African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2159

Table of Content: 8 December, 2012; 6(45)

December 2012

Aminonaphthoquinones as potential anti-breast cancer agents

A small library of compounds, including aminonaphthoquinones, heterocyclic and aromatic compounds, was synthesized to determine their antiproliferative activity against three mammalian cancer cell lines viz:cervical carcinoma (HeLa), breast adenocarcinoma (MCF-7) and T-cell leukaemia (Jurkat). Investigations into the effect of the compounds on coagulation and platelet activity were also undertaken. In particular, the...

Author(s): Hajierah Davids, Reza Theunissen, Santanu Chakravorty, Raushaan Mohammed, Carminita Frost, Willem A. L. van Otterlo and Charles B. de Koning

  • Article Number: 8F1135527362

December 2012

Free radical scavenging activity of Chinese traditional four substances decoction (FSD) extracts

This article examined the interactive effect among herbs extracts in combined use, compared with the effect of individual herbal extracts on 1,1-diphenyl picryl hydrazyl (DPPH). The Chinese traditional prescription, four substances decoction (FSD) consisted of 25 g ofAngelica sinensis (Umbelliferae, AS), 6 g of Ligusticum chuanxiong Hort. (Umbelliferae, LCH), 10 g of Paeonia...

Author(s): Xin-Hong Wang

December 2012

Antioxidant and a-glucosidase inhibitory activity of red raspberry (Harrywaters) fruits in vitro

[2,2-azino-bis(3-ethylbenzothiazoline)-6-sulphonic acid] Diammonium salt (ABTS) radical scavenging and ferric reducing antioxidant power (FRAP) assay were used to analyze the antioxidant activity of red raspberry (Harrywaters, HW) fruits with 2,6-Di-tert-butyl-4-methylphrnol (BHT) as positive controls and α-glucosidase inhibitory activity of HW extracts with acarbose as positive control in vitro. HW fruits...

Author(s): Zhen-hua Yin, Jia-jia Wang, Xue-zhu Gu, Hai-peng Gu and Wen-yi Kang

December 2012

Effect of hyaluronic acid and vitamin E vaginal tablets on atrophic vaginitis: A randomized controlled trial

The aim of this study was to compare the effectiveness of the vaginal tablet of hyaluronic acid and vitamin E in the treatment of atrophic vaginitis. This randomized, double-blind comparisonstudy was carried out on 40 postmenopausal women with symptoms of vaginal atrophy at number one health educational center of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran from August to December...

Author(s): Sara Ziagham, Zahra Abbaspoor and Mohammad Reza Abbaspour

December 2012

Phytochemical, antioxidant and cytotoxic activities of Periploca aphyla and Mentha longifolia, selected medicinal plants of District Bannu, Pakistan

Mentha longifolia and Periphloca aphyla are a well known species widely applied in medicine as a constituent of various drugs, and are very liked in aromatherapy. The current study was desighned to investigate the phytochemical screening, cytotoxic and antioxidant capacity of methanolic extract of Mentha longifolia and Periphloca aphyla. The methanolic extract...

Author(s): Rahmat Ali Khan, Noor Aslam Khan, Farid Ullah Khan, Mushtaq Ahmed, Abdul Saboor Shah, Muhammad Rashid Khan and Mir Sadiq Shah

December 2012

Proteomic analysis of oxymatrine-induced changes in lung fibroblasts

Oxymatrine, one kind of alkaloids extracted from Sophora flavescens Ait, has been demonstrated to attenuate bleomycin-induced lung fibrosis. The mechanisms of this action are poorly known. This study aimed to use proteomics to provide new insights into the mechanisms of the pharmacological effects. Proteins from murine lung fibroblasts exposed to oxymatrine were separated by two-dimensional electrophoresis....

Author(s): Xiao-Hong Chen, Ren-Shan Sun, Yi-Ran Li, Dong-Jiang Liao, Zi-Yao Mo, Zi-Feng Yang, Jian-Ming Hu, Wen-Da Guan and Nan-Shan Zhong

December 2012

Effects of different manufacturing methods on pharmaceutical properties and release kinetic models of ketoprofen sustained-release microparticles

Extrusion-spheronization and the fluid bed method are valuable commonly applied methods in microparticle production. However, the characteristics of resultants prepared by these two methods have seldom been compared. The aim of this study was to investigate differences in pharmaceutical properties and release kinetics of sustained-release ketoprofen microparticles prepared by different manufacturing processes....

Author(s): Thau-Ming Cham, Shiao-Feng Huang, Tong-Rong Tsai, Yuh-Tyng Huang, and Wen-Ho Chuo

December 2012

The level of awareness and use of anticoccidials in poultry farms in South Western Nigeria

This study investigated the level of awareness and usage of anticoccidial drugs and vaccines by poultry farms in southwestern geopolitical zones of Nigeria, using Lagos, Oyo, and Ogun states. A researcher-made questionnaire was administered to the selected poultry farms, poultry attendants and veterinarians. With the deduction of an attrition value of 10% on questionnaire retrieval, data from 72 respondents out of 80...

Author(s): R. O. A. Arowolo, K. O. Soetan, O. O. Arowolo and O. O. Sodimu