African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: January 2011; 5(1)

January 2009

Resistin and cardiovascular disorder

Resistin belongs to a family of cysteine-rich secreted polypeptides produced by monocy-tes/macrophages. It is also regarded as a novel adipokine that has been suggested to play a role in the development of insulin resistance and obesity. In humans, inflammatory cells seem to be the major source of resistin. Resistin has been suggested to be an independent risk factor involved in the pathogenesis of numerous...

Author(s): Ramica Sharma, Chetan Kumar, Shaveta Gangwani, Gurfateh Singh Sugga and A. C. Rana

  • Article Number: 485EC2A27951

January 2009

Ethno-zoological studies and medicinal values of Similipal Biosphere Reserve, Orissa, India

This paper documents zootherapeutic practices in Similipal Biosphere Reserve of Mayurbhanj district, Orissa, India. It is primarily based on field surveys carried out in villages, where dwellers provided information on animal species used as medicine, body parts used to prepare the remedies, and the illnesses to which the remedies were prescribed. The dominant tribes involved in using animal parts as medicines in the...

Author(s): N. Mishra, S. D. Rout and T. Panda

  • Article Number: 46D8EDC28014

January 2009

Effect of consumption of Cucurbita pepo seeds on haematological and biochemical parameters

The study investigated the effect of Cucurbita pepo seeds on haematological and biochemical parameters on Wistar albino rats. The rats were maintained on diets composed of different concentrations of pulverized seeds of C. pepo. Blood samples and organs investigations were carried out using standard laboratory tests. The result revealed that C. pepo seeds significantly affected...

Author(s): G. K. A. Adepoju and A. A. Adebanjo

January 2009

Evaluation of hyaluronate anti-ulcer activity against gastric mucosal injury

The present study was performed to evaluate the anti-ulcerogenic activity of hyaluronic acid against ethanol induced gastric mucosal injury in rats. Four groups of adultSprague Dawley rats were orally pre-treated respectively with distilled water (ulcer control groups), omeprazole (reference group), high molecular weight hyaluronic acid and 0.8% hyaluronic acid gel (experimental groups) one hour before oral...

Author(s): Fouad Al-Bayaty, Mahamood Abdulla, Poya Darwish  

January 2009

Formulation and evaluation of immediate release tablets with different types of paracetamol powders prepared by direct compression

Paracetamol (PAR) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “Paracetamol for direct compression” are present on the market. Current research demonstrated the best tablet properties with coated paracetamol (mass of tablets, diameter, height and mechanical strength, friability RSD<2%)....

Author(s): Biljana Govedarica, Rade Injac, Rok Dreuand Stane Srcic

January 2009

Effect of alpha-lipoic acid and time-of-day on interleukin-6 response to exhaustive exercise in humans

Circadian rhythms have an influence on human performance. Interleukin-6 is a cytokine which plays a role in muscle energy homeostasis during physical exercise. This study tested the effect of diurnal variation and alpha-lipoic acid, a natural thiol antioxidant, on skeletal muscle contractile properties, interleukin-6 response and oxidative damage. Male subjects (n=26) performed isokinetic...

Author(s): Zekine Lappalainen

January 2009

Antisickling activities of extracts of leaf, seed and seed pod of Garcinia kola Heckel

Garcinia kola has been hitherto speculated as effective in the management of sickle cell disease (SCD). Investigations into the antisickling activities of both crude methanol extracts and the aqueous fractions of the leaf, seed and seed pod of G. kola were carried out using p-hydroxybenzoic acid and normal saline as positive and negative controls respectively. At the tested concentrations of 10.0, 1.0 and...

