October 2011
A gender wise study of arylamine N-acetyltransferase 2 (NAT2) acetylation phenotyping using sulphamethazine by high-pressure liquid chromatography (HPLC) assay
The acetylation polymorphism is one of the most common inherited variations in the biotransformation of drugs and chemicals and large number of studies has been done to determine the distribution of acetylator phenotypes among populations of different geographic origin. The aim of this study was to investigate the acetylator phenotypes of the Pakistani population and compare it between male and female healthy...
October 2011
Curcumin induce apoptosis of CNE-2z cells via caspase-dependent mitochondrial intrinsic pathway
Nasopharyngeal carcinoma (NPC) is an epidemic malignant cancer in Southern China and Southeast Asia. Curcumin, an edible yellow pigment, has been shown to exert an anti-cancer activity in several tumor types. In this study, the effects of curcumin on cell growth and apoptosis were examined in the human NPC cell line CNE-2z, using the 3-(4,5-dimethythiazol-. 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and...
October 2011
Formulation, optimization and biopharmaceutical evaluation of the fast release tablets of nifedipine-cyclodextrin
In this study, nifedipine tablets were formulated with different types of cyclodextrins (CDs) by direct compression method. Spray dried lactose and microcrystalline cellulose (MCC) were used as tablet fillers. The prepared tablets showed good appearance with acceptable crushing strength and disintegration time. The tablets showed fast dissolution within 11 to 68 min for 80% of the drugs depending on the type of CD and...
October 2011
Sevoflurane pretreatment prevents lipopolysaccharide (LPS)-induced acute lung injury in rats through up-regulated heme oxygenase-1 (HO-1) expression
To observe the effect of sevoflurane pretreatment with different concentrations on lipopolysaccharide (LPS)-induced acute lung injury (ALI) and expression of heme oxygenase-1 (HO-1). Sprague-Dawley (SD) rats were divided into six groups in different sevoflurane pretreatment experiment, Group A (control), Group B (1.5 MAC sevoflurane), Group C (1.5 MAC sevoflurane + LPS), Group D (1.0 MAC sevoflurane + LPS), Group E (0.5...
October 2011
Bioequivalence assessment of two formulations of celecoxib: Open label, single dose and two-way cross over study in healthy human male volunteers
The purpose of this study was to assess bioequivalence of two marketed formulations of celecoxib capsules in healthy human male volunteers. The study was conducted according to a single dose, randomized sequence, open label, two-period and crossover design. Both test and reference formulations comprised labeled dose of 200 mg celecoxib and were administered to each subject after an overnight fasting on two treatment...
October 2011
Comparative therapeutic efficacy of tiamulin and pulmotil in infected broiler and layer flocks with Mycoplasma gallisepticum
Chronic respiratory disease (CRD) is one of the most important veterinary diseases in Iran and all over the world. Mortality, reducing of weight gain and increasing of feed conversion ratio (FCR) are caused by CRD. Several drugs are used for prevention and control of CRD. CRD is caused by Mycoplasma gallisepticum (MG). Tiamulin and pulmotil are effective on M. gallisepticum. By considering generating...
October 2011
Antibacterial constituents of the leaves of Dacryodes edulis
Dacryodes edulis is a dioecious, small to medium-sized tree, reaching 20 to 25 m high. Different parts of the plant are used to treat many diseases including skin infections, digestive tract disorder and dysentery. The leaves were macerated in 50% ethanol and the liquid extract concentrated to dryness. The dry extract was evaluated for antibacterial activity by using agar diffusion method. The extract was...
October 2011
Levels of antioxidant vitamins in newly diagnosed cases of type 2 diabetes mellitus in South Eastern Nigeria
Free radicals have important roles in pathogenesis of diabetes mellitus. It has been well documented that there is a link between oxidative stress and secondary complications of diabetes mellitus. However, humans are well endowed with antioxidant defences, primarily by free radical scavengers, such as Vitamins A, C, E and some trace elements. Deficiencies of these micronutrients may increase susceptibility to this...
October 2011
Evaluation of mineral element contents in Paris polyphylla var. yunnanensis from Southwest China
Paris polyphylla var. yunnanensis is known to be used as medicine for anti-cancer and traumatic injuries. The present investigation was carried out to estimate the mineral elements in P. polyphylla var. yunnanensis collected from different locations of South West China by atomic absorption spectroscopy. The contents of its mineral elements were found in the order of Ca > K...
October 2011
In vivo antidiarrheal activity of the ethanolic leaf extract of Catharanthus roseus Linn. (Apocyanaceae) in Wistar rats
Catharanthus roseus is a medicinal plant with various pharmacological properties. In this study, we investigated the in vivo antidiarrheal activity of C. roseus ethanolic leaf extract in Wistar rats. Castor oil was used to induce experimental diarrhea in rats pretreated with extracts administered at 200 and 500 mg/kg to determine antidiarrheal effect. Loperamide and atropine sulphate were used...
October 2011
Formulation development and characterization of propranolol hydrochloride microballoons for gastroretentive floating drug delivery
The purpose of this research was to prepare floating microballoons consisting of (i) calcium silicate as porous carrier; (ii) propranolol hydrochloride (PRH), an oral anti-hypertensive agent; and (iii) Eudragit S as polymer, by solvent evaporation method and to evaluate their gastro-retentive and controlled release properties. The effect of various formulation and process variables on the particle morphology,...
October 2011
Immunomodulatory potential of Phlomis bracteosa
The present study reports the immunomodulatory activities of different crude fractions ofPhlomis bracteosa. In case of immunomodulatory study, the ethylacetate fraction demonstrated significant modulatory effect for oxidative burst of polymorphoneutrophils and CHCl3 crude fraction for the whole blood, while the aqueous fraction demonstrated reasonable inhibition. Hence, both the chloroform and ethylacetate...
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