March 2013
Pharmacokinetics of 600 mg loading dose of clopidogrel in patients undergoing percutaneous coronary intervention
Clopidogrel is an oral antiplatelet drug. Loading dose of 600 mg clopidogrel was shown to improve clinical outcome in patients following percutaneous coronary intervention (PCI). Wide inter-individual variation has been detected in clopidogrel response that can be related to variation in Clopidogrel serum concentration. The aim of this study was to assess the pharmacokinetics parameters of 600 mg loading dose...
March 2013
Pharmacological evaluation, molecular docking and dynamics simulation studies of salicyl alcohol nitrogen containing derivatives
The current study was conducted to evaluate in vivo the anti-inflammatory, antinociceptive and antipyretic activities of salicyl alcohol nitrogen containing derivatives that are [4-(2-hydroxybenzyl) morpholin-4-iumchloride (I)], [1,4-bis (2-hydroxybenzyl) piperazine-1,4-diium chloride (II)]. The synthetic compound I, II and standard (aspirin) were evaluated in thelaboratory animal model at three different...
March 2013
Sunitinib enhanced the effect of combretastatin A-4 by inducing apoptosis in vitro
Sunitinib is an inhibitor of angiogenesis, and CA-4 is being studied in clinical trials as a vascular disrupting agent. Various combinations involving an anti-angiogenic agent and an anti-vascular agent could cause much more effective anti-tumor responses. The present study indicated that the combination of an anti-angiogenic agent (sunitinib) and an anti-vascular agent (CA-4) exerted synergistic anti-proliferative...
March 2013
Influence of different doses of Iopromide on renal function of elderly patients
This study aims to investigate influences of different doses of hypisotonic non-ionic contrast agent (Iopromide) on renal function of elderly patients. A total of 30 cases of elderly patients without a history of nephrosis and with normal renal function were divided into two groups according to the different doses of received contrast agent. Influences of Iopromide on renal function were observed by detecting blood urea...
March 2013
Investigation of antioxidant, cytotoxic and apoptotic activities of the extracts from tubers of Asphodelus aestivus Brot.
In this study, potential antioxidant activities of crude extracts from Asphodelus aestivus Brot. (AA) tubers were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay, and cytotoxic and apoptotic activity of the extracts on MCF-7 breast cancer cells were evaluated by trypan blue exclusion assay, comet assay and hoechst 33258/propidium iodide double staining. Crude diethyl ether and ethyl...
March 2013
Anticonvulsant effect of Indigofera suffruticosa Mill: Indication of involvement of the GABAergic system
This objective of this study was to evaluation of the anticonvulsant effect of Indigofera suffruticosa through the methanol extract of its leaves. Swiss albino mice were subjected to dosages of 100 and 300 mg/kg methanol extract for the study of the anticonvulsant action; the following convulsants were used: pentylenetetrazole (100 mg/kg), picrotoxin (10 mg/kg), strychnine (2 mg/kg), and pilocarpine (600 mg/kg). In the...
March 2013
Expression of tyrosine hydroxylase and growth-associated protein 43 in aging patients with atrial fibrillation of Xinjiang Uygur and Han nationalities
This study explores the changes in gene and protein expression of tyrosine hydroxylase (TH) and growth-associated protein 43 (GAP43) in aging patients with atrial fibrillation of Xinjiang Uygur and Han nationalities. Real-time polymerase chain reaction (PCR) and Western blot were used to detect the gene and protein expressions of TH and GAP43 in atrial tissues of 54 patients with valvular heart disease....
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