African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007
  • Published Articles: 2184

Table of Content: May 2011; 5(5)

May 2011

Caffeine therapy for apnoea of prematurity: Pharmacological treatment

Apnoea of prematurity is among the most commonly diagnosed conditions in the newborn intensive care unit and may prolong the hospital stay of some infants. Resolution of recurrent apnoea and episodes of bradycardia and the completion of an “apnoea-free” period are generally considered to be preconditions for the discharge ofpremature infants without a home cardiorespiratory monitor....

Author(s): H. Orozco-Gregorio, D. Mota-Rojas, D. Villanueva, H. Bonilla-Jaime, X. Suarez-Bonilla, L. Torres-González, D. Bolaños, R. Hernández González, R. Martínez-Rodríguez and M. E. Trujillo-Ortega    

  • Article Number: 67DE98728415

May 2011

Gastric antisecretory and antiulcer effects of ajowan “Carum copticum” in rats

An aqueous suspension of ajowan “Carum copticum” was evaluated for its possible gastric antisecretory and antiulcer activities in various ulcer models in Wistar albino rats. The suspension at 250 and 500 mg kg/body weight, orally (i.p. in Shay rat model) has significant effect in pyloric ligation induced basal gastric acid secretion, indomethacin and noxious chemicals (80% ethanol, 0.2 M NaOH and 25%...

Author(s): Saleh Alqasoumi    

  • Article Number: 7B88CF028463

May 2011

Formulation and evaluation of solid dispersions of Rofecoxib for improvement of dissolution profile

  Rofecoxib is a non-steroidal anti-inflammatory drug, mainly used for osteoarthritis, rheumatoid arthritis, and dysmenorrhea. The major problem with this drug is its very low solubility in biological fluids, which results in poor bioavailability after oral administration. Therefore, solid dispersions of Rofecoxib with urea, polyethylene glycol (PEG) 6000 and polyvinyl pyrrolidone (PVP)...

Author(s): Vyas Jigar, Vyas Puja and Patel Jayvadan

May 2011

Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells

Eupatilin is a flavonoid compound isolated from the Artemisia plant. Eupitillin possesses antioxidant as well as potent anticancer properties. In this study, for the first time, we examined the anti-proliferative effects of Eupatilin in human melanoma A375 cells and its ability to induce apoptosis and cell cycle arrest. Eupatilin specifically induced morphological changes in A375 cells and was less toxic to...

Author(s): Ali Al Shawi#, Azhar Rasul#, Muhammad Khan, Furhan Iqbal and Ma Tonghui  

May 2011

Rifabutin loaded floating gellan gum beads: In vitro and in vivo evaluation

Rifabutin loaded floating gellan gum beads were prepared by ionotropic gelation in acidic medium. Buoyancy to the beads was attributed to the use of gas-generating agent, which produced an extremely porous internal structure lighter than gastric juice. Beads exhibited excellent buoyancy and remained buoyant up to 18 h. Drug incorporation efficiency of the beads was found to be dependent on the concentration of...

Author(s): Anurag Verma and Jayant K. Pandit    

May 2011

Assessment of antibiotic prescribing behavior of consultants of different localities of Pakistan

The objective of study was to evaluate the pattern and practice of consultants especially antimicrobials in the allopathic health sector in Pakistan to assess the magnitude of the problem and suggesting corrective measures. A cross-sectional survey in various cities of Pakistan was conducted which was developed in line with WHO and has so far been implemented in 12 developing countries. A total of 4923 prescriptions of...

Author(s): Humayun Riaz, Farnaz Malik, Atif Raza, Abdul Hameed, Safia Ahmed, Pervaiz Akhtar Shah and Shahzad Hussain    

May 2011

Synthesis and antifungal activity of new 1-(2,4-dichloro phenyl)-3-aryl-2-(1H-1,2,4-triazol-1-yl) prop-2-en-1-one derivatives

A series of novel 1-(2,4-dichlorophenyl)-3-aryl-2-(1H-1,2,4-triazol-1-yl) prop-2- en-1-one derivatives were synthesized in good yields by an aldol condensation between 1-(2,4-dichlorophenyl)-2-(1H-1,2, 4-triazol-1-yl) ethanone and an aryl aldehyde. The structures were established through 1H NMR and 13C NMR spectroscopy and elemental analysis. All compounds 4a-l at a concentration of 50 mg/L showed inhibition...

