In vivo cytotoxic effects of methanol extract of Convolvulus arvensis on 7-12-dimethyl benz(a)antheracene (DMBA) induced skin carcinogenesis
A current study was conducted to evaluate the possible cytotoxic effect of Asian herb Convolvulus arvensis (methanolic extract), followed by 2 stage skin carcinogenesis protocol by tumor initiator, 7-12-dimethyl benz(a)antheracene (DMBA) and tumor promoter, Croton oil in Swiss albino mice. They induced 100% skin ulceration in carcinogen control and cumulative number of papilloma (CP), tumor yield (TY) and tumor burden...
Gastroretentive drug delivery systems: A review
Oral administration has only limited use for important drugs from various pharmacological categories, that have poor oral bio-availability due to incomplete absorption and/or degradation in the gastrointestinal tract (GIT). Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short half-life are eliminated quickly from the blood circulation, so they require frequent dosing. To avoid this...
Synthesis and antifungal activities of some benzimidazolyl-chalcones, analogues of chlormidazole
We report here the synthesis of new benzimidazolyl-chalcones analogues of chlormidazole in order to contribute to the development of new antifungal drugs. Benzimidazolyl-chalcones were obtained by reaction of various aromatic aldehydes (7) with N-(4-chlorobenzyl)-2-acetylbenzimidazole (5) and its precursor 2-acetylbenzimidazole (4). After confirming their structure using spectroscopic methods (1H and 13C NMR, MS in EI...
Antitoxic effect of baicalin and glycyrrhetic acid on PC12 cells induced by Aconitum brachypodum Diel
The roots of Aconitum brachypodum Diel are used clinically in traditional medicine of China. However, it is also found very toxic and to date, few detoxication strategies are available to completely eliminate its toxicity. The present study was conducted to observe the cellular neurotoxicity of A. brachypodum Diels and discuss the detoxication effect of baicalin and glycyrrhetic acid, two compounds from Chinese herbal...
Effect of piperine on pentylenetetrazole induced seizures, cognition and oxidative stress in mice
Cognitive impairment in epileptics may be a consequence of the epileptogenic process as well as antiepileptic medication. Thus, there is need for drugs, which can suppress epileptogenesis as well as prevent cognitive impairment. In the present study, the effect of piperine was evaluated on the course of pentylenetetrazole (PTZ) induced seizures, learning deficit and oxidative stress `markers in mice. Male albino mice...
Evaluation of metronidazole suspensions
Most of the formulations of metronidazole suspensions available in circulation tend to have the problem of caking or claying probably due to the flocculation behavior of the dispersed phase. The present study attempts to achieve a desirable flocculation pattern by the use of a polysaccharide, Abelmoschus esculentus (Okra) mucilage alone and then in combination with a monovalent electrolyte and sodium sesquicarbonate...