November 2013
A novel approach and in-vitro evaluation of bioactive components for the development of nutraceuticals
The nutritional ability of various bioactive components from Solanum melongena pulp (SMP) and Musa paradisiaca pseudo stem pulp (MSP) samples were investigated. The objective of the present investigation was the evaluation and determination of the nutraceutical properties of pulp extracts obtained from these plants. The antimicrobial activity was evaluated by the agar well diffusion method. The total phenolic contents...
November 2013
Determining potential drug-drug interactions between lopinavir/ritonavir and other antiretrovirals and prescribed daily doses in a section of the private health care sector in South Africa
Lopinavir/ritonavir forms part of the antiretroviral therapy for the treatment of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). The aim of this non-experimental, quantitative drug-utilization study was to determine and identify potential drug-drug interactions between lopinavir/ritonavir and other antiretrovirals in general practitioners and specialists prescriptions with inappropriate...
November 2013
Cytolytic and antinociceptive activities of starfish Protoreaster linckii (Blainvilli, 1893)
Echinoderms are exclusively marine animals. Starfish extracts have drawn attention, because of their wide spectrum of biological effects associated with antifungal, cytotoxic, hemolytic and immunomodulatory activities. The study was carried out to investigate the hemolytic and antinociceptive effect of the methanolic extract of Protoreaster linckii (MEPL) using male albino mice models of chemicals and thermal...
November 2013
Ameliorative potential of rutin on streptozotocin-induced neuropathic pain in rat
The aim of the present study is to investigate the effect of rutin, a potent antioxidant and anti-inflammatory compound on experimentally-induced diabetic neuropathy (DN) in male Wistar rats. In diabetic and normal rats, the pain-related behavior tests were performed before and after rutin (50 and 100 mg/kg/day for 6 weeks) treatments. In serum, fasting glucose, insulin, tumor necrosis factor-α (TNF-α),...
November 2013
Antipsychotic drug prescribing to patients with dementia in a South African patient population
The primary aim of this study was to determine the prescribing pattern of antipsychotic drugs to patients with dementia in a South African patient population. A retrospective, cross-sectional drug utilisation study was conducted on 2010 prescription data of a national community pharmacy group. A total of 1231 patients were prescribed medication for dementia. The average age of patients was 75.10...
November 2013
Inhibitory effects of Neem (Azadirachta indica Linn.) and Bitter Kola (Garcinia kola Heckel) leaves on selected pathogenic bacteria
Concoctions of Azadirachta indica Linn (Neem) and Garcinia kola Heckel (Bitter kola) are commonly used for medicinal purposes in most Nigerian rural communities, because they are believed to possess some healing properties. The antibacterial activity of both neem and bitter kola was evaluated by agar well diffusion method against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and...
November 2013
Antioxidant and anticholinesterase activities of aqueous extract of Uraria picta (Jacq.) DC
Numerous plants have been used in treating/managing Alzheimer’s disease in folklore. Inhibition of cholinesterase enzymes is an alternative way used in treating/managing Alzheimer’s disease. This study therefore sought to investigate the interaction of aqueous extract of Uraria picta with key enzymes (acetylcholinesterase and butyrylcholinesterase) linked with Alzheimer’s disease in vitro. Inhibition...
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