Abstract

A small library of compounds, including aminonaphthoquinones, heterocyclic and aromatic compounds, was synthesized to determine their antiproliferative activity against three mammalian cancer cell lines viz:cervical carcinoma (HeLa), breast adenocarcinoma (MCF-7) and T-cell leukaemia (Jurkat). Investigations into the effect of the compounds on coagulation and platelet activity were also undertaken. In particular, the aminonaphthoquinones showed significant antiproliferative activity against the three cell lines, with aminonaphthoquinone4 showing more potent antiproliferative activity when compared to camptothecin (PC). This quinone was also identified as possessing significant antiplatelet activity in vitro, by inhibiting both platelet aggregation and platelet adhesion.

Key words: Aminonaphthoquinones, anticancer activity, anticoagulant, antiplatelet.