January 2024

Antihyperglycemic and pancreatic ?-Cells protective effects of Cassia siamea in Alloxan-induced diabetic wistar rats

The study aimed to investigate the β-cell protective effects of ethanol extracts of Cassia siamea (Fabaceae) leaves (LECS). Initially, acute toxicity of LECS (2000 mg/kg/day/bw; po) was assessed in rats. In vitro, antioxidant activity was evaluated on HUVEC cultures. Subsequently, acute hypoglycemic and antihyperglycemic properties were examined for three doses of LECS (100, 200, and 400 mg/kg/bw; po) in Wistar...

Author(s): Camille KOFFI, N’goran Mathieu KOUAME, Kouassi Eugène KOFFI, Kanga Sita N’ZOUÉ, N’guessan Alain Roland YAO, Brahima DOUKOURE and Mamadou KAMAGATE