African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2142

Table of Content: 8 February, 2012; 6(5)

February 2012

Antioxidant and free radical scavenging activity of ethanolic extract of the root of Morinda citrifolia (Rubiaceae)

The aim of this work was to estimate the total phenolic and flavonoid content, and to evaluatein-vitro antioxidant activity of ethanolic root extract of Morinda citrifolia (MCREt) which belongs to the family Rubiaceae. The raw, dry root powder was extracted with 99.9% of ethanol. Phytochemical test shows that the extract contains higher level of total phenol and flavonoids. Total phenolic compound in...

Author(s): Ranju Pal, Kundlik Girhepunje, Ashutosh Upadhayay and Thirumoorthy N.

February 2012

Prognostic value of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes

The aim of this study was to compare the predictive value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other frequently used biomarkers, such as creatine kinase (CK), creatine kinase-mB (CK-MB), cardiac troponin T (cTnT) and C-reactive protein (CRP) for systolic and diastolic left ventricular function (SLVF and DLVF), and adverse coronary events in patients with non-ST-segment elevation acute coronary...

Author(s): Svetlana Medjedovic, Vladimir Jakovljevic, Dusica Djordjevic, Danijela Randjelovic, Zoran Koprivica, Natasa Petronijevic, Nebojsa Tasic, Miroslav Pavlovic, Zarko Vucinic, Zvonko Sundric and Dragan M. Djuric

February 2012

Comparison of effects of iloprost and pentoxiphylline on walking capacity and skin oxygenation in diabetic patients with peripheral artery disease

Diabetes is in close relation with peripheral artery disease (PAD) and there are conflicting results regarding efficacy of iloprost in PAD. The aim of this study was to investigate the efficacy of iloprost in improving walking capacity and increasing oxygenation to diseased tissues in PAD patients with diabetes, compared to pentoxiphylline. Data of 80 patients wererecorded contemporaneously. Patients were divided...

Author(s): Aşkin Ender Topal and Mehmet Nesimi Eren

February 2012

Effects of 950 MHz mobile phone electromagnetic fields on the peripheral blood cells of male rabbits

Today, mobile phones are used frequently and held close to the body. It is believed that microwaves may interfere with the cellular signaling systems, affecting the mechanisms by which the cells balance their functions. The objective of this work is the evaluation of the influence of different intensities of 950 MHz cell phone electromagnetic field (EMF) on the hematological parameters of male rabbits. This study was...

Author(s): M. R. Sarookhani, A. Safari, M. Zahedpanah, M. Asiabanha Rezaei and V. Zaroushani

February 2012

The effect of mummy on the healing of bone fractures

Femoral and tibia fractures are considered the most common fractures in long bone fractures.Mummy is traditionally used to treat fractures. This study was performed to evaluate the effect of mummy on tibia and femoral bone healing in patients referred to Kashani Hospital in Shahrekord, Iran. In this non-interventional cohort study, the population consists of patients that were referred to Kashani Hospital in...

Author(s): Mortaza Dehghan and Abolghasem Sharifi Faradonbeh

February 2012

Protective effect of Launaea procumbens against KBrO3 induced nephrotoxicity in rats

Launaea procumbens is traditionally used in the treatment of renal dysfunction. In the present study, protective effects of L. procumbens against KBrO3-induced nephrotoxicity in rat were determined. In this study, 24 male albino rats (195 to 200 g) were equally divided into 4 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and DMSO (1 ml/kg b.w.); Group II was treated with KBrO3 (30 mg/kg...

Author(s): Rahmat Ali Khan, Muhammad Rashid Khan, Sumaira Sahreen, Naseer Ali Shah , Amir Muhammad Khan, Jasia Bokhari, Umbreen Rashid, Bushra Ahmad, Maria Shabbir, Naima Saeed, Shumaila Jan and Tayyaba Afsar

February 2012

Potassium antimony tartrate affects the chemical and metabolic status of glutathione in human blood: Ex vivo studies

Toxicity of metal elements and their salts are compromised usually because of therapeutic needs. Glutathione (GSH), a master antioxidant of human body, constitutes a major portion of natural redox system. GSH also strengthens the immune system and paces healing after surgery or infection. Compounds of antimony (Antimonials) are useful in the treatment of leishmaniasis and schistosomiasis. As the compounds cause...

Author(s): Kifayatullah Shah, Muhammad Farid Khan, Amir Badshah, Haroon Khan and Asim Urrehman

February 2012

Exploration of signal transduction mechanism of therapeutic action of Solanum nigrum

In modern world, the recognition, understanding and treatment with phytomedicines have been increased during the last few decades. However, in spite of the progress in the field of research, the mechanism of therapeutic action of most of the phytomedicine remains unknown. Because of special interest with reference to our previous work, further in depth study was carried out onSolanum nigrum leaves and fruit (red...

Author(s): Mansoor Ahmad, MehJabeen and Noor Jahan

February 2012

Hepatoprotective effect of Mitragyna rotundifolia Kuntze on CCl4-induced acute liver injury in mice

In the previous studies, it was revealed that Mitragyna rotundifolia Kuntze (MR) had strong antioxidant activity in vitro. Oxidative stress is considered to play a prominent causative role in the development of various hepatic disorders. n-Butanol extract from M. rotundifolia barks (MRBBU) and leaves (MRLBU) were investigated, and it played a protective role against carbon tetrachloride...

Author(s): Fang Gong, Zhen-hua Yin, Qitai Xu and Wen-yi Kang

February 2012

The effect of metformin and exercise on serum lipids, nitric oxide synthase and liver nitric oxide levels in streptozotocin-nicotinamide induced diabetic rats

The objective of this study was to determine the effects of metformin treatment and exercise intervention on lipid metabolism, nitric oxide (NO), nitric oxide synthase (NOS) and glucose levels in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats. Male wistar rats were used to conduct the study and they were  divided into five groups of 8 rats in each. These groups are: Control group,...

Author(s): Fahrettin Akyuz,  Neslihan Tekin,  Ozlem Aydın,  Halide Edip Temel and Burhanettin Isıklı

February 2012

A preliminary study on the evaluation of a novel gene delivery vector-TACS in vitro and in vivo via co-expressing hVEGF and hBMP genes to repair critical-size rabbit bone defects

Strategies using gene therapy by nonviral vector to improve bone regeneration have been under research in the past. However, transfection efficiency into local cells, such as marrow stromal cells (MSCs) by each vector is not always high. Now, we fabricate a novel gene vector-thiolated N-Alkylated chitosan (TACS) by modifying of chitosan to overcome this problem. TACS is synthesized by conjugation of thiol group and...

Author(s): Yu Wenyuan, Zhao Yu, Xing Yanli, Bai Xin, Fang Yuee, Zhang Lin, Ding Haoand Wang Banghe

February 2012

Can hydrogen retard the progression of osteoarthritis?

There is a direct relationship between reactive oxygen species (ROS) and the progression of osteoarthritis (OA). Hydrogen is considered as a selective antioxidant, which can neutralize the superfluous ROS. This investigation aimed to describe whether hydrogen can be used as a new treatment to retard the progression of OA based on recent studies. The peer-reviewed literature published prior to July, 2011 in the PubMed...

Author(s): Ding Li and WanChun Wang