June 2009

Bioefficacies of Cassia fistula: An Indian labrum

Cassia fistula Linn, a semi-wild Indian labrum has been used in the treatment of various diseases in different parts of the world since time immemorial. In Indian literature there has been multiple descriptions regarding its usefulness in the treatment of various diseases. Some authors have reported its antibacterial, antioxidant, hepatoprotective and hypoglycemic potentials. Many other authors have...

Author(s): M. Moshahid A. Rizvi, , Irshad M. Gamal El Hassadi, Salaem Ben Younis

June 2009

In vitro antibacterial activities of crude extracts of the leaves of Helichrysum longifolium in combination with selected antibiotics

This study has been done to evaluate the interactions between acetone, chloroform, ethyl acetate and methanol extracts of Helichrysum longifolium in combination with six first-line antibiotics comprising of Penicillin G sodium, Amoxicillin, Chloramphenicol, Oxytetracycline, Erythromycin and Ciprofloxacin using both the time-kill and the chequerboard methods and against a panel of bacterial isolates comprised...

Author(s): O. A. Aiyegoro, A. J. Afolayan and A. I. Okoh

June 2009

Anti-athletic fatigue activity of saponins (Ginsenosides) from American ginseng (Panax quinquefolium L.)

To study the anti-athletic fatigue effects of saponins from American ginseng (SAG), male Kunming mice were randomized into 4 groups equally based on body weight after one week adoption, and they are: C group (control mice given distilled water for 14 days), LS group (mice treated SAG with 50 mg/kg for 14 days), MS group (mice treated SAG with 100 mg/kg for 14 days) and HS group (mice treated SAG with 200 mg/kg for 14...

Author(s): Keji Tang, Ruixin Nie, Longjun Jing, , Quansheng Chen

June 2009

Perceptions of oncologists at two state hospitals in Gauteng regarding the ototoxic effects of cancer chemotherapy: A pilot study

This project sought to obtain information regarding the perceptions of oncologists with regards to the ototoxic effects of cancer chemotherapy. Ten oncologists from 2 public hospitals in Gauteng participated in this project. Data were collected from self-administered questionnaires completed by participants. Using a qualitative and quantitative paradigm, data analysis utilized content analysis and descriptive...

Author(s): Victor de Andrade, Katijah Khoza-Shangase and Fatima Hajat

June 2009

Anticonvulsant activity of Rauvolfia Vomitoria (Afzel)

The anticonvulsant activity of the aqueous leaf extract of Rauvolfia vomitoria(Afzel) was investigated by testing the effects of the extract on strychnine-, picrotoxin and pentylenetetrazole induced seizures in mice. Experiments were carried out on male albino mice and the animals were randomly allotted to the different control and test groups. The extract, at a dose of 200 mg/kg, prolonged the onset of seizures...

Author(s): Amole Olufemi Olatokunboh, Yemitan Omoniyi Kayode and Oshikoya Kazeem Adeola

June 2009

Volatile constituents and antioxidant activity of Aucoumea klaineana Pierre essential oil

The essential oil isolated from the resin of Aucoumea klaineana Pierre (Burseraceae) by hydrodistillation was analyzed by capillary gas chromatography (GC) and combined Gas Chromatography/Mass Spectrometry (GC/MS). The analysis led to the identification of 28 components. This oil contained mainly monoterpenoids (96.06%) in which p-acetyl anisole is the single benzenic compound (0.18%). The predominant constituents in...

Author(s): Jean Koudou, Louis-Clément Obame, Brice S. Kumulungui, Prosper Edou, Gilles Figueredo, Jean –Claude Chalchat and Alfred S. Traore

June 2009

A novel method for the determination of pregabalin in bulk pharmaceutical formulations and human urine samples

A simple isocratic reversed phase HPLC method was developed and validated for the analysis of pregabalin in bulk, pharmaceutical formulations and human urine samples, the separation was accomplished on a C18 5 µm ODS hypersil column (250 mm × 4.6 mm) using a methanol acetonitrile - 0.02 M di - potassium hydrogen orthophosphate (K2HPO4) (pH - 7.00) (3: 1: 16, v/v/v) mobile phase. The compound eluted...

Author(s): Rajinder Singh Gujral, Sk Manirul Haque and Sanjeev Kumar

June 2009

Validating the medicinal potential of Leptadenia hastata

Leptadenia hastata (Pers.) Decne is a wild plant used as vegetable by many African populations and medicine due to its nutritive and therapeutic properties for the treatment of wounds and stomach upset in children. Acetone, methanol and aqueous extracts from its leaves were investigated against five selected bacterial species and two fungal species. Aqueous extract markedly inhibited the growth...

Author(s): A. A. Aliero and S. H. Wara