August 2016

Assessment of the anti-allergenic effects of Scoparia dulcis in asthma management

Anti-allergics, including mast cell stabilizers, are used together with other anti-inflammatory drugs in the management of asthma, so as to prevent the release of pre-formed inflammatory mediators upon allergen exposure. This study was aimed at investigating the mast cell stabilizing and anti-anaphylactic effects of a 70% hydro-ethanolic extract of Scoparia dulcis (SDE) in murine models upon exposure to a known...

Author(s): Jones Ofori-Amoah, George Asumeng Koffuor, Emmanuel Akomanin Asiamah, Hope Yao Agbemenyah and Albert Kumi Awuku

August 2016

Toxicogenetic and antioxidant activities of isopentyl ferulate

This study aims to determine the toxicity, genotoxicity and antioxidative defense capacities of isopentanyl ferulate (IF), an ester derivative of ferulic acid (FA). Therefore, albino mice (25-30 g) were treated with 1000 to 3000 mg/kg orally (p.o.) and intraperitoneally (i.p.) to determine median lethal dose (LD50), biochemical and hematological parameters, motor coordination and genotoxic activity by comet assay. In...

Author(s): Marcela Rosado Drumond Taimo, Adailson Almeida Araruna Júnior, Antonio Luiz Gomes Júnior,, Ana Maria Oliveira Ferreira da Mata, Marcus Vinícius Oliveira Barros de Alencar,, Md. Torequl Islam,, Márcia Fernanda Correia Jardim Paz, Hercília Maria Lins Rolim, Maria das Graças Freire de Medeiros, Ana Amélia de Carvalho Melo-Cavalcante,