Insufficient aqueous solubility of clotrimazole (CLO) is the main problem in designing pharmaceutical formulations and limits its therapeutic efficiency. Polyamidoamine (PAMAM) dendrimers give the opportunity to decrease this limitation because of their solubilising and permeation enhancement properties. The aim of this study was to examine the influence of PAMAM dendrimers on the release of CLO from hydrogels and water suspensions. PAMAM dendrimers improved permeation of CLO from all analyzed formulations in the following order: PAMAM-NH2 G3 > PAMAM-NH2 G2 > PAMAM-OH G3 > PAMAM-OH G2. The effect evoked by PAMAM dendrimers was the most potent from hydrogels containing dissolved drug.
Key words: Polyamidoamine (PAMAM) dendrimers, clotrimazole, hydrogels.
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