April 2016
Influence of polymorphism of adenosine triphosphate binding cassette on oral drug absorption
Administration of drugs via oral route is the most common and convenient. Three major factors can affect drug absorption from this route: physiologic, physicochemical and formulation. Drug absorption mainly takes place in small intestine after oral administration. Within the small intestine, there are 2 major families of proteins involved in transport that have significant roles on drugs absorption:...
April 2016
Antioxidant and antinociceptive effect of the hydroethanolic extract and fractions of the bark of Bowdichia virgilioides in orofacial pain
Bowdichia virgilioides is used by the population for treating inflammation in general. This study evaluated the antinociceptive activity and possible mechanisms of action of hydroethanolic extract (HEE) and hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fraction of HEE obtained from the plant stem bark against orofacial pain, as well as in vitro its antioxidant effect on the scavenging of...
April 2016
Phytochemistry and antibacterial activity of extracts from medicinal plant Olea africana
Increase in prevalence of resistant microorganisms especially to synthetic drugs, has necessitated the need to search for new bioactive compounds having natural origin. Phytochemical investigation of Olea africana extracts afforded two triterpenoids namely erythrodiol and uvaol which were obtained through repeated column chromatography. The compounds were characterized using Nuclear Magnetic Resonance (NMR) spectroscopy...
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