African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: 8 October, 2013; 7(37)

October 2013

Effect of Blepharis maderaspatensis L. Roth. extracts on serum lipids in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rats

The present study evaluates anti-hyperlipidaemic and anti-atherogenic activities in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rat models. Chloroform, ethyl acetate and ethanol extracts of whole plant of Blepharis maderaspatensis were evaluated for their anti-hyperlipidaemic and anti-atherogenic activities using Triton WR-1339 induced hyperlipidaemic rats (acute study) and high cholesterol diet...

Author(s): Aiyalu Rajasekaran, Vellaichamy Sivakumar and Sabarimuthu Darlinquine

October 2013

Ginsenoside retinoblastoma 1 (Rb1) suppresses NO production and inducible nitric oxide synthase (iNOS) expression by inhibiting nuclear factor κB (NF-κB) activation in SW1353 chondrosarcoma cells

Ginseng (Panax ginseng C.A. Mey) is commonly used to treat osteoarthritis (OA) in Chinese traditional medicine (TCM). In this study, we investigated whether ginsenoside retinoblastoma 1 (Rb1), an active component of ginseng, could regulate NO production in chondrocytes and its potential mechanisms of action. SW1353 cells were stimulated with IL-1β in the presence of different concentrations of ginsenoside Rb1. NO...

Author(s): Ping Jia, Gang Chen, Rong-Heng Li, Xiao-Feng Rong, Guo-Qing Zhou and Yu Zhong

October 2013

Preoperative evaluation of hepatic reserve function by phenacetin metabolism test for the prevention of postoperative liver dysfunction

The aim of this study was to investigate the utility of the phenacetin metabolism test in evaluating hepatic reserve function prior to hepatectomy for the prevention of postoperative liver dysfunction. Fifty-six patients with hepatocellular carcinoma had undergone hepatectomy. Patients were classified into group I (normal group, n = 37) and group II (with peak total bilirubin >53.8 μmol/L for 7 days after...

Author(s): Qing-hua Zhu, Liang Ming, Long-shuan Zhao, Ping He and Mei-fen Wang

October 2013

Honokiol augments the anti-cancer effects of oxaliplatin on colon cancer cell: Apoptosis and analysis of the molecular mechanisms

The drug oxaliplatin is important in the chemotherapy of colorectal carcinoma, but its toxicity, especially dose-related neurosensory toxicity, is not well tolerated. We investigated if honokiol could augment the anti-tumor effect of oxaliplatin in colon cancer HT-29 cells in vitro and determined if honokiol could be used with oxaliplatin to decrease its dose. Cell proliferation, apoptosis, and prostaglandin E2 (PGE2)...

Author(s): Hanju Hua, Wenbin Chen, Ling Shen, Qinsong Sheng and Lisong Teng

October 2013

Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenofos

The use of pesticides is widespread in agricultural activities. These pesticides may contaminate the irrigation and drainage systems during agricultural activities and pests’ control and then negatively affect the biotic and abiotic component of the polluted water courses. The present study aimed to evaluate the effect of the pesticides diazinon and profenofos on some biological activities of Biomphalaria...

Author(s): Fayez A. Bakry, Karem El-Hommossany, M. S. Abd El-Atti and Somaya M. Ismail

October 2013

Analysis on 115 cases of adverse reactions caused by azithromycin

This study talks about the usage and adverse reactions of azithromycin, and provide references for clinically safe, rational and effective drug use and also to make statistics and analysis on the cases of adverse reactions caused by azithromycin in our hospital in recent 5 years. The main adverse reactions of azithromycin are allergic reaction, gastrointestinal damage, neurotoxicity, etc. Doctors and patients should pay...

Author(s): Jianzhong Jiang#, Yanping Zhao#, Jiannong Jiang, Zhenhuan Jiang, Ruhua Chen, Keyun Shi, Xinnan Gu and Zhijun Ge