December 2013
Parasite control practices and anthelmintic efficacy field study on gastrointestinal nematode infections of Horro sheep in Western Oromiya, Ethiopia
Gastrointestinal nematodes are one of the rampant parasitic diseases constraining sheep farming in western Oromiya. A study aimed at assessing parasite control practices in use and to determine the efficacy of three brands of anthelmintics commonly used on the farms was conducted. Questionnaire survey and faecal egg count reduction tests (FECRT) were used to collect data. Majority of respondents (95.3%) indicated that...
December 2013
Effect of an anorexiant on levels of 5-HIAA and GSH in brain of well-nourished and malnourished rats
In this study, the effect of sibutramine and carnitine on 5-HIAA and GSH levels in brain regions of malnourished rats was analyzed. Twenty-four rats were fed with a normal protein diet (23%) and another similar group with protein starvation diet (7%). The animals of both groups were re-assigned into four groups of 6 animals per group and treated for 10 days as follows: group 1, saline solution; group 2, sibutramine (10...
December 2013
Preparation, characterization, in vitro and in vivo evaluation of PEGylated-mucin matrix tablets containing aqueous leaf extract of Vernonia amygdalina
The objectives of this research were to formulate and evaluate PEGylated mucin matrix tablets containing Vernonia amygdalina leaf water extract. PEGylated mucin matrices formulated with PEG 8000 and mucin from the African land snail Archachatina marginata at ratios 1:1, 0:1, 1:0, 3:1 and 1:3 were used to prepare V. amygdalina tablets by dry granulation and direct compression. Characterization based on surface...
December 2013
Sub-chronic treatment of calcineurin inhibitor averts impairment of cognitive function in animal model of amnesia
Although the actions of tacrolimus-calcineurin inhibitor on cognitive function have been studied; its impact on scopolamine-induced memory impairment has not been explored. Therefore, this study examined the effects of one-week tacrolimus treatment on memory deficit caused by scopolamine, which is an established pharmacological model of Alzheimer's disease induction. The evaluation of hippocampus-dependent learning...
December 2013
Effect of lutein in development of experimental diabetic nephropathy in rats
The present study has been designed to investigate the effect of lutein in streptzotocin induced diabetic nephropathy (DN) in wistar rats. Diabetic nephropathy was induced by administering single dose of streptozotocin in wistar rats. DN was clinically assessed by the estimation of various biochemical parameters and histopathological studies of renal tissue. Diabetic nephropathy was assessed biochemically by blood urea...
December 2013
Synergic effects of some medicinal plants on anti-oxidant status and lipid peroxidation in diabetic rats
The leaves of Psidium guajava, Anacardium occidentale, Eucalyptus globulus and fruits of Xylopia aethiopica are used in the management of diabetes mellitus. Hence, the phytochemical constituents as well as the acute toxicity of the combined chloroform extracts (A. occidentale + E. globulus and P. guajava + X. aethiopica) and their effects (at graded doses of 100 and 250 mg/kg body weight each) on the concentration of...
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