July 2012
Effects of diabetes mellitus and postmenopausal period on the lungs of rats
The aim of this study was to determine the effects of diabetes mellitus, ovarian aging, ovarian aging plus diabetes mellitus, and the oxidative stress generated by these conditions on the lungs of rats, using histopathological and biochemical parameters. In the diabetic group, some abnormalities like bronchial hyperplasia, edema, haemorrhage, pulmonary capillary dilatation, breakdown of alveoli, mononuclear...
July 2012
Depo-Provera and depression In Iranian women
Depression in women can cause crucial physical, psychological and social reactions. Different studies showed controversial effects of Depo-Provera on incidence and intensifying depression or else wise not being effective on the mood. A total of 64 women aged 18 to 45 participated in a 12 weeks Depo-Provera injection intervention. Assessments were made before and 12 weeks after Depo-Provera...
July 2012
Simple and rapid ultra high performance liquid chromatographic (UHPLC) method for the determination of levetiracetam in human serum: Application to a bioequivalence study
A rapid and valid method is reported for the determination of levetiracetam (LEV) in human plasma with ultra high performance liquid chromatography (UHPLC) and ultraviolet (UV) detection. To 100 µl serum 50 µl lamivudine (IS, 10 µg/ml) was added as an internal standard and the mixture subjected to liquid extraction using 1 ml ethylacetate. A mixture of acetonitril and distilled water (80:20) was used...
July 2012
Using carbetocin to prevent hemorrhage in laparoscopic myomectomy
The objective of this study was to evaluate the clinical effect and safety of carbetocin administered to prevent bleeding in laparoscopic myomectomy. A retrospective analysis of April, 2006 to April, 2011 laparoscopic myomectomy hand clinical data of 70 patients was carried out. The 70 patients were divided into treatment group and control group; the treatment group was given preoperative carbetocin, while the control...
July 2012
Mucopolysaccharidosis type I: Homology modeling and docking analysis of the lysosomal enzyme, human α-L-iduronidase
Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder caused due to the deficiency of lysosomal human α-L-iduronidase (IDUA) that catalyzes degradation of glycoaminoglycans, heparan and dermatan sulfate. MPS I patients manifest a wide spectrum of clinical phenotypes, ranging from mild to severe debilitating forms. Due to the absence of three dimensional (3-D) structure of IDUA, structural-functional...
July 2012
Novel controlled release oxypentifylline microspheres; Preparation, characterization and in-vivo evaluation
The aim of this work was to formulate and evaluate controlled-release oxypentifylline (OXP) microspheres that fulfill the requirements for extended release medications using Ammonio Methacrylate Copolymer RS100 as polymeric material. The microspheres were prepared by quasi-emulsion solvent diffusion technique. The effect of process variables such as a drug to polymer ratio, stirring rate, and concentration of emulsifier...
July 2012
Effect of valsartan on action potential and potassium efflux in rabbits with myocardial infarction
The aim of this study was to characterize the effects of valsartan on ventricular tachycardia or fibrillation (VT/VF) after myocardial infarction (MI). Rabbits in the MI and valsartan (VAL) groups were subjected to median sternotomy followed by left coronary artery ligation. MI was induced among the rabbits and the VAL rabbits were given VAL orally for 12 weeks. VT/VF episodes, as well as monophasic action potentials...
July 2012
Compatibility and stability of lornoxicam with morphine, tramadol or fentanyl in infusion solutions
The administration of drugs via patient controlled intravenous analgesia (PCIA) is routinely practiced for the management of postoperative pain. A combination of lornoxicam and opioid analgesics such as morphine, tramadol, or fentanyl is often administered for the management of severe pain to ensure that a minimal dose of each is used. Unfortunately, no data are available about compatibility and stability of lornoxicam...
July 2012
Computer-aided learning for medical chart review instructions
The purpose of this study was to develop computer-aided learning (CAL) of medical chart review instructions for pharmacy students and to study the efficiency and effectiveness of the CAL. The participants were forty-eight 5th year pharmacy students at Faculty of Pharmacy, Ubon Ratchathani University, Thailand. They were divided into two groups by simple random sampling: an experimental group (n = 22) that studied...
July 2012
Drug/xenobiotic metabolizing enzyme polymorphisms in a Turkish population
Genetic polymorphisms of drug/xenobiotic metabolizing enzymes can have great impact on the inter-individual variation in drug response or susceptibility to toxicities of xenobiotics. The frequencies of the polymorphic enzymes not also differ from ethnicity, but also differ from country to country in the same ethnic group. In this study, CYP2E1*5B, GSTM1, GSTT1,GSTP1 exon 5 and GSTP1 exon 6...
July 2012
Optimization of ultrasonic extraction process based on central composite design-response surface methodology for luteolin in Taraxacum officinale
Ultrasonic extraction (UE) was performed to extract luteolin from Taraxacum officinale. This procedure resulted in high extraction yield. The content of luteolin was determined by reverse phase-high performance liquid chromatography (RP-HPLC). The UE process of luteolin fromT. officinale was optimized by using central composite design-response surface methodology (CCD-RSM). The results showed that the optimal...
July 2012
Subacute toxicity of piperonyl butoxide and resmethrin in mice
The subacute toxic effects of separate and combined use of piperonyl butoxide and resmethrin (cismethrin) on the liver and kidneys of male mice were investigated. It is known that when given alone, pyrethroids are toxic and their toxicity becomes more complicated when they are co-formulated with piperonyl butoxide. In the present study, macroscopic and microscopic changes were determined in the liver and kidney tissues....
July 2012
Liposome-loaded pingyangmycin: A new possible agent to treat hemangioma
Infantile hemangioma is a tumor of the microvasculature composed predominantly of proliferating endothelial cells. Pingyangmycin (bleomycin A5), a water-soluble glycopeptide produced by Streptomyces pingyangensisn, has been used as a sclerosing agent for the treatment of hemangioma. However, its utility is limited by adverse side effects, including significant pain, swelling, pulmonary fibrosis and life-threatening...
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