February 2018

Development and validation of high sensitive UHPLC-ESI-MS assay for simultaneous determination of dextromethorphan, dextrorphan, and midazolam in human plasma

A more sensitive and accurate high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS) method has been developed and validated simultaneously for analysis of three analytes. The method is sensitive, enough for the study of analyte pharmacokinetics and metabolic pathways of drugs. The current method includes a simple reversed-phase Liquid chromatography–mass spectrometry...

Author(s): Naser L. Rezk, Saber M. Eweda, , Loay Kasahkary, Omar A. Rezk and Muzaffar Iqbal