetes in 2 days old pups models. The seeds were collected, authenticated and shade dried. Shade dried seeds were then grinded into coarse powder and processed for further studies. Ethanolic and aqueous extracts were prepared and the preliminary...
July 2013
Pharmaceutical analysis of Euphorbia cyparissias included on Beta-cyclodextrin complexes
The methods of bio-control have diversified resulting in study of new fighting measures. Studies on Euphorbia cyparissias active compounds as well as their in vivo and in vitroactivity revealed a significant pharmacologic activity, encouraging design of a complex original conditioning. Encapsulation techniques can be of considerable help in this endeavour, being a means to protect...
July 2013
Effect of cholic acid on colonic motility in mice
The role of bile acids on the gastrointestinal motility are contradictory, especially the role of mast cells mediators in this effect. Thus, cholic acid (CA) was examined for its in vitro action on the motility of the mice colon using different doses of CA (0.3, 30, 50, 100, 200, 300 and 500 µM). The contractile activity of the colon segment was recorded as changes in intraluminal pressure under...
July 2013
Potential antioxidant and anti-inflammatory effects of Hyphaena thebaica in experimentally induced inflammatory bowel disease
Ulcerative colitis and Crohn’s disease are chronic recurrent inflammatory bowel disease (IBD) of unknown origin. Oxidative stress is believed to be a key factor in the pathogenesis of the mucosal damage in IBD. The aqueous extract of Hyphaena thebaica fruits showed an antioxidant activity; this is due to the substantial amount of their water-soluble phenolic contents. This study was undertaken to study...
July 2013
The efficacy of premedication with ibuprofen, gelofen and acetaminophen in the depth of anesthesia in mandibular molars with irreversible pulpitis
Pain control is one of the major aspects in dental practice. Dental pain can usually be controlled using different techniques such as local anesthesia and medications. Acetaminophen is a pain reliever and fever reducer. However, it shows no effect on inflammation. Therefore, non-steroidal anti-inflammatory drugs are currently used to control inflammation and pain. This study sought to compare the efficacy of...
July 2013
Effects of forsythoside on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages
Forsythoside (FS) is an active component of Forsythia suspense and exhibit a certain functions, such as, anti-inflammation, anti-bacterial, anti-virus, among others. However, immunomodulation effects of FS at cell level have been unclear. This work is to investigate the effects of FS on RAW264.7 cells stimulated with lipopolysaccharide (LPS) by detecting the release of cytokines and chemokines,...
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