June 2023

Genetic diversity of pvcsp and pvs25 in Plasmodium vivax isolates in malaria-endemic areas in Asia, Africa, and America: A systematic review

Analysis of genetic diversity is an important tool for evaluating Plasmodium vivax drug resistance, relapse patterns, and vaccine development. P. vivax circumsporozoite protein (pvcsp) is involved in sporozoite binding to liver cells. The three pvcsp patterns, i.e., VK210, VK247, or P. vivax-like types, are indentified in P. vivax isolates, which are characterized by repeated sequences. The VK210 pattern is a major...

Author(s): Bashir Abdirahman Guled, Wanna Chiajaroenkul, and Kesara Na-Bangchang,  

June 2023

Relationship between vancomycin trough concentration and 24-h area under the curve concentration in Tunisian patients

The 24-h area under the curve concentration (AUC24 h) is associated with better clinical and bacteriological response to vancomycin in patients with methicillin-resistant Staphylococcus aureus who achieve the target AUC24 h between 400 and 700 mg×h/L. Recent consensus recommends maintaining trough concentrations between 15 and 20 mg/mL as a convenient target  to reach an AUC/minimum inhibitory concentration...

Author(s): Sarra MAHFOUDHI, Emna GAIES,, CHARFI Rim,, Nadia JEBABLI, Mouna BEN SASSI,, Hanene EL JEBARI, Daghfous Riadh, and Sameh TRABELSI,

June 2023

A review of phylogeny, medicinal values, phytochemistry and toxicity of Sarcophyte piriei Hutch (Balanophoraceae)

In recent years, plants have shown potential as sources of antimicrobial agents due to their immense phytochemical constituents, and there is a need to continuously search and develop potent antimicrobial agents to combat the growing threat of antimicrobial resistance worldwide. The challenges facing the utilization of ethnomedicine are lack of sufficient studies to ascertain their therapeutic use. Sarcophyte is a...

Author(s): Dennis Jack Opwoko, Timothy Wachira and Joseph Mwanzia Nguta  

June 2023

Assessment of pharmacy professionals’ knowledge and practice on the management and dispensing of investigational drugs in clinical trials

In quality approach for the development of clinical research in Africa, the level of knowledge and practices of professionals influences the quality of the trial, the confidence of the sponsors in the performance of sites. We evaluated the management and dispensing of experimental drugs in Burkina Faso. From January to June 2018, we conducted a descriptive cross-sectional study with a sample of pharmacists and state...

Author(s): Grissoum Tarnagda, Moussa Ouedraogo, Bavouma Charles Sombié, Luc Kouka Delma, Eric Nagaonle Somé, Jean Claude Romaric Pingwendé Ouédraogo, Olivier Sombié, Maxime K.  Drabo and Rasmané Semdé