African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: April 2009; 3(4)

April 2009

Ultra structural study of gentamicin and ofloxacin effect on testis tissue in rats: Light and transmission electron microscopy

The aim of this study was to investigate the comparative effects of aminoglycosides and fluoroquinolones on testis tissue in rats. Thirty male Wister rats were randomly divided into control (n=10) and experimental (n=20) groups.The experimental groups subdivided into two groups of ten. Each received 5 mg/kg (IP) Gentamicin and 72 mg/kg (IP) Ofloxacin daily for 14 days, respectively; however, the control group just...

Author(s): Arash Khaki, Marefat Ghaffari Novin, AmirAfshin Khaki, Fatemeh Fathiazad, Morteza Khaberi,  Jafar Hossinchi, and Reza Sehizadeh

  • Article Number: 8DA89C933631

April 2009

Clinical evaluation of 99mTc-2IT-INH in normal subjects and patients with tubercular lesions

99mTc-INH of high labeling efficiency and stability has been developed using indirect method. In vitro studies and animal experiments indicated its advantages as a specific tuberculosis imaging agent. The objective of this study was to establish the efficacy of 99mTc-INH in humans with sensitive as well as resistant tuberculosis by conducting a phase I clinical trial. The biodistribution studies were done...

Author(s): Namrata Singh, and Aseem Bhatnagar

  • Article Number: 76F107A33659

April 2009

Pre-hospital and prescription use of antibacterial drugs at a secondary health centre in Ibadan, Nigeria

The overall goal of this study is to reduce morbidity and mortality ascribable to bacterial infections by encouraging rational use of antibiotics. Antibiotics use prior to and prescriptions of antibiotics by the attending physicians were evaluated in a group of patients attending a secondary health facility. A quasi-exit interview was conducted using a structured questionnaire. The major...

Author(s): F. A. Fehintola

  • Article Number: EC1D64633669

April 2009

Formulation and evaluation of novel mucoadhesive ketorolac tromethamine liquid suppository

Ketorolac tromethamine (KT) loaded mucoadhesive liquid suppository was prepared as a site-specific mucoadhesive rectal dosage form. Poloxamer mixture formed of 21% P407 and 9% P188 were used as liquid suppository base. In-vitrorelease rate of KT from liquid suppository was studied and compared to that from conventional suppository. The safety of the prepared suppository on GIT was conducted, hepatotoxicity of KT...

Author(s): Esmail Mohamed Ramadan, Thanaa Mohamed Borg, and Maha Osama Elkayal

  • Article Number: CB7917633690

April 2009

Production of phenolic compounds from Spirulina maxima microalgae and its protective effects in vitro toward hepatotoxicity model

This study illustrates the process of enhancing phenolics synthesis in Spirulinamaxima grown in Zarrouk’s medium supplemented with sodium nitrate (NaNO3) and or phenylalanine (L-PA), attaining highest production obtained in medium containing  3.77 g.L-1 NaNO3 and 100 mgL-1 L-PA. HPLC profile showed the presence of phenolic acids and flavonoids predominantly with gallate, chlorogenate,...

Author(s): Hanaa H. Abd El-Baky, Farouk K. El Baz and Gamal S. El-Baroty

  • Article Number: 1A7EE1433704

April 2009

Antisickling properties of the fermented mixture of Carica papaya Linn and Sorghum bicolor (L.) Moench

The antisickling properties of fermented mixture of dried unripe fruit pulp of Carica papaya and dried Sorghum bicolor leaves, mixed in equal proportions in distilled water, was carried out using sodium metabisulphite sickled red blood cells and the result presented. Equal weight of dried C. papaya fruit pulp and S. bicolor leaves were fermented together in distilled water at room...

Author(s): Cyril-Olutayo Christianah Mojisola, Elujoba Adebolu Anthony and Durosinmi Muheez Alani

  • Article Number: E20033033736

April 2009

Ethnobotany and phytomedicine of the upper Nyong valley forest in Cameroon

This paper presents the results of an assessment of the ethnobotanical uses of some plants recorded in upper Nyong valley forest implemented by the Cameroon wildlife conservation society project (CWCS). Forestry transects in 6 localities, followed by socio-economic study were conducted in 250 local inhabitants. As results, medicinal information on 140 plants species belonging to 60 families were recorded. Local...

Author(s): T. Jiofack, l. Ayissi, C. Fokunang, N. Guedje and V. Kemeuze

  • Article Number: B40F95F33804

April 2009

The modulatory effect of Cochlospermum tinctorium a rich aqueous root extract on liver damage induced by carbon tetrachloride in rats

The aqueous root extract of Cochlospermum tinctorium (CTR) was investigated for its phytochemical composition; acute oral toxicity and hepatoprotective effect on carbon tetrachloride (CCl4) induced liver damage in rats. Phytochemical screening indicates the presence of alkaloids, tannins, cardiac glycosides, saponins, flavonoids, triterpenes, cyanogenic glycosides and volatile oils while steroids and...

Author(s): E. U. Etuk, B. M. Agaie, M. J. Ladan and I. Garba

  • Article Number: 918A77E33830

April 2009

Potential antioxidant phenolic metabolites from doum palm leaves

The antioxidant activity of the aqueous ethanolic extract of doum leaves, Hyphaene thebaica L. (Palmae) was studied. Data obtained showed that the extract can inhibit reactive oxygen species attack on salicylic acid (IC50 = 1602 µg/ml) in a dose dependant manner using xanthine/hypoxanthine oxidase assay. Four major flavonoidal compounds were identified by LC/SEI as; Quercetin...

Author(s): Omayma A. Eldahshan, Nahla A. Ayoub, Abdel-Nasser B. Singab and Mohamed M. Al-Azizi

  • Article Number: EF5590E33859

April 2009

Pilot study comparing technologies to test for substandard drugs in field settings

Researchers procured a range of antimalarial, antibiotic and antimycobacterial drugs from cities in six countries: Ghana, India, Kenya, Nigeria, Tanzania, and Uganda. Semi-quantitative thin-layer chromatography (TLC) and disintegration tests, Raman spectrometry, and near-infrared (NIR) spectrometry were used to measure the concentration of active ingredients and excipients (spectrometry only) to determine whether the...

Author(s): Roger Bate, , Richard Tren, ,Kimberly Hess, Lorraine Mooney and Karen Porter

  • Article Number: 847C33333887