January 2023

Anti-viral compounds from Jatropha curcas seed extract with anti-HIV-1 and anti-SARS-CoV-2 action

Many studies have dealt with the medicinal properties of Jatropha curcas; however, there are limited studies on the scope of its antiviral potential. This is a fact associated with the current challenges posed by HIV-AIDS and COVID-19, which has reinforced the need to expand the knowledge about its antiviral resource. Based on the search for natural products with anti-HIV-1 and anti-SARS-CoV-2 activities, this work...

Author(s): Elvino José de Sousa Ferrão and Edilson Armando De Germano Janeque

January 2023

Acute toxicity and laxative effect of the aqueous extract of the leaves Crossopteryx febrifuga (Benth) in rats

The leaves of Crossepteryx febrifuga (Euphorbiaceae) are commonly used in the Republic of Congo in traditional medicine as a laxative. The present study aims to justify the traditional use of C. febrifuga in the treatment of constipation. The acute toxicity of the aqueous extract was evaluated at the doses of 2000 and 5000 mg/kg in mice in accordance with the OECD (2001) guideline no. 423. The laxative activity of the...

Author(s): Elion Itou RDG,, Etou Ossibi AW, Boukongo R. P., Mambeke H. M., ,Morabandza C. J. and Abena AA