February 2013
Novel topical drug carriers as a tool for treatment of psoriasis: Progress and advances
Psoriasis is a chronic inflammatory skin disease portrayed by erythematous, papulosquamous lesions. It is characterized by excessive growth and aberrant differentiation of keratatinocytes. The conventional topical treatments that have been used in the past, such as coal tar and dithranol, have low efficacy, poor aesthetic and cosmetic appeal, leading to poor patient compliance while systemic...
February 2013
Antimalarial drugs: Mode of action and status of resistance
Malaria is a major global health problem, with an estimated 300 to 500 million clinical cases occurring annually. Malaria remains one of the leading causes of disease and death in the tropics, mainly of children under 5 years of age. The most prevalent and dangerous type of malaria is caused by Plasmodium falciparum. P. vivax is a common cause of malaria in Latin America, Asia, and Oceania, but not...
February 2013
Activation of caspase-activated deoxyribonuclease and neuroprotective effect of caspase-3 inhibitor after focal cerebral ischemia-reperfusion injury
Caspase-3 is a key enzyme to execute apoptosis and may be cause internucleosomal DNA fragmentation in ischemic neurons. However, whether caspase-3 inhibitor can directly inhibit caspase-3–dependent deoxyribonuclease activity and prevent neuronal apoptosis following cerebral ischemic is unknown. In this study, we detected the caspase-3 and CAD protein, as well as the frequencies of neuronal apoptosis in both model...
February 2013
Antitumor effects and mechanisms of total saponin and total flavonoid extracts from Patrinia villosa (Thunb.) Juss
Patrinia villosa (Thunb.) Juss is a Chinese edible herbal widely used in China for treatment of carbuncles, acute appendicitis, hepatitis and stasis for hundreds of years. In this study, the antitumor effects and the possible mechanisms of total saponin extract from P. villosa (SPV) and total flavonoid extract from P. villosa (FPV) were investigated in four cancer cell lines including mouse...
February 2013
Intervention study on Chinese medicine Tongxinluo for cardiomyopathy in diabetic rats
The aim of this study was to observe the effect of early application of the Chinese Medicine Tongxinluo on cardiomyopathy in diabetic rats. 36 rats were randomly divided into normal control group, diabetic group and Tongxinluo (TXL) group. Streptozotocin was used for preparation of diabetic model of Sprague Dawley (SD) rats. Tongxinluo powder (1.43 g of crude drug/g dry powder) was dissolved in water and used for gavage...
February 2013
Proximate and nutrient analysis of selected medicinal plants of Tank and South Waziristan area of Pakistan
Inhabitants of Tank and South Waziristan area of Pakistan are facing acute shortage of medicines and food. The purpose of this study was to evaluate the medicinal plants of the area for their nutrient and medicinal values and to recommend their preservation/propagation for medicinal and/or food purposes. The plants investigated were Alhagi maurorum Medik,Datura alba Ness, Chenopodium...
February 2013
Descriptive study of contemporary status of the traditional knowledge on medicinal plants in Bulgaria
In the contemporary reality of globalization and urbanization in Bulgaria, traditional empiric ethnobotanical knowledge is disappearing. The aim of our study was to check the attitude of a random sample of people to the herbs and the traditional way of healing: 1) to find out which herbs are the most popular in Bulgaria; 2) what is their most popular application; 3) to study the distribution of negative or positive...
February 2013
The effect of genistein for preventing granulose cell injury induced by cisplatin
Genistein (GEN), the primary isoflavone in legumes, has a well known weak estrogenic effect by binding to estrogen receptors, and widely used for the treatment of ovary disease induced by chemotherapeutics, however, the details of the exact mechanisms was unclear so far, thus, the aim of our study was to find the effect on granulosa cells of ovary induced by cisplatin (CDDP) after using GEN treatment by...
February 2013
Lentivirus-mediated shRNA targeting decoy receptor 3 (DcR3) inhibits proliferation and augments apoptosis in pancreatic cancer Capan-1 cells
Pancreatic cancer is one of the most dismal malignancies with the actual 5-year survival ofonly 10 to 20%. Decoy receptor 3 (DcR3) is highly expressed in various cancer cells and plays a significant role in immune suppression and tumor progression. However, how DcR3 expression is modulated in pancreatic cancer cells is enigmatic. The aim of this study was to characterize the expression of DcR3 in pancreatic carcinoma...
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