March 2013
Effect of the methanolic extract of Brachylaena discolor in a streptozotocin-induced diabetic rat model
Traditionally, leaf infusions of Brachylaena discolor are used for the treatment of diabetes and renal conditions. Therefore, the aim of this study was to evaluate the effect of a methanolic leaf extract of B. discolor in a streptozotocin (STZ)-induced diabetic rat model. Diabetes was induced in Wistar rats by an intraperitoneal injection of STZ; blood glucose levels greater than 20 mmol/L measured...
March 2013
The effect of hydroxy safflower yellow A on inflammatory reaction in myocardium of the rats after acute myocardial infarction
This study was designed to investigate the effect of hydroxy safflower yellow A (HSYA) on inflammatory reaction in ratmyocardium after acute myocardial infarction (AMI). 138 male Wistar rats were randomly divided into six groups: normal group, sham group, control group, injecting SY positive control group (SY group, 90 mg/kg), HSYA high-dose group (HSYA-H group, 40 mg/kg), and HSYA low-dose group (HSYA-L group, 20...
March 2013
Quantitative determination of lappaconitine in plasma by liquid chromatography-tandem mass spectrometry and its application in the pharmacokinetic study in rabbits
A high sensitive and rapid method was developed for the analysis of lappaconitine in rabbit plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Blood was taken from the ear vein after transdermal administration of lappaconitine gel on the back of male rabbits, followed by liquid-liquid extraction with n-hexane from plasma, the analyte was separated in an Inertsil ODS-3 column (2.1×50mm,...
March 2013
Development and pharmacokinetic evaluation of once-daily sustained-released matrix capsules of nifedipine using solid dispersion technique
The purpose of this study was to develop once-daily sustained-release matrix capsules of nifedipine (F1) using the combination of solid dispersion and drug controlled release techniques. F1 were prepared by the wetting granules methods using hydroxypropyl methyl cellulose (HPMC) as hydrophilic retard drug release agent and ethylcellolulose (EC) ethanol solution based on the polyvinyl pyrrolidone / stearic acid solid...
March 2013
Synthesis of folic acid-modified Fe3O4 nano-magnetic fluid for in vivo tumor cell labeling
Iron (II, III) oxide (Fe3O4) nanoparticles modified with folic acid were synthetized and effectively mediated into the tumor cells through the binding of folate and folic acid receptor. This study made us know the method of synthesis of folic acid-modified Fe3O4 nano-magnetic fluid and elucidate in vivo labeling effect of folic acid-modified Fe3O4 nano-magnetic fluid on the hepatoma cells in...
March 2013
Hepatoprotective and antioxidant effect of corosolic acid on carbon tetrachloride induced hepatotoxicity
The present study was designed to investigate the hepatoprotective and antioxidant properties of corosolic acid (CRA) on carbon tetrachloride (CCl4)-induced liver damage in rats. Liver damage was induced by giving a single oral dose of CCl4 (1:1 in liquid paraffin) at 1.25 ml/kg body weight (BW). Rats were pretreated with CRA dose of 10, 20 and 40 mg/kg BW (once daily for 7 days before CCl4 intoxication)....
March 2013
Study on utilization and efficacy of commonly used anthelmintics against gastrointestinal nematodes in naturally infected sheep in North Gondar, North-Western Ethiopia
Anthelmintic utilization and efficacy of commonly used anthelmintics against gastrointestinal nematodes in naturally infected sheep were assessed in North Gondar, North-Western Ethiopia. Anthelmintic utilization data were collected with a semi-structured questionnaire. An efficacy trial was conducted on 28 naturally infected sheep. The animals were randomly allocated into seven groups (four in each). Groups were treated...
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