August 2018

Study on increasing the solubility and dissolution rate of sulfamethoxazole by cyclodextrins

The aim of this study was to enhance the solubility and dissolution rate of sulfamethoxazole (SMZ) by preparing the inclusion complexes with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HPβ-CD) and γ-cyclodextrin (γ-CD). The effect of the type of cyclodextrins used for the preparation of complexes, on the in vitro dissolution profiles and solubilities in different mediums (pH 4.5...

Author(s): Jülide Åžahin and Nurten Özdemir  

August 2018

Extrapyramidal and purgative effects of fluphenazine in turkeys

Fluphenazine is a typical antipsychotic medicine with extrapyramidal effects. It was tested for purgative and neurological effects in turkeys. The results showed that the drug induced purgation at a dose range of 5 to 200 mg/kg body weight causing highest frequency of fecal droppings (7) at 10 mg/kg in 7 min and lowest frequency of dropping (1) at 50 mg/kg. However, the number of fecal droppings was not linearly...

Author(s): Saganuwan Alhaji Saganuwan  

August 2018

Anti-ulcer and hematological properties of virgin coconut oil (VCO) against indomethacin-induced gastric ulcer in experimental rats

Previous studies have reported various health benefits of virgin coconut oil (VCO) such as weight management, treatment of burns, infections, improve phagocytic activity, etc. The present study was conducted to investigate the anti-ulcer and hematological properties of VCO against indomethacin-induced gastric ulcers using rat model. Twenty-four Wistar albino rats were used for the study and were divided into 6 groups of...

Author(s): Joshua Onyeagoziri Okafor, Parker Elijah Joshua and Chimere Young Ukegbu