April 2009
Ultra structural study of gentamicin and ofloxacin effect on testis tissue in rats: Light and transmission electron microscopy
The aim of this study was to investigate the comparative effects of aminoglycosides and fluoroquinolones on testis tissue in rats. Thirty male Wister rats were randomly divided into control (n=10) and experimental (n=20) groups.The experimental groups subdivided into two groups of ten. Each received 5 mg/kg (IP) Gentamicin and 72 mg/kg (IP) Ofloxacin daily for 14 days, respectively; however, the control group just...
April 2009
Clinical evaluation of 99mTc-2IT-INH in normal subjects and patients with tubercular lesions
99mTc-INH of high labeling efficiency and stability has been developed using indirect method. In vitro studies and animal experiments indicated its advantages as a specific tuberculosis imaging agent. The objective of this study was to establish the efficacy of 99mTc-INH in humans with sensitive as well as resistant tuberculosis by conducting a phase I clinical trial. The biodistribution studies were done...
April 2009
Pre-hospital and prescription use of antibacterial drugs at a secondary health centre in Ibadan, Nigeria
The overall goal of this study is to reduce morbidity and mortality ascribable to bacterial infections by encouraging rational use of antibiotics. Antibiotics use prior to and prescriptions of antibiotics by the attending physicians were evaluated in a group of patients attending a secondary health facility. A quasi-exit interview was conducted using a structured questionnaire. The major...
April 2009
Formulation and evaluation of novel mucoadhesive ketorolac tromethamine liquid suppository
Ketorolac tromethamine (KT) loaded mucoadhesive liquid suppository was prepared as a site-specific mucoadhesive rectal dosage form. Poloxamer mixture formed of 21% P407 and 9% P188 were used as liquid suppository base. In-vitrorelease rate of KT from liquid suppository was studied and compared to that from conventional suppository. The safety of the prepared suppository on GIT was conducted, hepatotoxicity of KT...
April 2009
Production of phenolic compounds from Spirulina maxima microalgae and its protective effects in vitro toward hepatotoxicity model
This study illustrates the process of enhancing phenolics synthesis in Spirulinamaxima grown in Zarrouk’s medium supplemented with sodium nitrate (NaNO3) and or phenylalanine (L-PA), attaining highest production obtained in medium containing 3.77 g.L-1 NaNO3 and 100 mgL-1 L-PA. HPLC profile showed the presence of phenolic acids and flavonoids predominantly with gallate, chlorogenate,...
April 2009
Antisickling properties of the fermented mixture of Carica papaya Linn and Sorghum bicolor (L.) Moench
The antisickling properties of fermented mixture of dried unripe fruit pulp of Carica papaya and dried Sorghum bicolor leaves, mixed in equal proportions in distilled water, was carried out using sodium metabisulphite sickled red blood cells and the result presented. Equal weight of dried C. papaya fruit pulp and S. bicolor leaves were fermented together in distilled water at room...
April 2009
Ethnobotany and phytomedicine of the upper Nyong valley forest in Cameroon
This paper presents the results of an assessment of the ethnobotanical uses of some plants recorded in upper Nyong valley forest implemented by the Cameroon wildlife conservation society project (CWCS). Forestry transects in 6 localities, followed by socio-economic study were conducted in 250 local inhabitants. As results, medicinal information on 140 plants species belonging to 60 families were recorded. Local...
April 2009
The modulatory effect of Cochlospermum tinctorium a rich aqueous root extract on liver damage induced by carbon tetrachloride in rats
The aqueous root extract of Cochlospermum tinctorium (CTR) was investigated for its phytochemical composition; acute oral toxicity and hepatoprotective effect on carbon tetrachloride (CCl4) induced liver damage in rats. Phytochemical screening indicates the presence of alkaloids, tannins, cardiac glycosides, saponins, flavonoids, triterpenes, cyanogenic glycosides and volatile oils while steroids and...
April 2009
Potential antioxidant phenolic metabolites from doum palm leaves
The antioxidant activity of the aqueous ethanolic extract of doum leaves, Hyphaene thebaica L. (Palmae) was studied. Data obtained showed that the extract can inhibit reactive oxygen species attack on salicylic acid (IC50 = 1602 µg/ml) in a dose dependant manner using xanthine/hypoxanthine oxidase assay. Four major flavonoidal compounds were identified by LC/SEI as; Quercetin...
April 2009
Pilot study comparing technologies to test for substandard drugs in field settings
Researchers procured a range of antimalarial, antibiotic and antimycobacterial drugs from cities in six countries: Ghana, India, Kenya, Nigeria, Tanzania, and Uganda. Semi-quantitative thin-layer chromatography (TLC) and disintegration tests, Raman spectrometry, and near-infrared (NIR) spectrometry were used to measure the concentration of active ingredients and excipients (spectrometry only) to determine whether the...
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