African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2145

Table of Content: 29 June, 2012; 6(24)

June 2012

Sero-surveillance of measles amongst vaccinated and non-vaccinated children: An age stratified population based survey in Pakistan

Measles is one of the most contagious human diseases; it remains a leading cause of death among young children and its elimination is one of the major global public health priorities. It is estimated that in year 2008 approximately 100,000 deaths in children aged less than 5 years was attributable to measles. The increase in measles vaccination coverage in the developing world has produced significant changes in the...

Author(s): Rafique Ahmad Channa, Shahzad Hussain, Nisar Ahmad Kanher, Farnaz Malik, MazharUllah Memon, Sidra Mahmood, Fahdiya Yasin, Amina Wajid, Shazia Shafaat, Rashid Mahmood, Ghazala Parveen, Safia Ahmad and Muhammad Ismail

June 2012

Effect of process parameters on the properties of some metronidazole tablet and capsule formulations

This work was aimed at evaluating the properties of metronidazole capsules and tablets formulated by different methods in comparison with some commercially available tablet brands to ascertain the influence of formulation parameters and the unpopularity of clinical use of the capsule in Nigeria. Three batches of metronidazole 200 mg tablets were formulated by wet granulation, dry granulation and direct compression...

Author(s): Mbah C. C., Emosairue C. O., Builders P. F., Isimi C. Y., and Kunle O. O.

June 2012

Ethnobotanical study of medicinal plants used by the Laniba village people in South Western Nigeria

An ethnobotanical survey on medicinal plants used for treating and managing different ailments by the Laniba people who live in south western Nigeria was undertaken. The study was conducted using unstructured interviews among both male and female herbalists, herb sellers and experienced village elders. Information on traditional uses and remedies were documented. Twenty-one plants belonging to fifteen families were...

Author(s): Mubo A. Sonibare and R. B. Abegunde

June 2012

Osteoblastic activity of ethanolic extract and volatile compounds from Er-Zhi-Wan, a famous traditional Chinese herbal formula

Er-Zhi-Wan (EZW), a famous traditional Chinese formula, which is comprised of the aerial parts of Eclipta prostrate L. (EP) (Astraceae) and the fruits of Ligustrum lucidum Ait. (FLL) (Oleaceae) has been developed as a restorative formula for hundreds of years. It is widely used to prevent and treat various kidney diseases. This study aimed to investigate the effects of volatile components and...

Author(s): Yan-Bin Wu, Jian-Guo Wu, Jun Yi , Ti-Qiang Chen, Xiong-Hao Lin and Jin-Zhong Wu

June 2012

Comparative study of drug intervention in treatment of rural middle-aged and elderly people with knee osteoarthritis in Fengxian District, Shanghai

The aim of this study is to perform intervention treatment with loxoprofen, diacerein and glucosamine for middle-aged and elderly knee osteoarthritis (KOA) patients and compare the efficacy and safety of the aforementioned three drugs on KOA as well as providing basis for standard treatment protocol for the exploration of KOA. 153 KOA patients who were proved in the project of KOA epidemiological survey on rural...

Author(s): Yongbin Wang, Xiaoyun Huang, Bin Song and Zhihong Song

June 2012

The effect of destrin mutations pathways on the gene expression profile

Corneal disease is responsible for the main cause of bilateral blindness in the world, second only to cataract. As an essential actin binding protein, destrin mutation often result in cytoskeleton dynamics abnormalities in corneal epithelial surface, and thus, cause corneal epithelial cell hyperproliferation, inflammation, and angiogenesis, namely, corneal diseases. In this study, we explored the interaction and...

Author(s): Qinghua Zhou, Yun Li and Baihua Chen

June 2012

The menace of opiate: The socio-psychological and physiological impacts of opiate on addicts in Khyber Pakhtunkhwa, Pakistan

Opiate addiction is a menace and a matter of concern throughout the world, being one of the most hazardous aspects of personal as well as the societal course of life of an individual. This study describes the socio-psychological and physiological impacts of opiate on addicts in Khyber Pakhtunkhwa Province of Pakistan. Data were collected from 100 pure opiate addicts through simple random sampling technique using...

