August 2012
Phytochemistry and pharmacologic properties of Ziziphus spina christi (L.) Willd.
Ziziphus spina-christi known as Christ's Thorn Jujube, is a native plant that grows in tropical and subtropical regions especially in Middle East. Its extracts are important in drug development with pharmacological activities in the Middle East and South and East of Asia including Iran. For a long time, Z. spina-christi has been used in alternative medicine for the treatment of fever, pain, dandruff,...
August 2012
Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L.
Coriandrum sativum L. commonly known as “Coriander” is an annual herb, indicated for a number of medical properties in traditional medicine. For a long time, C. sativum has been used in traditional medicines as an anti-inflammatory, analgesic, and antibacterial agent. Its essential oil is also used as a natural fragrance with some medicinal properties. C. sativum has recently been...
August 2012
Berberis lycium Royle: A review of its traditional uses, phytochemistry and pharmacology
Berberis lycium Royle (family: Berberidaceae), a native to Pakistan, India and whole region to Himalyas is widely used like food and in folk medicine. A wide range of medicinally and nutritionally important phytochemical constituents have been isolated from plant such as alkaloids, cardioactive glycosides, saponins, tannins, anthocyanins, vitamins, carbohydrates, proteins, lipids, fiber content, β...
August 2012
The protective effect of Acanthopanax senticosus B on apoptosis in rat adrenal pheochromocytoma cell line (PC12) cell induced by sodium cyanide (NaCN)/glucose deprivation
The protective effect of Acanthopanax senticosus B (ASB) on apoptosis in Rat adrenal pheochromocytoma cell line (PC12) cell induced by sodium cyanide (NaCN)/glucose deprivation was studied. The PC12 cell was cultured in RPMI-1640 medium supplemented with 10% newborn calf serum at 37°C in a 5% CO2 incubator. NaCN/glucose deprivation was conducted to establish an oxidative-stress injury...
August 2012
Effect of the type of disintegrant on the characteristics of orally disintegrating tablets manufactured using new ready-to-use excipients (Ludiflash® or Parteck®) by direct compression method
The challenge in orally disintegrating tablets (ODTs) production encompasses the compromise between instantaneous disintegration and sufficient physico-mechanical properties, therefore the aim of this study was to evaluate the influence of selected disintegrants on the characteristics of ODTs manufactured using novel ready-to-use excipients (Ludiflash® or Parteck®) by direct compression method. Effect of...
August 2012
Pharmacokinetics of vitexin in rats after intravenous and oral administration
Vitexin was isolated from the leaves of Crataegus pinnatifida Bge. var major, and its pharmacokinetics and bioavailability were carried out via validated high-performance liquid chromatography (HPLC) method using hesperidin as internal standard in healthy rats after intravenous and oral administration at a dose of 10 mg/kg and 30 mg/kg, respectively. The pharmacokinetic parameters were...
August 2012
The role of two natural flavonoids on human amylin aggregation
Misfolded amylin, the human polypeptide hormone, forms amyloid deposits in pancreatic islets. These amyloid deposits contribute to the dysfunction of beta-cells and the loss of beta-cell mass in type 2 diabetes mellitus (T2DM). Inhibition of amylin fibrillization has been regarded as a potential therapeutic approach for T2DM. Using fluorescence spectroscopic analysis with thioflavin T, the role of two naturally...
August 2012
Cardioprotective effects of aerobic regular exercise against doxorubicin-induced oxidative stress in rat
Doxorubicin (DOX) is an anthracycline antibiotic that is widely used as an anticancer agent. However, the clinical use of DOX is limited due to its cardiotoxic side effects. Few studies have assessed pretreatment effects of chronically exercise against doxorubicin-induced cardiotoxicity. The aim of this study was to determine cardioprotective effects of aerobic regular exercise against doxorubicin-induced oxidative...
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