African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2205

Table of Content: 22 April 2016; 10(15)

April 2016

Influence of polymorphism of adenosine triphosphate binding cassette on oral drug absorption

Administration of drugs via oral route is the most common and convenient. Three major factors can affect drug absorption from this route: physiologic, physicochemical and formulation. Drug absorption mainly takes place in small intestine after oral administration. Within the small intestine, there are 2 major families of proteins involved in transport that have significant roles on drugs absorption:...

Author(s): Muluemebet Fikadu and Tesfaye Gabriel

April 2016

Antioxidant and antinociceptive effect of the hydroethanolic extract and fractions of the bark of Bowdichia virgilioides in orofacial pain

Bowdichia virgilioides is used by the population for treating inflammation in general. This study evaluated the antinociceptive activity and possible mechanisms of action of hydroethanolic extract (HEE) and hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fraction of HEE obtained from the plant stem bark against orofacial pain, as well as in vitro its antioxidant effect on the scavenging of...

Author(s): Andrea Yu Kwan Villar Shan, Elis Cristiane Valença de Almeida, André Luiz Lima Menezes dos Santos, Amanda do Carmo Bion de Lima, Clisiane Carla de Souza Santos, Marília Trindade de Santana Souza, Nicole Prata Damascena, Silvan Silva de Araújo, Jymmys Lopes dos Santos, Monica Silveira Paixão, Anderson Carlos Marçal, Lucindo José Quintans Júnior, Brancilene Santos de Araujo and Charles dos Santos Estevam

April 2016

Phytochemistry and antibacterial activity of extracts from medicinal plant Olea africana

Increase in prevalence of resistant microorganisms especially to synthetic drugs, has necessitated the need to search for new bioactive compounds having natural origin. Phytochemical investigation of Olea africana extracts afforded two triterpenoids namely erythrodiol and uvaol which were obtained through repeated column chromatography. The compounds were characterized using Nuclear Magnetic Resonance (NMR) spectroscopy...

Author(s): Kemboi Douglas, Joyce Jepkorir Kiplimo and Denis Chirchir