June 2012
In vitro evaluation of the influence of compounds with tricyclic structure on the microbial growth and expression of virulence factors
The purpose of this study was to evaluate the in vitro antimicrobial activity of some newly synthesized oxepins and to investigate their influence on the expression of virulence factors of Gram-negative (Escherichia coli, Proteus vulgaris, Morganella morganii, Salmonella arizonae,Klebsiella planticola, and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus)...
June 2012
Evaluation of CD4+ and CD8+ T-lymphocyte counts and serum levels of immunoglobulins in pulmonary tuberculosis (PTB) patients with or without HIV co-infection in South Eastern Nigeri
The prevalence and incidence of tuberculosis (TB) has risen throughout sub-Saharan Africa with increasing human immuno-deficiency virus (HIV) prevalence. TB patients were recruited from some treatment centres in South Eastern Nigeria, and a total number of 133 subjects were recruited for the study. The following parameters, namely, CD4+ and CD8+ T-cell counts, immunoglobulin A (IgA), immunoglobulin G...
June 2012
Design and characterization of ofloxacin mucoadhesive in situ hydrogel
The aim of the study is to design, optimize and characterize an ophthalmic in situ gelling system of an antibacterial agent, ofloxacin using polyacrylic acid (PAA) as the gelling agent along with Noveon® AA-1 USP Polycarbophil as a viscosity enhancer. A 32 full factorial design was applied for the optimization of the final formulation. The effect of independent variables was evaluated...
June 2012
Multi-drug resistance, verotoxin production and efficacy of crude stem bark extracts of Curtisia dentata among Escherichia coli (non-O157) and Acinetobacter species isolates obtained from water and wastewater samples
Drug resistant diarrhea and nosocomial infections caused by verotoxic Escherichia coli and some Acinetobacter species has posed serious therapeutic challenges, especially in developing countries. The aim of this work is to investigate multi-drug resistance, verotoxin-production and susceptibility of E. coli and Acinetobacter spp. isolated from some water samples to crude stem bark...
June 2012
Efficacy of piroxicam on acute pain induced by full thickness excision wounds in rats
The present study assessed the pain threshold, behavioural changes and metabolic stress response associated with full thickness excision wounds in rats. Also, the analgesic efficacy and side effects of piroxicam used in the alleviation of pain post wound infliction were evaluated. The results of the study showed that full thickness excision wound induced acute pain which lasted up to 72 h. Rats showed decreased...
June 2012
A comparative study of the fracture strength of dental porcelains: Vita VMK 95 versus Noritake
One fundamental dimension of long-lasting dental treatments which has attracted many researchers is the fracture strength of dental porcelains. To contribute to this aspect of research, we have compared the fracture strength of two types of porcelains in metal-ceramic restorations: Vita VMK 95 and Noritake. To carry out this research, a standard die made of stainless steel was prepared. Then molds were prepared...
June 2012
Evaluation of analgesic and anti-inflammatory effects of fresh onion juice in experimental animals
Onion is a well known traditional medicinal plant that has been consumed for its putative nutritional and health benefits for centuries. This study was carried out to determine the possible analgesic and anti-inflammatory effects of fresh onion juice in experimental animals. Hot plate and formalin tests were used to study the analgesic effect of fresh onion juice in mice during acute and chronic pain stages modeling,...
June 2012
Evaluation of base for optimal drug delivery for iontophoretic therapy: Investigation of quality and stability
Increasing the penetration rates of active substances from transdermal preparations to skin is a major goal for the pharmacy technologists. Higher concentration of the active substance in the skin is commonly associated with higher treatment quality. The aim of this study was to model an optimal pharmaceutical iontophoretic delivery form and to examine the dependency of its quality and stability on different parameters...
June 2012
Pharmacological beneficial effect and side effect of intrathecal analgesia, prospective, randomized control trial
Spinal anesthesia is sufficient to provide adequate motor blockage and also provides effective pain relief during the initial post-operatives period. In order to maximize post-operative analgesia, a number of adjutants have been added to local spinal anesthetics. The objective of this study is to compare the beneficial and side effects of intrathecal midazolam and ketamine in patients undergoing lower limb surgery. This...
June 2012
N-acetylaspartylglutamate (NAAG) exhibits anti-inflammatory effects on carrageenan-induced paw edema model of inflammation in rats
The present study was designed to evaluate anti-inflammatory effects of N-acetylaspartylglutamate (NAAG), as a presynaptic mGlu3 receptor agonist on carrageenan-induced paw edema in rats. NAAG was administered intraperitoneally (10 mg/kg) 20 min before the intraplantar injection of the carrageenan. Neutrophil infiltration (MPO activity), lipid peroxidation (MDA assay), free radical scavenging activity (SOD and GPx...
June 2012
Progesterone versus magnesium sulfate in the management of preterm labour
Preterm labour is the leading cause of prenatal and neonatal mortality morbidity and long term neurodevelopmental problems. Diverse treatments have been employed in past to suppress preterm labour. Magnesium sulfate is often used as first line in suppression of preterm labour. Side effect of this includes thirst, hyperthermia, headache, diplopia, respiratory depression and rare cases respiratory paralysis and arrest. We...
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