Author(s): O. E. Adejumo, M. D. Ayoola, A. L. Kolapo, V. O. Orimoyegun and P. O. Olatunji

January 2009

The effect of levosimendan on BNP and other myocardial injury indicators in chronic atrial fibrillation cases with heart failure

To compare effects of levosimendan on brain natriuretic factor (BNP) and other myocardial injury indicators in heart failure (HF) patients with chronic atrial fibrillation (AF) versus sinus rhythm (SR). This study was prospective, double blinded and included a total of 62 chronic HF patients in NYHA III-IV classes. Left ventricular ejection fraction £35%, and with either SR (n=38) or AF (n=24) received a 12...

Author(s): Ibrahim Halil Kurt, Murat Çayli and Mustafa Kemal Batur

January 2009

Turkish pharmacy technicians’ counseling practices and attitudes regarding emergency contraceptive pills

Supplying emergency contraception pills through community pharmacies without the need for a doctor’s prescription is an important public health role for the pharmacy staff, as a way of reducing unwanted pregnancies and induced abortions. Therefore, we aimed to assess the Turkish pharmacy technicians’ counseling practices and attitudes regarding emergency contraception pills. A survey tool...

Author(s): Sule Apikoglu-Rabus, Mesut Sancar, Betul Okuyan and Fikret V. Izzettin

January 2009

Chemotaxonomic clarification of pharmaceutically important species of Cyperus L.

The evaluation of the crude herbal drug which eventually enters the pharmaceutical market is obviously of considerable importance. This operation involves the identification of the material and determination of its quality, purity and of adulterated nature of the adulterants. The present paper is based on the above objectives which confined to chemotaxonomic authentication of Cyprus rotundus L. (Nagar mootha)...

Author(s): Muhammad Zafar, Mushtaq Ahmad, Mir Ajab Khan, Shazia Sultana, Gul Jan, Farooq Ahmad, Asma Jabeen, Ghulam Mujtaba Shah, Shabnum Shaheen, Amin Shah, Abdul Nazir and Sarfaraz Khan Marwat

January 2009

Effect of various superdisintegrants on the drug release profile and disintegration time of Lamotrigine orally disintegrating tablets

The demand for orally disintegrating tablets of lamotrigine has been growing during the last decade especially for the geriatric and pediatric patients. Lamotrigine is a recognized drug for epilepsy, so development of an ODT of lamotrigine and to evaluate the effect of various superdisintegrants on its disintegration time and release profile was the prime objective of this research work. Tablets were prepared by direct...

Author(s): C. Patil and S. Das

January 2009

Assessment of the medical benefit in the folkloric use of Bryophyllum Pinnatum leaf among the Igbos of Nigeria for the treatment of hypertension

The effects of aqueous leaf extract of Bryophyllum pinnatum on the blood pressure of anaesthetized cats, as well as on the liver and kidney status of the rabbit were investigated in this study. The results revealed that, the extract produced a small fall in the blood pressure of the anaesthetized cat and also reduced the effect of adrenaline-induced elevation of blood pressure. In rabbits, biochemical analysis...

Author(s): S. Ghasi, C. Egwuibe, P. U. Achukwu and J. C. Onyeanusi

January 2009

The effect of acute exercises on blood electrolyte values in handball players

This study aimed at determining the effect of five-day competitions on some blood electrolyte, values of male handball players. 12 male handball players voluntarily participated into the study. After briefing the handball players concerning the test to be conducted, physical measurements including age, body height, body weight, body-mass index (BMI) and body fat percentage (BFP) were taken from the players before and...

Author(s): Hürmüz Koç

January 2009

Chromosomal aberrations induced in bone marrow cells of mice due to the administration of the non-steroidal anti-inflammatory drug, Piroxicam

Cytogenetic changes in male albino mice due to the effect of the non-steroidal anti-inflammatory drug, Piroxicam was investigated after daily intraperitoneal injection with 0.3 mg/kg body weight, for 1, 2, 3 and 4 weeks. The observed structural chromosomal aberrations were in the form of chromatid breakage, centric fusion, centromeric attenuation, ring chromosome and end to end association. At all the treatment periods...

Author(s): Mohamed A. Dkhil, Amany Tohamy and Mohamed S. Gabry