July 2009

Stability indicating high performance liquid chromatographic assay for the pharmacokinetics of cyclooxygenase (COX-2) inhibitor etoricoxib in rats

An accurate, sensitive and simple high-performance liquid chromatography (HPLC) assay with UV detection has been developed and validated for the simultaneous determination of etoricoxib and its internal standard (IS) flurbiprofen in plasma has been developed. After plasma samples clean up by protein precipitation, followed by solvent evaporation and reconstitution with the mobile phase, an aliquot of the resulted...

Author(s): Mahasen A. Radwan, Iman Y. Zaghloul and Nayira A. Abd Elbaky

July 2009

Antidiarrhoeal and antibacterial properties of crude aqueous stem bark extract and fractions of Parkia biglobosa (Jacq.) R. Br. Ex G. Don.

Stem bark of Parkia biglobosa (Jacq.) R. Br. Ex G. Don (Fabaceae) is used in African traditional medicine for management of diarrhoea-related disorders. The anti-diarrhoeal and anti-microbial activities of the aqueous stem bark extract of P. biglobosa  and its fractions designated PF1-PF4   were investigated in mice and against selected diarrhoea-causing micro-organisms. The oral...

Author(s): A. Y. Tijani, S. E. Okhale, T. A. Salawu, H. O.Onigbanjo, L. A Obianodo, J. A Akingbasote, O. A Salawu, J. I. Okogun, F. O. Kunle and M. Emeje

July 2009

Bilirubin lowering potential of Orthosiphon stamineus in temporarily jaundiced adult rats

Bilirubin (BR) lowering potential of Orthosiphon stamineus (OS) aqueous extract was evaluated in temporarily jaundiced adult rats. Treatment of these rats with OS aqueous extract for three days reduced the BR level significantly to the normal value. Whereas smaller dose (50 mg/kg body weight) resulted in the reduction in BR level from 2.53 ± 0.16 to 1.12 ± 0.17 mg/dL, higher...

Author(s): Faizah M. Faizul, Norhaniza Aminudin, Habsah A. Kadir and Saad Tayyab

July 2009

Acute and oral subacute toxicity of methanolic extract of Bauhinia monandra leaf in rats

In this study, the acute and subacute toxicity of Bauhinia monandra methanolic leaf extract were investigated in rats. Acute administration of the extract up to a dose of 8 g/kg body weight to the animals elicited no deaths or treatment related signs of toxicity. Oral subacute administration of the extract (2.0 and 4.0 g/kg body weight) did not show any macroscopic changes in the key organs investigated in the...

Author(s): G. O. Alade, M. A. Akanmu, E. M. Obuotor, S. A. Osasan and O. R. Omobuwajo