March 2013
Antioxidant compounds, assays of determination and mode of action
The human body uses an antioxidant defense system to neutralize the excessive levels of reactive oxygen species. This system consists of enzymatic and non enzymatic antioxidants,catalase, peroxidase, superoxide dismutase and gluatathion s-transferease as major defense enzymes. However, ascorbic acid, tocopherol, and phenolic compounds are considered as examples for non-enzymatic antioxidants. Increasing research on...
March 2013
Safety and efficiency of valsartan and combination of valsartan plus hydrochlorothiazide for high blood pressure
The essential hypertension is one of the most common cardiovascular risk factors in adult population. The duration of hypertension influences the risk of stroke, heart failure, atherosclerosis, and kidney disease. Diuretics, beta blockers, calcium-antagonists, ACE-inhibitors, and sartans may be used to treat arterial hypertension. In this study, the efficacy and safety of a prompt pharmacologic treatment with...
March 2013
Determination of levo-tetrahydropalmatine in rat plasma by HPLC and its application to pharmacokinetics studies
The objective of this study was to establish a high performance liquid chromatography (HPLC) method for the determination of levo-tetrahydropalmatine (l-THP) in rat plasma, and to investigate the pharmacokinetics after oral administration of l-THP in rats. The plasma samples were extracted by ethyl acetate. The mobile phase consisted of a mixture of phosphoric acid (0.1%) and methanol (60: 40 v/v)....
March 2013
Penta-O-galloyl-beta-D-glucose enhances antitumor activity of imatinib and suppresses the growth of K562 cells in mice
This study involves the antitumor potential of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) to induce apoptosis and enhance antitumor activity of imatinib in K562 cells. Though PGG was reported to have antitumor activities in breast, prostate, kidney, liver cancers and HL-60 leukemia cells, there is no report on synergistic antitumor effect of PGG with imatinib until now. In the present study, PGG significantly...
March 2013
Pharmacokinetics of piperine following single dose administration of benjakul formulation in healthy Thai subjects
Benjakul formulation is a Thai traditional medicine preparation, has also been used as an adaptogenic drug for cancer patients. No toxicity, either acutely or chronically has been reported in experimental animals and humans. The study was to preliminarily investigate the pharmacokinetics of piperine, the major active component of Benjakul formulation, following the administration of single oral doses of 100 (group 1)...
March 2013
PAMAM dendrimers affect the in vitro release of clotrimazole from hydrogels irrespective of its molecular state
Insufficient aqueous solubility of clotrimazole (CLO) is the main problem in designing pharmaceutical formulations and limits its therapeutic efficiency. Polyamidoamine (PAMAM) dendrimers give the opportunity to decrease this limitation because of their solubilising and permeation enhancement properties. The aim of this study was to examine the influence of PAMAM dendrimers on the release of CLO from hydrogels and water...
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