African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 29 June, 2013; 7(24)

June 2013

Neurofibromatosis 1 with invasive spinal cord compression (case report)

Neurofibromatosis, being found as one incident in 2500-3000 births, is a genetic disease that involves either skin system, nervous system or both systems simultaneously and that leads to important cosmetic and functional disorders. Although, cervical cord compression is not frequently found in nervous system compression, nevertheless, it takes a very important place since it may lead to severe neurological deficits and...

Author(s): Mustafa GÜLER, Teoman AYDIN and Emine POYRAZ

June 2013

Evaluation of the antioxidant properties of Vitis vinifera juice extract in rifampicin dispersions

The purpose of this  study was to evaluate the antioxidant properties of Vitis vinifera juice extract (grape) in rifampicin suspensions and to compare with that of ascorbic acid. Grape juice was extracted and used as antioxidant in both pure sample and commercial reconstituted  samples of rifampicin. The rate of drug degradation was determined by spectroscopic method in a time dependent manner. Also,...

Author(s): Ikechukwu V. Onyishi, Salome A. Chime and Cynthia Okeke

June 2013

Evaluation of mechanism of hepatotoxicity of leflunomide using albino wistar rats

Leflunomide (LEF) is used for the treatment of rheumatoid arthritis via inhibition of dihydroorotate dehydrogenase and tyrosine kinase enzymes. It is metabolised by cytochrome 2C9 enzyme to active form A771726 (melononitrilamide) which is responsible for both its pharmacological and toxicological responses. Food and Drug Administration (FDA) gave black box warning in 2010 due to acute liver failure in humans....

Author(s): Ram Lal Lodhi, Siddhartha Maity, Pradeep Kumar, Shubhini A Saraf, Gaurav Kaithwas, Sudipta Saha

June 2013

Antimicrobial activities of some herbal anti-infectives manufactured and marketed in South-East Nigeria

The aim of this study was to evaluate the anti-microbial activities of some liquid herbal anti-infectives manufactured and marketed in South-Eastern Nigeria and determine the extent of their microbial contamination. Twenty samples were randomly collected from herbal shops in the five states that make up the South-East Nigeria. Antibacterial activities of the herbal preparations were evaluated using agar-well-diffusion...

Author(s): Ujam Nonye T., Oli Angus N., Uzodinma Samuel U., Ikegbunam Moses N., Anagu Linda O., Adikwu Michael U. and Esimone Charles O.

June 2013

Effects of Saikosaponin D on apoptosis genes expression profile of the colon cancer cells HT-29

The present study aims to investigate the change of apoptosis genes expression of HT29 cells induced by Saikosaponin D (SSD), which is the major component of Xiao Chai Hu Tang, the classic Chinese medicine prescriptions. In this study, gene expression profiles of HT29 cells with or without the SSD treatment were obtained by means of using RT ProfilerTMPCR Array Human Apoptosis and quantitative real-time polymerase chain...

Author(s): Min Lu, Haoran Sunlu, Jing Yang, Liang Wang

June 2013

Electrophysiological changes in response to L-arginine infusion in isolated mammalian heart

Arrhythmia is one of the major detrimental risk factors for cardiac arrest and death especially those associated with prolonged Q-T interval. Several antiarrythmic and cardiac agents prolong the Q-T interval as class I-a and class III anti-arrythmic agents. The cGMP is an important second messenger formed by the NO induced-guanylyl cyclase  in response to L-arginine infusion. The aim of the present work is to...

Author(s): Samy Eleawa and Hussein F. Sakr,

June 2013

Protective effects of oxysophoridine on alcoholic hepatic injury in mice

The aim of study is to detect the effects and relevant mechanisms of oxysophoridine on alcoholic hepatic injury in mice. Sixty male Institute of Cancer Research (ICR) mice were randomly divided into a normal control group, an alcoholic liver injury model group, a positive control (tiopronin) group and an oxysophoridine (250, 125, 62.5 mg/kg) group. Consecutive interventions were conducted on each group for 10 days;...

Author(s): Ying Zhao#, Yi Zhang#, Yu-Xiang Li, Nin Jiang, Xiao-Ping Chen, Yin-Ju Hao, Ling Ma, Yan-Rong Wang, Tao SUN, Jian-Qiang Yu

June 2013

The neuroprotective role of Nigella sativa extract on ciprofloxacin and pentylenetetrazole treated rats

This study aimed to investigate the Nigella sativa seed (NS) neuroprotective effect on ciprofloxacin (CFX) antibiotic with suggesting neurotoxic effect in rats through the determination of monoamines levels and acetylcholinesterase (AChE) activity in different brain areas. We used valporic acid as a reference antiepileptic drug and pentylenetetrazole (PTZ), a drug used for induction of epileptic model in rats....

Author(s): Mona Abdel-Rahman , Nadia M. S. Arafa, Manal F. El-khadragy, Rami B. Kassab

June 2013

Influence of a Ginkgo biloba extract on the binding of [F-18]-fluorodeoxyglucose (18F-FDG) on blood constituents

  Radiopharmaceuticals are used in procedures of nuclear medicine for the diagnosis and treatment of illnesses. Fluorine-18(18F) is a positron emitter produced in cyclotron. It is used to get 18fluorodeoxyglucose (18F-FDG) that is a radiopharmaceutical utilized in the positron emission tomography scan. The aim of this work was to evaluate the in vitro effect of an extract of Ginkgo biloba extract (EGb) on the...

Author(s): Luiz Cláudio Martins Aleixo, Silvana Ramos Farias Moreno, Rosimeire de Souza Freitas, Gláucio Feliciano Diré, Sebastião David Santos-Filho, and Mario Bernardo-Filho,

June 2013

Gabapentin as an adjuvant treatment in renal colic: A randomized double-blind clinical trial

Acute renal colic probably is the most painful event a person can endure and pain relief with minimal side effects is a humane approach. Gabapentin is an antiepileptic drug, also used in the treatment of neuropathic pain but it’s efficacy and safety in treating renal colic has not been demonstrated. We studied patients with renal colic to assess the efficacy and safety of single dose of 600 mg oral Gabapentin...

Author(s): Goodarzi D., Cyrus A., Baghinia M. R., Sameni D.