June 2019

Sex differences in the neuroprotective effect of insulin against chemically-induced convulsions in mice

Insulin, an important regulator of peripheral metabolism, has been reported to interact with many neurotransmitter systems including those associated with convulsion. The effect of insulin against pentylenetetrazole and strychnine-induced convulsions in mice, as well as possible sex differences, were evaluated in this study. Mice of both sexes weighing between 20 and 25 g were administered insulin intraperitoneally at...

Author(s): Susanna Adeola Adebayo, Oluwole Isaac Adeyemi, Adegbenga Rotimi Owolabi and Moses Atanda Akanmu

June 2019

Effect of amodiaquine on the pharmacokinetics of gliclazide in diabetic subjects

The study aims at investigating the effect of amodiaquine on the pharmacokinetic profile of gliclazide. It is a one-way single dose cross-over study in two phases. Six freshly diagnosed diabetic volunteers were used. The subjects acted as their own control, and each phase was preceded by an overnight fast. Phase 1 of the study involved the administration of a single oral dose of 80 mg of gliclazide after an overnight...

Author(s): Sambo Godwin Ishaku, Mojirade Taibat Bakare-Odunola, Aminu Musa, Ibrahim Adamu Yakasai, Magaji Garba and Bulus Adzu