African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2243

Table of Content: 22 November, 2011; 5(19)

November 2011

Pre-formulation investigation and in vitro evaluation of directly compressed ibuprofen-ethocel oral controlled release matrix tablets: A kinetic approach

The objective of this study was to develop directly compressed oral controlled-release ibuprofen matrix tablets containing hydrophobic polymer (Ethocel®) of different viscosity gardes (Ethocel®standard 7P, 7FP, 10P, 10FP  100P and 100FP). As ibuprofen like other non-steroidal anti-inflammatory drugs has dosage frequency and severe gastrointestinal tract (GIT) complications and patient...

Author(s): Abdul Wahab, Gul Majid Khan, Muhammad Akhlaq, Nauman Rahim Khan, Abid Hussain, Alam Zeb, Asim-ur- Rehman and Kifayat Ullah Shah

November 2011

Mohammad Talebi, Maryam Mashayekhi, Soodeh Rajabi, Mohammadreza Rahmani, Ali Roohbakhsh and Ali Shamsizadeh*

In our previous study, we reported that chronic morphine exposure changes neuronal response properties in rat somatosensory cortex. In this study, we investigated the effect of chronic morphine treatment on tactile learning behavior in rats. Morphine sulfate was dissolved in tap water, and was administered for 21 days. Tactile learning was assessed using the novel object recognition test (NORT) in a dark room. The...

Author(s): Mohammad Talebi, Maryam Mashayekhi, Soodeh Rajabi, Mohammadreza Rahmani, Ali Roohbakhsh and Ali Shamsizadeh

November 2011

Detection of bacteriocins in Zymomonas mobilis and RAPD fingerprinting of the producer strains

Six strains of Zymomonas mobilis were evaluated in relation to the ability of producingbacteriocin against Gram-negative and Gram-positive bacteria, including three strains ofEscherichia coli, one strain of Salmonella enteritidis and one strain of Staphylococcus aureus and Streptococcus faecalis. Two culture media and temperatures of 30 and 37°C were effective in the expression of...

Author(s): LIMA Gláucia Manoella de Souza, SOUZA Larissa Isabela Oliveira, ROSATO Yoko Bomura and ARAÚJO Janete Magali

November 2011

A semi-empirical study of flavone compounds with antioxidant efficiency

In spite of the large quantity of experimental work, the electronic and structural aspects of flavones responsible for free radical scavenging ability are theoretically analyzed in this paper. Electronic parameters were calculated using the AM1 semi empirical level to calculate a set of molecular properties for flavone compounds. The electronic features found as being responsible for the antioxidant activity of the...

Author(s): M. Rajendran, M. Mahalakshmi, R. Ramya and D. Devapiriam

November 2011

Potentiation of in vitro antibiotic activity by Ocimum gratissimum L.

Escherichia coli is known to produce enterotoxins, whose properties and its role in diseases causing diarrhea has been investigated. Some species of Staphylococcus are often recognized as etiological agents of many animal and human infections opportunistic. This study is the first test of antibiotics sensitivity against multi resistant strains of E. coli and Staphylococcus...

Author(s): Luana Kamila A. Braga, Aruan Kawally C. de Macedo, Ariathanna A. Cunha, João Marcos F. L. Silva, Francisco A. V. Santos, Celestina E. S. Souza, Henrique D. M. Coutinho, Thiago S. Almeida, José G. M. Costa, and  Edinardo F. F. Matias,

November 2011

Phytochemical, physiochemical and anti-fungal activity of Eclipta alba

Eclipta alba, commonly known as False Daisy is an important medicinal plant and its different parts are famous for the treatment of different health problems including digestion, headache, asthma, cough and normalizing skin colour. Keeping in view the importance of E. alba, it was analyzed quantitatively, qualitatively for its phytochemicals (alkaloids, flavonoids, saponins, tannins, glycosides, terpenoids,...

Author(s): Iqbal Hussain, Naeem Khan, Riaz Ullah, Shanzeb, Shabir Ahmed, Farhat Ali Khanand Sultan Yaz

November 2011

Effects of physical activity on some of hemostatic parameters changes in epiphysectomized rats

This study was designed to determine the effects of physical activity on thrombin time and coagulation time in epiphysectomized rats. Male Wistar rats (n = 60) weighing 90 to 100 g were divided into 2 groups; control group (without epiphysectomy) and experimental group (epiphysectomy). In each group, animals were divided into three subgroups: control (without physical activity), short-time (5 min physical activity) and...

Author(s): Hossein Rostami, Ali Aliyev, Valida Madatova and Ali Arasteh

November 2011

Phytoconstituent screening and antimicrobial principles of leaf extracts of two variants of Morus alba (S30 and S54)

Efficacies of the two variants of Morus alba locally grown in Forestry Research Institute of Nigeria, were investigated following the recommended procedure of analysis. Phytochemical, proximate and mineral compositions of M. alba leaves were determined using a standard procedure. Antimicrobial properties of leaf extracts of M. alba were also investigated against laboratory standards of both...

Author(s): O. A. Ayoola, R. A. Baiyewu, J. N. Ekunola, B. A. Olajire, J. A. Egunjobi, E. O. Ayeni and  O. O. Ayodele

November 2011

Attenuation of oxidative stress of hepatic tissue by ethanolic extract of saffron (dried stigmas of Crocus sativus L.) in streptozotocin (STZ)-induced diabetic rats

Oxidative stress is an underlying mechanism of diabetes mellitus complications. The aim of this study was to evaluate the effect of saffron ethanolic extract on oxidative stress of hepatic tissue in streptozotocin (STZ)-induced diabetic rats. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were measured to assess free radical activity in the liver tissue. Hepatic antioxidant activities of glutathione...

Author(s): Rahbani Mohammad, Mohajeri Daryoush, Rezaie Ali, Doustar Yousef and Nazeri Mehrdad

November 2011

Effects of vitamin E and thymoquinone on physiological and histological characteristics of heat-stressed male mice

Previous studies have shown that heat stress can lead to tissue damage and multiple organ dysfunctions. The present study elucidates the negative effects of heat stress and the possible protective effects of vitamin E or thymoquinone against the physiological and histological consequences of heat stress. Forty male mice were distributed into four groups as follows: group I was a control group that was orally...

Author(s): Saeed Al-Zahrani, Saleh Kandeal, Mohamed Mohany and Gamal Badr,