January 2016

Preparation of sertraline-loaded chitosan nanoparticles and the pharmacokinetics studies

Sertraline is a worldwide used antidepressant for perinatal depression. However, the secreting of sertraline into milk arose the concerns for the potentially negative effects on breastfed infants. The present study aims to alter the biodistribution of sertraline by loading the drug into chitosan-nanoparticles. Our results demonstrated an effective way to load the water-soluble sertraline into nanoparticles, and keep the...

Author(s): Tian-Yuan Zhang, Dan-Qing Chen, Jian-Qing Gao, and Yu-Lan Hu,

January 2016

Prophylactic administration of a Propionibacterium acnes-killed preparation increases survival in animals with polymicrobial sepsis via the nitric oxide and TNF-α pathway

Propionibacterium acnes (P. acnes) is a gram-positive anaerobic microorganism present in human skin, and has being widely used in clinical trials as a suitable candidate for therapeutic approach to sepsis. A previous study performed by our research group demonstrated that a P. acne killed preparation had an important immunomodulatory role in severe sepsis. Hence, this study we evaluated the...

Author(s): Temístocles I´talo de Santana, Jaciana dos Santos Aguiar, Larissa Cardoso Corrêa de Araújo, Sandrine Maria de Arruda Lima, Bruno Iraquitan Miranda da Silva, Fabiana Oliveira dos Santos Gomes, Christina Alves Peixoto, Paloma Lys de Medeiros and Teresinha Gonçalves da Silva