October 2013
Effect of Blepharis maderaspatensis L. Roth. extracts on serum lipids in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rats
The present study evaluates anti-hyperlipidaemic and anti-atherogenic activities in Triton WR-1339 and high cholesterol diet induced hyperlipidemia in rat models. Chloroform, ethyl acetate and ethanol extracts of whole plant of Blepharis maderaspatensis were evaluated for their anti-hyperlipidaemic and anti-atherogenic activities using Triton WR-1339 induced hyperlipidaemic rats (acute study) and high cholesterol diet...
October 2013
Ginsenoside retinoblastoma 1 (Rb1) suppresses NO production and inducible nitric oxide synthase (iNOS) expression by inhibiting nuclear factor κB (NF-κB) activation in SW1353 chondrosarcoma cells
Ginseng (Panax ginseng C.A. Mey) is commonly used to treat osteoarthritis (OA) in Chinese traditional medicine (TCM). In this study, we investigated whether ginsenoside retinoblastoma 1 (Rb1), an active component of ginseng, could regulate NO production in chondrocytes and its potential mechanisms of action. SW1353 cells were stimulated with IL-1β in the presence of different concentrations of ginsenoside Rb1. NO...
October 2013
Preoperative evaluation of hepatic reserve function by phenacetin metabolism test for the prevention of postoperative liver dysfunction
The aim of this study was to investigate the utility of the phenacetin metabolism test in evaluating hepatic reserve function prior to hepatectomy for the prevention of postoperative liver dysfunction. Fifty-six patients with hepatocellular carcinoma had undergone hepatectomy. Patients were classified into group I (normal group, n = 37) and group II (with peak total bilirubin >53.8 μmol/L for 7 days after...
October 2013
Honokiol augments the anti-cancer effects of oxaliplatin on colon cancer cell: Apoptosis and analysis of the molecular mechanisms
The drug oxaliplatin is important in the chemotherapy of colorectal carcinoma, but its toxicity, especially dose-related neurosensory toxicity, is not well tolerated. We investigated if honokiol could augment the anti-tumor effect of oxaliplatin in colon cancer HT-29 cells in vitro and determined if honokiol could be used with oxaliplatin to decrease its dose. Cell proliferation, apoptosis, and prostaglandin E2 (PGE2)...
October 2013
Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides diazinon and profenofos
The use of pesticides is widespread in agricultural activities. These pesticides may contaminate the irrigation and drainage systems during agricultural activities and pests’ control and then negatively affect the biotic and abiotic component of the polluted water courses. The present study aimed to evaluate the effect of the pesticides diazinon and profenofos on some biological activities of Biomphalaria...
October 2013
Analysis on 115 cases of adverse reactions caused by azithromycin
This study talks about the usage and adverse reactions of azithromycin, and provide references for clinically safe, rational and effective drug use and also to make statistics and analysis on the cases of adverse reactions caused by azithromycin in our hospital in recent 5 years. The main adverse reactions of azithromycin are allergic reaction, gastrointestinal damage, neurotoxicity, etc. Doctors and patients should pay...
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