Author(s): Yinwei Ruan, Linhong Jin, Jiang He, Song Yang, Pinaki S. Bhadury, Ming He, Zhenchao Wang and Baoan Song    

May 2011

High phenolics and antioxidants of some tropical vegetables related to antibacterial and anticancer activities

Phytochemicals play an important role in the decrease risk of free radicals associated diseases. In the present study, total phenolic contents, antioxidant, antibacterial and anticancer activities of thirty Thai vegetables have been evaluated. The results showed that phenolic contents of Thai vegetables were highly correlated with total antioxidant activities. Four vegetables in strains of Spondias pinnata...

Author(s): Jureerut Daduang, Sukanda Vichitphan, Sakda Daduang, Pranithi Hongsprabhas and Patcharee Boonsiri    

May 2011

Immune stimulating activity of water-soluble polysaccharide fractions from Dendrobium nobile Lindl.

Four water-soluble polysaccharides (DNP1-1, DNP2-1, DNP3-1 and DNP4-2) were obtained from the aqueous extracts of the stems of Dendrobium nobile Lindl. by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The evaluation of tumor inhibition and immunomodulatory activity suggested that DNP4-2 could...

Author(s): Aoxue Luo and Yijun Fan    

May 2011

Effects of the aqueous fruit extract of Solanum macrocarpum Linn on the hematological parameters of triton-induced hyperlipidemic rats

The dried and pulverized unripe fruit of Salanum macrocarpum (Solanaceae) was soxlet-extracted with distilled water. Studies were then undertaken on the effect of the aqueous extract on haematological parameters and the leukocytic response on triton-induced hyperlipidemic rats. Graded doses (25, 50, 100 and 200 mg/kg weight, bw) of the extract were...

Author(s): O. A. Sodipo, F. I. Abdulrahman, U. K. Sandabe and J. A. Akinniyi      

May 2011

Evaluation of the antimicrobial activity of Acalypha monostachya Cav. (Euphorbiales: Euphorbiaceae)

Acalypha monostachya (Euphorbiaceae) is used by the inhabitants of San Rafael and Zapotitlan Salinas, Puebla, Mexico, to alleviate illnesses of bacterial and fungal origin. We analyzed the antimicrobial activity of A. monostachya and some of its chemical features. The extracts were obtained by percolation. The antibacterial and antifungal activities were examined through the disc-diffusion method. The...

Author(s): M. Canales, T. Hernández, M. A. Rodriguez-Monroy, C. M. Flores, M. Jiménez-Estrada, L. B. Hernández, A. Durán, M. Hernández-Moreno, N. A. Trejo, A. B. Hernández, J. J. Ramírez, J. Orozco, M. G. Eleno and K. E. Martínez    

May 2011

The effect of Satureja khuzestanica essential oil on the lesions induced by Leishmania major in BALB/c mice

Cutaneous leishmaniasis is the most common form of leishmaniasis that is still treated with expensive drugs, which present side effects. Conventional healers usually are cheap and sometimes more effective than chemical drugs. Satureja khuzestanicais an endemic plant in the west of Lorestan Province, Iran. This plant has therapeutic value. This study was carried out for the first time to assess...

Author(s): Farnaz Kheirandish, Bahram Delfan, Somaye Farhadi, Behrouz Ezatpour, Ali Khamesipour, Bahram Kazemi, Farzad Ebrahimzade and Marzieh Rashidipour    

May 2011

Anabolic drugs consumption by adolescent students of physical education degree in Spain, Portugal and Italy: A survey

This paper aims to analyse the use of anabolic drugs among Spanish, Portuguese and Italian students in the Physical Education and Sport Faculties. In order to do it, a survey was conducted in February and March 2011 in six different Faculties in these three countries. The sample was 144 students in their first or second year at the university.The results showed that although 25.2% of them...

Author(s): Antonio J. Monroy Anton, Gema Sáez Rodríguez, Carlos A. Cordente Martínezand  Manuel Sillero Quintana    

May 2011

Ghrelin promote partial the early recovery of rats after subtotal gastrectomy

The aim of this study was to investigate the validity of exogenous ghrelin for early recovery in partial gastrectomied rats and its long-term significance. The subtotal gastrectomy (B-ltype) rats were randomly divided into two groups, and then they were treated with intraperitoneal injection of saline or ghrelin intervention respectively. Body weight and daily food intake were measured before and after the operation....

Author(s): Song Yu, Zhi-Gang Wang, Cheng-Guang Yang, Jun Yan, Wen-Cai Qiu and Qi Zheng