The effect of surfactant above and below the critical micelle concentration (CMC) and the mathematical models used to determine the kinetics of drug release from the matrix system
The liberation of propranolol HCl from a controlled release matrix, containing the hydrophilic polymer, sodium carboxymethylcellulose (NaCMC) and the hydrophobic polymer, Eudragit RL 100 (RL 100) as excipients, was studied. The influences of surface active agents on the dissolution rate of the drug were examined. Tablets were made by direct compression methods. The dissolution tests were performed by using the basket...
Biochemical parameters and Histomorphometric cardicac evaluation among Wistar rats treated with chia seed (Salvia hispÃ¢nica L.): Experimental model
The advance of global economy affects developing countries that are facing a major public health problem. The prevalence of obesity triggers a series of non-communicable chronic diseases (NCDs). Several studies have suggested that the chia seed (Salvia hispânica L.) may be an alternative to combat NCDs, as it is rich in alpha-linolenic acid (ALA). This research is an experimental work in which 24 Wistar rats were...
Combination of lauric acid and myristic acid prevents benign prostatic hyperplasia (BPH) symptoms in animal model
Benign and uncontrolled growth of prostate gland is known as benign prostatic hyperplasia (BPH). It is a common health issue that affects 8% of all men at the age of 40, 60% of men in their 70s, and 90% of those greater than 80 years of age. In this study, we investigated whether a combination of lauric and myristic acid improved BPH in a testosterone propionate (TP)-induced model of BPH in rats. BPH was induced in the...
Evaluation of the extracts of Morinda lucida and Tridax procumbens for anti-trypanosomal activity in mice
A major problem besetting the chemotherapy of African Trypanosomiasis is parasite resistance to the few available drugs, and a known strategy is to use combination of drugs to overcome parasite drug resistance. An attempt has been made in this study to explore the potential of Tridax procumbens and Morinda lucida individually as single therapy and as combination therapy in the treatment of trypanosomiasis. The effective...