Author(s): Arab Naz, Waseem Khan, Mohammad Hussain, Umar Daraz, Tariq Khan and Qaisar Khan

June 2012

Anxiolytic and anti-nociceptive activity of hydroalcholic leaf extract of Cnidoscolous acontifolius

The Cnidoscolous acontifolius hydroalcholic leaf extract (CAHLE) has been described as exhibiting biological activity in the central nervous system assays. The objectives of this study were to investigate the anxiolytic and antinociceptive effects of CAHLE in mice. Swiss albino mice (18 to 22 g) were randomly allotted to thirteen groups (n = 5 each). Groups 1 to 5 and 9 to 13 were treated with graded doses of CAHLE...

Author(s): O. A. Adebiyi, O. O. Adebiyi, O. R. Ilesanmi and T. Adu

June 2012

Comparative effect of fennel extract on the intensity of primary dysmenorrhea

Primary dysmenorrhea is described as pelvic pain around the time menstrual bleeding in the absence of an identifiable pathologic lesion. It is a common gynecologic problem among women in reproductive age groups. Our objective was to compare the effect of vitamin E and fennel extract on the intensity of primary dysmenorrhea. A randomized single blind placebo-controlled trial was used among 65 single female students who...

Author(s): Moslemi L., Bekhradi R., Galini Moghaddam T. and Gholamitabar Tabari M.

June 2012

Evaluation of antioxidant activity of fermented soybean meal extract

The antioxidant activities of fermented soybean meal (FSM) extract were evaluated by various methods in vitro and in vivo. The antioxidant tests in vitro, included the total phenolic and flavonoid content, reducing activity, 1,1-diphenyl-2-picryl-hy-drazyl (DPPH·) and superoxide anion radical scavenging activity, inhibition of lipid peroxidation in rat liver homogenate and erythrocyte...

Author(s): Xuejuan Yang, Jun Chen, Chunxiao Zhang, Hua Chen and Youbin Liu

June 2012

Evaluating the anti-metastatic potential of Anisomeles indica extract by using human oral squamous carcinoma FaDu cells

Our previous study demonstrated that Anisomeles indica hexane extract (AIE) can induce cellular death in FaDu human pharynx squamous cancer cells by apoptosis. This study investigates the anti-metastatic effect of AIE on FaDu cells. First, the starting material of A. indica was confirmed based on nucleotide sequence analysis of ITS1, 5.8S and ITS2 of rDNA. The inhibitory effects of AIE on migration...

Author(s): Hsia-Fen Hsu, Zi-Hua Chen, Shih-Fan Chang, Chao-Ping Wang, Shu-Jiau Chiou, Jui-Hung Yen, Chi-Chang Chang, Yu-Duan Tsai, Li-Wen Fang and Jer-Yiing Houng,

June 2012

Clinical study on the treatment of infant cytomegalovirus (CMV) hepatitis intervened by traditional Chinese medicine

To evaluate the efficacy and safety of Chinese medicine (CM) in treating infantile cytomegalovirus hepatitis (ICH), a total of 43 infant ICH patients were randomly divided into two groups, 22 in the treatment group and 21 in the control group. The treatment group: patients were treated with Qinggan Lidan decoction (QLD) during icteric stage and Yigan Jiangmei decoction (YJD) in non-icteric hyper-aminotransferase stage...

Author(s): HU Yan, YAO Yuan and ZHAO Yu-hao 

June 2012

Efficacy of a Chinese herbal formula in patients with stable angina pectoris based on doctor and patient reported outcomes

This research aimed at evaluating the clinical curative effect of Blood Mansion Stasis-Expelling Decoction and its refining prescription on stable angina pectoris through double-blind randomized controlled trial based on doctor and patient reported outcomes. Patients (92) were randomly grouped into Groups A, B, and C, and were separately given Blood Mansion Stasis-Expelling Decoction, refined Blood Mansion...

Author(s): Xiao-ke Li,#, Lu Jing#, Peng Lu#, Qing-yong He, Xing-jiang Xiong, Kui-wu Yao, Li-li Guo, Jie Wang and Jian-xin Chen

June 2012

Evidence based study of side effects of drugs used in the treatment of diabetes mellitus

Diabetes mellitus occurs throughout the world but is more common in developed countries. More than 150 million people were found with diabetes in 2004. In 2005, there were about 20.8 million people with diabetes in United State alone. While an estimated 14.6 million have been diagnosed with diabetes, unfortunately 6.2 million were unaware that they have diabetes. To focus on the adverse effects of drugs prescribed for...

Author(s): H. M. S. Khan, G. Murtaza, M. Usman, F. Rasool, M. Akhtar, M. I. M. Qureshiand K. Farzana