Abstract

This study aims to investigate influences of different doses of hypisotonic non-ionic contrast agent (Iopromide) on renal function of elderly patients. A total of 30 cases of elderly patients without a history of nephrosis and with normal renal function were divided into two groups according to the different doses of received contrast agent. Influences of Iopromide on renal function were observed by detecting blood urea nitrogen (BUN), serum creatinine (Scr) and creatinine clearance rate (Ccr) at the postoperative 2nd and 5th day. There was no significant difference for BUN, Scr and Ccr levels before angiography and at the 2nd and 5th days after operation between two groups of patients (P > 0.05). At the postoperative 2nd day, Scr of two groups of patients slightly increased and Ccr slightly reduced. At the 5th day, they restored to the levels before angiography. Based on the results, we believe one dosage of not more than 294 ml non-ionic contrast agent Iopromide is relatively safe for elderly patients.

Key words: Non-ionic contrast agent, contrast induced nephropathy, elderly patients.