African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2145

Table of Content: 22 February, 2012; 6(7)

October 2013

Effect of iron on the proliferation of lung adenocarcinoma cells in vitro

To investigate the effect of iron on the cell proliferation of lung adenocarcinoma cell, A549 cells were respectively treated with chloride ferric (FeCl3) and/or deferoxamine (DFO) at different concentrations, the viable cell number and cell viability were analyzed in each group at 6, 12, 24 and 48 h, respectively. After A549 cells were respectively treated with FeCl3 at different concentrations, the viable cell...

Author(s): Zhe Cheng, Yongna Song, Jie Xia, Yan Kang, Ling-ling Dai and Yufeng Liu

October 2013

Transcription factors and target genes relationship based method reveals potential thermal injury related genes

Thermal injury to the skin can induce local and systemic perturbations that are costly in terms of human suffering as well as in strains on the health care system. We used the GSE8056 microarray data to identify potential genes related to burn wound to construct a regulation network. In the network, some of transcription factors (TFs) and target genes have been proved that are related to burn wound in previous study. We...

Author(s): Bo Li, Yuxin Song, Hui Zhang and Wenyuan Luo

October 2013

An in vivo study on the diuretic activity of Holarrhena antidysenterica

Holarrhena antidysenterica is used as diuretic in traditional medicine. The aim of this study was to evaluate the crude extract of H. antidysentrica seeds (Ha.Cr) and its fractions, n-hexane (Ha.Hx), n-butanol (Ha.Bu) and aqueous (Ha.Aq), for their diuretic effect in Wistar rats and to investigate whether the activity is concentrated in any of the fractions. Wistar rats kept on fasting for 24 h with...

Author(s): Aslam Khan, Samra Bashir and Anwarul-Hassan Gilani

October 2013

Protective effect of Naoshuning in a rat brain ischemia-reperfusion damage model

To evaluate the protective effects of Naoshuning Chinese traditional medicine on the brain ischemia-reperfusion (IR) injury in rats and explore the possible mechanism of IR injury, rats were divided into 4 groups: sham-operation group, model group as negative control group, Naoshuning group as treatment group and ginaton group as positive control group. The brain IR model was established in rats. Reperfusion was carried...

Author(s): Mei-kui Zhang, Shao-qing Shen, Feng-hua Xu, Ruo-zhuo Liu and Ting-ting Chen

October 2013

Curative effects by different chemotherapeutic measures pertaining to Methotrexate on unruptured ectopic pregnancy

The aim of this study was to investigate curative effects by different chemotherapeutic measures involving the use of Methotrexate (MTX) on unruptured ectopic pregnancy. Between January 2001 and April 2004, a total of 164 patients with unruptured ectopic pregnancy were treated. They were randomly divided into four groups. In Group I, 50 mg/m2 of MTX was administered 3 times every...

Author(s): Ying-Lan Liu, Ya-Ling Zhang and Jian-Hua Fu

October 2013

Screening of antiproliferative effect of Limonia acidissima Linn. fruit extracts on human breast cancer cell lines

The aim of the study is to evaluate the anticancer effect of Limonia acidissima Linn. (Family Rutaceae) which has long been prescribed for various infectious and malignant diseases. The fruit extract of L. acidissima Linn. has been carried out by following due procedure. Cell lines, cultures were incorporated and procured for in-vitro and in-vivo study with reference to cell...

Author(s): D. Pradhan, G. Tripathy and S. Patnaik

October 2013

Effect of Xingnaojing on somatostain and arginine vasopressin in rats with vascular dementia

To explore the effect of Xingnaojing on the somatostain and arginine vasopressin in a rat vascular dementia model, a total of 24 male Sprague-Dawley rats were randomly divided into three groups: sham group (S), vascular dementia group (VD) and Xingnaojing group (XNJ). The memory was measured by Morris water maze test before operation and before and after Xingnaojing treatment. Treatment was performed for 15 days, and...

Author(s): Xujuan Li, Mincong Zhou, Yufeng Li, Wangli Huang, Deqiang Li, Jinfeng Duan and Wei Cai

October 2013

Effects of Citrus aurantium extract on spermatogenic cell density, antioxidant activity and testosterone level in male mice

The aim of this study was to investigate the effects of Citrus aurantium extract on sperm characteristics, spermatogenic cell density, antioxidant activity and testosterone level of male mice. Twenty-eight adult male Balb/C mice were divided into four groups; each having seven mice. Two milliliter distilled water, C. aurantium extract with low concentration (0.01 mg/kg), medium concentration (0.02...

Author(s): Shahrzad Khakpour, Marzieh Minaee, Simin Fazelipour and Shahram Zarrabian

October 2013

Bevacizumab in combination with taxotere, carboplatin and herceptin (TCH) chemotherapy for targeted therapy of advanced-stage breast cancer: A case study

A 45-year-old woman visited our department due to enlargement and ulceration of the right breast. Core needle biopsy and pathological examination revealed invasive ductal carcinoma of right breast (grade II). Immunohistochemistry showed that tissues were negative for estrogen receptor (ER) and progesterone receptor (PR), but positive for epidermal growth factor receptor-2 (Her-2) (+++) and vascular endothelial...

Author(s): Min Wang, Xianmin Wang, Weicai Chen, Huisheng Wu, Zun Wang and Jinsong He

October 2013

Design and evaluation of thiolated chitosan based mucoadhesive and permeation enhancing bilayered buccal drug delivery system

The objective of this study was to increase the bioavailability of fluvastatin by developing bilayered buccal mucoadhesive compacts. This study also focuses on the mucoadhesive potential of some natural gums for improved mucoadhesion and transmucosal permeation of existing mucoadhesive polymers by certain modifications. Bilayered mucoadhesive compacts with one layer of drug and mucoadhesive polymer, and second, non...

Author(s): H. Shah Viral, Shelat Pragna and B. Shah Gaurang

October 2013

Investigation of the pharmacokinetics of a novel sustained release metformin hydrochloride suspension with ion exchange resin as carriers in beagle dogs

A novel metformin hydrochloride sustained-release suspension containing ion exchange resin as carriers have been reported in a previous study. In the present study, the pharmacokinetics of this sustained-release suspension in beagle dogs was investigated. A high performance liquid chromatography (HPLC) method was established to detect the amount of metformin hydrochloride in vivo. The pharmacokinetics parameters of...

Author(s): Hongfei Liu, Shuang Shuang Shi, Changshan Sun, Xin Zhao, Sheng Shen and Hao He